INT138639

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 32
Total Number 32
Disease Relevance 13.85
Pain Relevance 11.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
oocytes 3
muscle 2
hippocampus 2
Merkel cells 2
sinus 2
Hcn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 302 100.00 Very High Very High Very High
potassium channel 28 100.00 Very High Very High Very High
Kinase C 1 100.00 Very High Very High Very High
hCN2 51 99.90 Very High Very High Very High
c fibre 26 99.68 Very High Very High Very High
Hippocampus 18 99.68 Very High Very High Very High
Root ganglion neuron 10 99.04 Very High Very High Very High
Action potential 300 98.40 Very High Very High Very High
action potential duration 21 97.70 Very High Very High Very High
Spontaneous pain 24 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 4 99.92 Very High Very High Very High
Diabetes Mellitus 28 99.68 Very High Very High Very High
Ganglion Cysts 51 99.64 Very High Very High Very High
Heart Rate Under Development 91 99.24 Very High Very High Very High
Aging 309 98.84 Very High Very High Very High
Injury 20 97.40 Very High Very High Very High
Lifespan 9 97.28 Very High Very High Very High
Pain 29 96.96 Very High Very High Very High
Neuropathic Pain 24 94.80 High High
Hypertrophy 60 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the sham NG, HCN1, HCN3, and HCN4 were expressed in the A-fiber neurons; and HCN2, HCN3, and HCN4 were expressed in the C-fiber neurons.
Gene_expression (expressed) of HCN4 in neurons associated with ganglion cysts, c fibre, hcn1 and hcn2
1) Confidence 0.75 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 1.01 Pain Relevance 0.70
In the sham NG, HCN1, HCN3, and HCN4 were expressed in the A-fiber neurons; and HCN2, HCN3, and HCN4 were expressed in the C-fiber neurons.
Gene_expression (expressed) of HCN4 in neurons associated with ganglion cysts, c fibre, hcn1 and hcn2
2) Confidence 0.75 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 0.99 Pain Relevance 0.62
HCN4 channels, a dominant isoform of HCN channels in the heart, were expressed in HEK293 cells.
Gene_expression (expressed) of HCN4 in heart
3) Confidence 0.73 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19498275 Disease Relevance 0.08 Pain Relevance 0.12
Diabetes alters protein expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits in rat nodose ganglion cells.
Gene_expression (expression) of hyperpolarization-activated cyclic nucleotide-gated in ganglion cells associated with ganglion cysts and diabetes mellitus
4) Confidence 0.65 Published 2010 Journal Neuroscience Section Title Doc Link 19815055 Disease Relevance 0.90 Pain Relevance 0.49
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed in the vagal afferent neurons and play an important role in determining cell membrane excitation.
Gene_expression (expressed) of Hyperpolarization-activated cyclic nucleotide-gated in afferent neurons
5) Confidence 0.65 Published 2010 Journal Neuroscience Section Abstract Doc Link 19815055 Disease Relevance 0.67 Pain Relevance 0.26
Brewster et al. and Surges et al. showed a steady decrease in HCN4 expression throughout the maturation process of the rat hippocampus [23,24].
Gene_expression (expression) of HCN4 in hippocampus associated with hippocampus
6) Confidence 0.62 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.62 Pain Relevance 0.05
There is a linear decrease in the expression of HCN4 throughout the reproductive aging process in the female rat.
Gene_expression (expression) of HCN4 associated with aging
7) Confidence 0.62 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.72 Pain Relevance 0.04
In contrast, no sigmaR1-IR was detected in several subtypes of bipolar cells, including rod-dominant ON-type bipolar cells, types 2, 3, 5 and 8 bipolar cells, labeled by protein kinase C (PKC), recoverin and hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4) respectively.
Gene_expression (detected) of HCN4 associated with kinase c and potassium channel
8) Confidence 0.56 Published 2010 Journal Neuroscience Section Abstract Doc Link 20223280 Disease Relevance 0.16 Pain Relevance 0.22
For HCN4, no protein was detected in the rat ovarian tissue by our whole ovarian extract western blot analysis.
Neg (no) Gene_expression (detected) of HCN4
9) Confidence 0.54 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.28
Fig. 6A shows high-magnification images of Masson's trichrome stained sections of the SAN and atrial muscle (different tissue types were identified by characteristic pattern of expression of Nav1.5 and HCN4 in adjacent tissue sections) in a young and old animal – it shows that the SAN cells were smaller than the atrial cells and both cell types were larger in the old animal.
Gene_expression (expression) of HCN4 in muscle
10) Confidence 0.53 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.09 Pain Relevance 0.08
During ageing, as discussed elsewhere [10], there was no significant change in dV/dtmax and APD15, but there was a significant increase (22%) in action potential duration at 75% repolarization in true and latent pacemaker cells.

3.3 Age-dependent increase in pacemaker tissue lacking expression of Nav1.5 and expressing HCN4

Gene_expression (expression) of HCN4 associated with action potential duration and aging
11) Confidence 0.53 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.09 Pain Relevance 0.20
HCN4 was present only in the oocytes, with declining levels during the reproduction lifespan.


Gene_expression (present) of HCN4 in oocytes associated with lifespan
12) Confidence 0.48 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2533335 Disease Relevance 0.10 Pain Relevance 0.22
In addition to the wide distribution of these channels, it has been previously reported that HCN4 expression in the hippocampus is related to developmental age, suggesting that these channels also have aging-related changes [23,24].
Gene_expression (expression) of HCN4 in hippocampus associated with aging and hippocampus
13) Confidence 0.48 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.32 Pain Relevance 0.20
For HCN4 experimental tissue sections, HCN4 protein expression was localized only to the oocytes.
Gene_expression (expression) of HCN4 in oocytes
14) Confidence 0.48 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.35
HCN1-3 are expressed in ovarian structures including oocytes, granulosa and thecal cells, and in luteal cells, while HCN 4 is only expressed in the oocytes.
Gene_expression (expressed) of HCN 4 in luteal cells associated with hcn1
15) Confidence 0.48 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.34 Pain Relevance 0.17
For HCN4 experimental tissue sections, HCN4 protein expression was localized only to the oocytes.
Gene_expression (expression) of HCN4 in oocytes
16) Confidence 0.48 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.35
HCN channels 1–3 are expressed in oocytes, granulosa cells of primary, preantral, and antral follicles, the thecal cells, and in luteal cells, while HCN4 is only expressed in oocytes.
Gene_expression (expressed) of HCN4 in follicles
17) Confidence 0.48 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0 Pain Relevance 0.09
Another possibility is that it is the result of a decline in the funny current, If, because blockade of If slows pacemaking and familial sick sinus syndrome has also been linked to mutations in HCN4 (main ion channel responsible for If) [2]; If and HCN4 are present in the SAN [2].
Gene_expression (present) of HCN4 in sinus associated with heart rate under development
18) Confidence 0.46 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.18 Pain Relevance 0.06
Why is the leading pacemaker site always located in the main tail of Nav1.5-negative/HCN4-positive tissue next to the crista terminalis rather than the large head of Nav1.5-negative/HCN4-positive tissue in the ventral wall of the superior vena cava?
Neg (negative) Gene_expression (negative) of HCN4 in ventral
19) Confidence 0.46 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0 Pain Relevance 0
Another possibility is that it is the result of a decline in the funny current, If, because blockade of If slows pacemaking and familial sick sinus syndrome has also been linked to mutations in HCN4 (main ion channel responsible for If) [2]; If and HCN4 are present in the SAN [2].
Gene_expression (present) of HCN4 in sinus associated with heart rate under development
20) Confidence 0.46 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.18 Pain Relevance 0.06

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