INT138652

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 7.30
Pain Relevance 2.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
placenta 5
body 1
Mthfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 22 99.90 Very High Very High Very High
cva 14 99.20 Very High Very High Very High
Migraine 8 96.76 Very High Very High Very High
Inflammation 10 91.68 High High
Piles 6 17.36 Low Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Placenta Previa 30 99.90 Very High Very High Very High
Inflammatory Bowel Disease 30 99.36 Very High Very High Very High
Cv General 3 Under Development 14 99.20 Very High Very High Very High
Genetic Predisposition To Disease 1 98.12 Very High Very High Very High
Stomach Cancer 3 98.08 Very High Very High Very High
Disease 28 97.16 Very High Very High Very High
Thrombosis 20 97.04 Very High Very High Very High
Headache 5 96.76 Very High Very High Very High
Migraine Without Aura 1 96.44 Very High Very High Very High
Increased Venous Pressure Under Development 4 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methylenetetrahydrofolate reductase (MTHFR) deficiency is an autosomal recessive disorder with a spectrum of manifestations including neurological symptoms, premature arteriosclerosis, and venous and arterial thrombosis.
Negative_regulation (deficiency) of Methylenetetrahydrofolate reductase associated with increased venous pressure under development and thrombosis
1) Confidence 0.54 Published 2007 Journal J Anesth Section Abstract Doc Link 18008117 Disease Relevance 0.19 Pain Relevance 0.14
Methylenetetrahydrofolate reductase (MTHFR) deficiency is an autosomal recessive disorder with a spectrum of manifestations including neurological symptoms, premature arteriosclerosis, and venous and arterial thrombosis.
Negative_regulation (deficiency) of MTHFR associated with increased venous pressure under development and thrombosis
2) Confidence 0.54 Published 2007 Journal J Anesth Section Abstract Doc Link 18008117 Disease Relevance 0.19 Pain Relevance 0.14
Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.
Negative_regulation (reduction) of MTHFR associated with migraine and genetic predisposition to disease
3) Confidence 0.53 Published 2008 Journal Dis. Markers Section Abstract Doc Link 18957721 Disease Relevance 0.75 Pain Relevance 0.65
Based on observations that inadequate cobalamin intake and reduced MTHFR activity might be significant risk factors for gastric cancer, and the increased risk of gastric cancer shown in patients affected by atrophic gastritis, we speculate that concomitant atrophic gastritis and impaired MTHFR function could have a role in the development of gastric cancer.
Negative_regulation (reduced) of MTHFR associated with atrophic gastritis and stomach cancer
4) Confidence 0.44 Published 2009 Journal Biochem. Genet. Section Abstract Doc Link 19521764 Disease Relevance 0.73 Pain Relevance 0.16
We present a patient undergoing urgent surgery with a preoperative diagnosis of homozygous MTHFR deficiency.
Negative_regulation (deficiency) of MTHFR
5) Confidence 0.39 Published 2007 Journal J Anesth Section Abstract Doc Link 18008117 Disease Relevance 0.17 Pain Relevance 0.17
To our knowledge, there is no reported case of a parturient with MTHFR deficiency complicated with a cerebrovascular accident and associated with placenta previa presenting for a cesarean section.
Negative_regulation (deficiency) of MTHFR in placenta associated with placenta previa and cva
6) Confidence 0.39 Published 2006 Journal J Clin Anesth Section Abstract Doc Link 16980165 Disease Relevance 0.65 Pain Relevance 0.25
Anesthetic considerations are discussed in patients presenting with placenta previa associated with MTHFR deficiency.
Negative_regulation (deficiency) of MTHFR in placenta associated with placenta previa
7) Confidence 0.39 Published 2006 Journal J Clin Anesth Section Abstract Doc Link 16980165 Disease Relevance 0.70 Pain Relevance 0.23
General anesthesia and methylenetetrahydrofolate reductase deficiency.
Negative_regulation (deficiency) of methylenetetrahydrofolate reductase associated with anesthesia
8) Confidence 0.39 Published 2007 Journal J Anesth Section Title Doc Link 18008117 Disease Relevance 0.19 Pain Relevance 0.18
Methylenetetrahydrofolate reductase deficiency increases homocysteine levels in the body and, therefore, predisposes to thrombosis.
Negative_regulation (deficiency) of Methylenetetrahydrofolate reductase in body associated with thrombosis
9) Confidence 0.39 Published 2006 Journal J Clin Anesth Section Abstract Doc Link 16980165 Disease Relevance 0.52 Pain Relevance 0.20
Anesthesia for cesarean section in a patient with placenta previa and methylenetetrahydrofolate reductase deficiency.
Negative_regulation (deficiency) of methylenetetrahydrofolate reductase in placenta associated with anesthesia and placenta previa
10) Confidence 0.39 Published 2006 Journal J Clin Anesth Section Title Doc Link 16980165 Disease Relevance 0.66 Pain Relevance 0.25
We describe the anesthetic management of a patient with placenta previa presenting for a cesarean section, who had methylenetetrahydrofolate reductase (MTHFR) deficiency.
Negative_regulation (deficiency) of MTHFR in placenta associated with placenta previa
11) Confidence 0.39 Published 2006 Journal J Clin Anesth Section Abstract Doc Link 16980165 Disease Relevance 0.51 Pain Relevance 0.19
We describe the anesthetic management of a patient with placenta previa presenting for a cesarean section, who had methylenetetrahydrofolate reductase (MTHFR) deficiency.
Negative_regulation (deficiency) of methylenetetrahydrofolate reductase in placenta associated with placenta previa
12) Confidence 0.39 Published 2006 Journal J Clin Anesth Section Abstract Doc Link 16980165 Disease Relevance 0.51 Pain Relevance 0.19
In contrast, both 677TT and 1298AC/677CT genotypes are known to produce a decreased catalytic enzyme activity of MTHFR [2].
Negative_regulation (decreased) of MTHFR
13) Confidence 0.27 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 0.43 Pain Relevance 0.03
Mahmud and colleagues were the first to report a higher prevalence of MTHFR 677T allele in IBD patients, compared to controls [10].
Negative_regulation (prevalence) of MTHFR associated with inflammatory bowel disease
14) Confidence 0.27 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2533647 Disease Relevance 1.10 Pain Relevance 0.09

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