INT138660

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.59
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Anatomy Link Frequency
neurons 2
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Stimulus evoked pain 1 98.36 Very High Very High Very High
central sensitization 9 91.64 High High
Hyperalgesia 39 90.32 High High
nMDA receptor 14 84.72 Quite High
antagonist 4 84.16 Quite High
Glutamate receptor 1 83.68 Quite High
Thermal hyperalgesia 7 78.92 Quite High
Spinal cord 22 78.36 Quite High
allodynia 6 77.92 Quite High
Perioperative pain 5 76.56 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 99.84 Very High Very High Very High
Hypersensitivity 1 98.36 Very High Very High Very High
Endotoxemia 6 98.24 Very High Very High Very High
Pain 6 97.68 Very High Very High Very High
Hyperalgesia 46 90.32 High High
Heart Rate Under Development 1 87.20 High High
Pressure Volume 2 Under Development 1 86.68 High High
Neuropathic Pain 9 77.92 Quite High
Post Operative Pain 5 76.56 Quite High
Nociception 6 36.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Protein phosphorylation is important for the up-regulation of NMDAR function.
Positive_regulation (important) of Regulation (regulation) of NMDAR
1) Confidence 0.24 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.66 Pain Relevance 1.20
Confocal microscopy further showed that augmented immunoreactivity of NR1 subunit on IML neurons coincided with the phase of endotoxemia when vasomotor tone was augmented; GluR1 immunoreactivity remained stable throughout experimental endotoxemia.
Positive_regulation (augmented) of Regulation (immunoreactivity) of NR1 subunit in neurons associated with endotoxemia and urological neuroanatomy
2) Confidence 0.17 Published 2006 Journal Shock Section Abstract Doc Link 16980884 Disease Relevance 0.93 Pain Relevance 0.51

General Comments

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