INT138670

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH2) small molecule metabolic process (TPH2) cellular nitrogen compound metabolic process (TPH2)
response to stress (TPH2)
Anatomy Link Frequency
brainstem 4
TPH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 13 99.40 Very High Very High Very High
medulla 4 97.60 Very High Very High Very High
Raphe 1 95.36 Very High Very High Very High
Serotonin 7 93.16 High High
depression 13 89.80 High High
antidepressant 3 88.92 High High
carbamazepine 9 74.16 Quite High
bDMF 16 46.76 Quite Low
Neurotransmitter 2 39.88 Quite Low
Lamotrigine 23 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 5 93.92 High High
Depression 16 89.80 High High
Shock 1 75.56 Quite High
Neurodegenerative Disease 4 69.00 Quite High
Apoptosis 4 29.20 Quite Low
Manic Depressive Disorder 125 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 6 5.00 Very Low Very Low Very Low
Psychosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two-week fluoxetine treatment also significantly reduced expression of tryptophan hydroxylase-2 (TPH2) and 5-HT transporter mRNAs as determined by RT-PCR in the brainstem.
Negative_regulation (reduced) of Gene_expression (expression) of TPH2 in brainstem associated with medulla and fluoxetine
1) Confidence 0.42 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16982082 Disease Relevance 0.23 Pain Relevance 0.71
Two-week fluoxetine treatment also significantly reduced expression of tryptophan hydroxylase-2 (TPH2) and 5-HT transporter mRNAs as determined by RT-PCR in the brainstem.
Negative_regulation (reduced) of Gene_expression (expression) of tryptophan hydroxylase-2 in brainstem associated with medulla and fluoxetine
2) Confidence 0.42 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16982082 Disease Relevance 0.23 Pain Relevance 0.71
In the same study, the authors reported that short-term lithium treatment (8 days) resulted in a 45% decrease in tryptophan hydroxylase 2 (TPH2) expression and a 31% reduction in TPH2 protein levels, completely compensated after long-term treatment (14 days).
Negative_regulation (decrease) of Gene_expression (expression) of hydroxylase 2
3) Confidence 0.01 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.44 Pain Relevance 0.26

General Comments

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