INT138673

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.23
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TPH2) small molecule metabolic process (TPH2) cellular nitrogen compound metabolic process (TPH2)
response to stress (TPH2)
Anatomy Link Frequency
brain 4
brainstem 2
TPH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 12 100.00 Very High Very High Very High
medulla 7 99.52 Very High Very High Very High
Serotonin 13 98.68 Very High Very High Very High
drug abuse 24 98.64 Very High Very High Very High
antidepressant 5 97.20 Very High Very High Very High
depression 23 95.00 High High
amygdala 27 79.28 Quite High
Tetrahydrobiopterin 24 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 18 99.76 Very High Very High Very High
Suicidal Behaviour 45 99.00 Very High Very High Very High
Drug Dependence 24 98.64 Very High Very High Very High
Depression 23 95.00 High High
Anxiety Disorder 13 94.40 High High
Genetic Predisposition To Disease 3 92.72 High High
Sprains And Strains 3 68.32 Quite High
Disease 18 40.96 Quite Low
Diabetes Mellitus 3 33.96 Quite Low
Metabolic Disorder 3 33.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of TPH2 expression reveals an unprecedented mechanism of mutually exclusive editing of the alternatively spliced isoforms TPH2a and TPH2b.
Regulation (regulation) of Gene_expression (expression) of TPH2
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.65 Pain Relevance 0.09
Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem.
Regulation (Effect) of Gene_expression (expression) of tryptophan hydroxylase-2 in brainstem associated with medulla and fluoxetine
2) Confidence 0.61 Published 2006 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 16982082 Disease Relevance 0.26 Pain Relevance 0.59
As brain 5-HT biosynthesis is regulated by TPH2 [6], [26], and TPH2 SNPs increase the risk for psychiatric disorders [27], [28], [29], we decided to further analyze the polymorphic variability of the human TPH2 gene and focused on its coding region.
Regulation (regulated) of Gene_expression (increase) of TPH2 in brain
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.13 Pain Relevance 0.10
As brain 5-HT biosynthesis is regulated by TPH2 [6], [26], and TPH2 SNPs increase the risk for psychiatric disorders [27], [28], [29], we decided to further analyze the polymorphic variability of the human TPH2 gene and focused on its coding region.
Regulation (regulated) of Gene_expression (increase) of TPH2 in brain
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.13 Pain Relevance 0.10
Mol Psychiatry 2004; 9:879-889] may be related to the drug effect on the TPH2 gene expression.
Regulation (effect) of Gene_expression (expression) of TPH2 gene
5) Confidence 0.27 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16982082 Disease Relevance 0.07 Pain Relevance 0.55

General Comments

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