INT138676

Context Info Confidence 0.73 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 4.91 Pain Relevance 0.50

peptidase activity (ADAM17) cell motility (ADAM17) cell adhesion (ADAM17) plasma membrane (ADAM17) cytoplasm (ADAM17)

ADAM17 (Homo sapiens)

Pain Link Frequency Relevance Heat imagery 1 97.96 palliative 1 89.92 Chronic pancreatitis 2 75.44 metalloproteinase 4 75.00 cytokine 8 61.80 Inflammation 11 51.00 Infliximab 108 50.00 corticosteroid 14 5.00 rheumatoid arthritis 4 5.00 methotrexate 3 5.00

Disease Link Frequency Relevance Heat Pancreatic Cancer 18 98.36 Hepatocellular Cancer 8 97.64 Colitis 20 97.36 Inflammatory Bowel Disease 106 96.88 Disease 82 94.40 Adenocarcinoma 12 92.80 Biliary Cancer 7 88.64 Cancer 63 87.80 Toxicity 10 80.16 Pancreatitis 2 75.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The proteolytic activity of ADAM17/TACE, assessed by the release of TNF-alpha, was inhibited by TNF-alpha protease inhibitor.

Localization (release) of ADAM17

1) Confidence 0.73 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.29 Pain Relevance 0.14

The proteolytic activity of ADAM17/TACE, assessed by the release of TNF-alpha, was inhibited by TNF-alpha protease inhibitor.

Localization (release) of TACE

2) Confidence 0.32 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.29 Pain Relevance 0.14

Moreover, the TNF-alfa converting enzyme (TACE), which serves to activate and release TNF from the cell membrane, is specifically increased in colonic biopsies of UC patients as compared to biopsies from patients with Crohn’s disease or healthy individuals (Brynskov et al. 2002).

Localization (release) of TACE associated with inflammatory bowel disease and disease

3) Confidence 0.26 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012439 Disease Relevance 1.66 Pain Relevance 0.08

Transarterial hepatic chemoembolization (TACE) is widely used for the management of regionally advanced hepatocellular carcinoma (HCC).

Localization (chemoembolization) of TACE associated with hepatocellular cancer

4) Confidence 0.22 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2856525 Disease Relevance 0.67 Pain Relevance 0.14

General Comments

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