INT138678

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2006
Negated 2
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 4.90
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAM17) cell motility (ADAM17) cell adhesion (ADAM17)
plasma membrane (ADAM17) cytoplasm (ADAM17)
Anatomy Link Frequency
duct epithelial cells 2
ADAM17 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 4 97.08 Very High Very High Very High
metalloproteinase 8 87.48 High High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 12 99.08 Very High Very High Very High
Adenocarcinoma 24 97.20 Very High Very High Very High
Pancreatitis 4 97.08 Very High Very High Very High
Necrosis 8 93.52 High High
Cancer 16 93.16 High High
Adhesions 4 90.44 High High
Malignant Neoplastic Disease 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ADAM17/TACE mRNA was expressed in 3 of 10 normal pancreatic tissues, 6 of 8 samples from patients with chronic pancreatitis, 10 of 10 PDAC tissues, and 9 of 9 pancreatic cancer cell lines, but it was absent in primary duct epithelial cells.
Neg (absent) Transcription (expressed) of TACE in duct epithelial cells associated with adenocarcinoma, pancreatic cancer and chronic pancreatitis
1) Confidence 0.69 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.26 Pain Relevance 0.18
ADAM17/TACE mRNA was expressed in 3 of 10 normal pancreatic tissues, 6 of 8 samples from patients with chronic pancreatitis, 10 of 10 PDAC tissues, and 9 of 9 pancreatic cancer cell lines, but it was absent in primary duct epithelial cells.
Neg (absent) Transcription (expressed) of ADAM17 in duct epithelial cells associated with adenocarcinoma, pancreatic cancer and chronic pancreatitis
2) Confidence 0.69 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.27 Pain Relevance 0.18
Furthermore, ADAM17/TACE mRNA expression was down-regulated in pancreatic cancer cells arrested in G2-M phase as well as in a time-dependent manner after TNF-alpha and interleukin-6 incubation.
Transcription (expression) of ADAM17 associated with pancreatic cancer
3) Confidence 0.52 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.19 Pain Relevance 0.10
Furthermore, ADAM17/TACE mRNA expression was down-regulated in pancreatic cancer cells arrested in G2-M phase as well as in a time-dependent manner after TNF-alpha and interleukin-6 incubation.
Transcription (expression) of TACE associated with pancreatic cancer
4) Confidence 0.52 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.18 Pain Relevance 0.10

General Comments

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