INT138694

Context Info Confidence 0.38 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.97 Pain Relevance 0.48

cytosol (NINL) cytoskeleton (NINL) microtubule organizing center (NINL) cytoplasm (NINL)

Anatomy Link Frequency trigeminal nerve 1 NINL (Homo sapiens)

Pain Link Frequency Relevance Heat fifth nerve 1 98.60 anesthesia 2 97.26 Perioperative pain 1 92.84 Central nervous system 1 87.04 depression 1 83.36 local anesthetic 1 63.04

Disease Link Frequency Relevance Heat Mydriatic 1 99.82 Hypesthesia 1 99.76 Ophthalmoplegia 1 99.60 Ocular Toxicity (including Many Sub-types) 2 99.14 Post Operative Pain 1 92.84 Blindness 1 85.08 Orbital Fractures 1 84.52 Respiratory Failure 1 84.32 Syndrome 2 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After administration of local anesthesia through the catheter on postoperative day 1, the patient had development of a complete ptosis, total ophthalmoplegia, mydriasis, vision loss from 20/20 to NLP, and hypesthesia of the V1 and V2 trigeminal nerve distribution.

Negative_regulation (loss) of NLP in trigeminal nerve associated with mydriatic, hypesthesia, fifth nerve, anesthesia, ophthalmoplegia and ocular toxicity (including many sub-types)

1) Confidence 0.38 Published 2006 Journal Ophthal Plast Reconstr Surg Section Abstract Doc Link 16985427 Disease Relevance 0.97 Pain Relevance 0.48

General Comments

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