INT138696

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 57
Total Number 59
Disease Relevance 59.57
Pain Relevance 19.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 14
macrophage 5
Kupffer cell 2
blood 2
mesenteric artery 2
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1293 100.00 Very High Very High Very High
chemokine 671 100.00 Very High Very High Very High
cytokine 568 100.00 Very High Very High Very High
metalloproteinase 239 99.88 Very High Very High Very High
Paracetamol 22 99.78 Very High Very High Very High
Neuropathic pain 10 99.68 Very High Very High Very High
Central nervous system 370 99.48 Very High Very High Very High
rheumatoid arthritis 91 99.20 Very High Very High Very High
Chronic pancreatitis 15 99.08 Very High Very High Very High
Peripheral nervous system 7 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1466 100.00 Very High Very High Very High
Cancer 939 100.00 Very High Very High Very High
Glioblastoma 594 100.00 Very High Very High Very High
Obesity 197 100.00 Very High Very High Very High
Necrosis 116 100.00 Very High Very High Very High
Diabetes Mellitus 220 99.98 Very High Very High Very High
Multiple Sclerosis 641 99.96 Very High Very High Very High
Injury 303 99.96 Very High Very High Very High
Targeted Disruption 237 99.96 Very High Very High Very High
Adhesions 108 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, Bartosik-Psujek and Stelmasiak [61] observed an increase in both CCL2 and CCL5 in the CSF of patients with IND, and suggested that the drop of CCL2 during relapses is characteristic only of MS.
Positive_regulation (increase) of CCL2 associated with multiple sclerosis, neurological disease and recurrence
1) Confidence 0.67 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 2.04 Pain Relevance 0.45
MCP-1 is a chemokine which is also upregulated in serum of AD patients and may play a role in early inflammatory events [28].
Positive_regulation (upregulated) of MCP-1 associated with chemokine, inflammation and disease
2) Confidence 0.54 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 1.16 Pain Relevance 0.38
Additionally, MC3R expression is crucial in mediating the anti-inflammatory effects induced by vascular tissue injury, as MC3R KO mice exhibit increased cell emigration and adhesion and increased monocyte chemotactic protein-1(MCP-1) and keratinocyte-derived chemokine mRNA expression in response to mesenteric artery tissue injury [34].
Positive_regulation (increased) of monocyte chemotactic protein-1 in mesenteric artery associated with chemokine, inflammation, injury and adhesions
3) Confidence 0.53 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.41 Pain Relevance 0.66
Additionally, MC3R expression is crucial in mediating the anti-inflammatory effects induced by vascular tissue injury, as MC3R KO mice exhibit increased cell emigration and adhesion and increased monocyte chemotactic protein-1(MCP-1) and keratinocyte-derived chemokine mRNA expression in response to mesenteric artery tissue injury [34].
Positive_regulation (increased) of MCP-1 in mesenteric artery associated with chemokine, inflammation, injury and adhesions
4) Confidence 0.53 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.42 Pain Relevance 0.67
These observations suggest a key role for CCL2 in the recruitment of macrophages into the CNS and thus, in the pathogenesis of EAE [29,30,4].
Positive_regulation (role) of CCL2 in macrophages associated with multiple sclerosis and central nervous system
5) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.71 Pain Relevance 0.29
To correlate previous data on CCL concentrations in the CSF of MS patients, Kivisakk et al [68] measured mRNA for CCL2 / MCP-1 and CCL5 / RANTES in MNCs in the CSF and blood of patients with MS, acute meningitis and normal controls.
Positive_regulation (/) of MCP-1 in blood associated with multiple sclerosis and meningitis
6) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.84 Pain Relevance 0.76
To correlate previous data on CCL concentrations in the CSF of MS patients, Kivisakk et al [68] measured mRNA for CCL2 / MCP-1 and CCL5 / RANTES in MNCs in the CSF and blood of patients with MS, acute meningitis and normal controls.
Positive_regulation (/) of CCL2 in blood associated with multiple sclerosis and meningitis
7) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.84 Pain Relevance 0.76
These data were confirmed for Ccl2 and Cxcl10 at the protein accumulation level, as detected in ischemic retina 24 h after reperfusion by immunohistochemistry (Figure 4B).
Positive_regulation (confirmed) of Ccl2 in retina
8) Confidence 0.48 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013064 Disease Relevance 0.81 Pain Relevance 0.37
We examined the status of CCR2 receptor activation in a demyelination injury model of neuropathic pain and found that MCP1-induced CCR2 receptor activation mainly occurred in the peripheral nervous system, including the injured peripheral nerve and dorsal root ganglia.
Positive_regulation (activation) of MCP1 in peripheral nerve associated with demyelination, peripheral nervous system, injury and neuropathic pain
9) Confidence 0.48 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 1.04 Pain Relevance 0.94
By 16 weeks, the majority of these genes were not differentially expressed in the B6 lung and the cancer category then included upregulated chemotactic genes (CCL2, CXCL2) which reflected the cell movement molecular and cellular function (Table 2).
Positive_regulation (upregulated) of CCL2 in lung associated with cancer
10) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.35 Pain Relevance 0.04
In the A/J GMA-SS-exposed lung, the top network included 22 significantly upregulated focus molecules such as inflammatory chemokines regulating cell (monocyte, natural killer, and neutrophil) movement such as CCL2 and CCL4 and CXCL2 (Figure 6, panel A).
Positive_regulation (upregulated) of CCL2 in monocyte associated with chemokine, inflammation and aids-related complex
11) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC2892448 Disease Relevance 1.10 Pain Relevance 0.13
Subsequent experiments revealed that acute ablation of GRP78 protein by AB5 subtilase cytotoxin caused reinforcement of MCP-1 induction and NF-kappaB activation by TNF-alpha and that transfection with GRP78 significantly suppressed the cytokine-induced activation of NF-kappaB.
Positive_regulation (induction) of MCP-1 associated with cytokine
12) Confidence 0.47 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.33 Pain Relevance 0.18
The relationship between LPS treatment, CCL2 expression and MNC recruitment into the CNS remains partially understood, and seems to involve a complex immune regulatory mechanism rather than just a selective effect mediated by the upregulation of the CCL2 transgene.
Positive_regulation (upregulation) of CCL2 in MNC associated with central nervous system
13) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.48 Pain Relevance 0.29
The I/R procedure incremented (from doubling to nearly trebling) tissue levels of MCP-1 and KC (Fig. 3).
Positive_regulation (incremented) of MCP-1
14) Confidence 0.45 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.10 Pain Relevance 0.14
EAE induction enhanced cerebral production of the chemokines CCL2 and CCL5 in WT mice (Figure 4A, B).
Positive_regulation (enhanced) of CCL2 associated with chemokine and multiple sclerosis
15) Confidence 0.42 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.06 Pain Relevance 0.27
In the PU.1 null wound, CCL2 and CCL7 are also upregulated at 3 hours but to a lesser degree than in the wild-type, and unlike in the wild-type, expression is immediately downregulated, so that by 12 hours post-wounding there is a complete absence of expression (Figure 7Cd,g).
Positive_regulation (upregulated) of CCL2 associated with injury
16) Confidence 0.40 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.75 Pain Relevance 0.21
In particular, the relatively high expression of heme oxygenase 1 after 3 days represents persistent reactive oxygen species production from cell debris, while the high CCL2 and CCL4 expression characterize the inflammatory response associated with strong macrophage activity.
Positive_regulation (high) of CCL2 in macrophage associated with inflammatory response
17) Confidence 0.40 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2997608 Disease Relevance 0.41 Pain Relevance 0.25
was absent from unmanipulated CNS, but upregulated in EAE; unmanipulated CCL2 Tg mice showed a basal level of IFN?
Positive_regulation (unmanipulated) of CCL2 associated with targeted disruption, multiple sclerosis and central nervous system
18) Confidence 0.39 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.61 Pain Relevance 0.32
Conversely, Trevaskis et al. have shown an increase in macrophage infiltration and increases in and CD68 and MCP-1 mRNA expression within the adipose tissue in MC3R KO mice compared to control [33].
Positive_regulation (increases) of MCP-1 in adipose tissue associated with obesity
19) Confidence 0.39 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 0.43 Pain Relevance 0.16
RESULTS: CCL2/CCR2, CXCL10/CXCR3 and CCL5/CCR1, CCR5 expression was significantly increased in the sciatic nerves of sm-EAN mice compared with controls.
Positive_regulation (creased i) of CCL2 in sciatic nerves
20) Confidence 0.38 Published 2010 Journal Neuropathol. Appl. Neurobiol. Section Body Doc Link 20500551 Disease Relevance 0.07 Pain Relevance 0

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