INT138698

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Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 11.71
Pain Relevance 4.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Txn1) transport (Txn1) mitochondrion (Txn1)
extracellular region (Txn1) nucleus (Txn1) enzyme binding (Txn1)
Anatomy Link Frequency
stellate cells 1
acinar cells 1
epithelial cells 1
bowel 1
lung 1
Txn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 24 99.48 Very High Very High Very High
fibrosis 12 99.26 Very High Very High Very High
Inflammation 126 98.72 Very High Very High Very High
Analgesic 6 93.32 High High
cytokine 51 92.32 High High
chemokine 25 91.76 High High
isoflurane 35 90.16 High High
cINOD 4 72.88 Quite High
Inflammatory response 9 71.96 Quite High
ischemia 2 69.60 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 46 99.88 Very High Very High Very High
Pancreatitis 24 99.48 Very High Very High Very High
Adenocarcinoma 3 99.36 Very High Very High Very High
Fibrosis 13 99.26 Very High Very High Very High
Leukemia 7 99.08 Very High Very High Very High
Pulmonary Disease 6 98.88 Very High Very High Very High
Inflammatory Bowel Disease 1 98.72 Very High Very High Very High
Cancer 87 98.68 Very High Very High Very High
Infection 7 98.24 Very High Very High Very High
Stress 152 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of recombinant human Trx-1 (rhTrx-1) or transfection of the Trx-1 gene reduced indomethacin-induced cytotoxicity in rat gastric epithelial RGM-1 cells.
Gene_expression (transfection) of Trx-1
1) Confidence 0.77 Published 2007 Journal Free Radic. Res. Section Abstract Doc Link 17654042 Disease Relevance 0.85 Pain Relevance 0.07
Administration of recombinant human Trx-1 (rhTrx-1) or transfection of the Trx-1 gene reduced indomethacin-induced cytotoxicity in rat gastric epithelial RGM-1 cells.
Gene_expression (transfection) of rhTrx-1
2) Confidence 0.77 Published 2007 Journal Free Radic. Res. Section Abstract Doc Link 17654042 Disease Relevance 0.85 Pain Relevance 0.07
Administration of recombinant human Trx-1 (rhTrx-1) or transfection of the Trx-1 gene reduced indomethacin-induced cytotoxicity in rat gastric epithelial RGM-1 cells.
Gene_expression (transfection) of Trx-1 gene
3) Confidence 0.77 Published 2007 Journal Free Radic. Res. Section Abstract Doc Link 17654042 Disease Relevance 0.85 Pain Relevance 0.07
Furthermore, neurotropin enhanced TRX expression in mouse lungs and ameliorated cigarette smoke-induced lung injury in mice, suggesting that its cytoprotective effects in lung epithelial cells are mediated through the induction of redox-regulating molecules that reduce intracellular oxidative activity.
Gene_expression (expression) of TRX in epithelial cells associated with lung injury
4) Confidence 0.64 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17585112 Disease Relevance 0.68 Pain Relevance 0.06
Because infection by viruses, such as human T-cell leukemia virus type I and Epstein-Barr virus, induces expression of the redox-regulating molecule, thioredoxin (TRX), we hypothesized that neurotropin would also be capable of regulating the redox balance and could be applied for the therapeutics of lung diseases caused by oxidative stress, such as chronic obstructive pulmonary disease.
Gene_expression (expression) of TRX in lung associated with stress, leukemia, pulmonary disease and infection
5) Confidence 0.64 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17585112 Disease Relevance 0.64 Pain Relevance 0.09
Overexpression of TRX-1 also attenuated pancreatic fibrosis and suppressed the activation of pancreatic stellate cells.
Gene_expression (Overexpression) of TRX-1 in stellate cells associated with fibrosis
6) Confidence 0.58 Published 2006 Journal Antioxid. Redox Signal. Section Abstract Doc Link 16987036 Disease Relevance 1.07 Pain Relevance 0.75
Overexpression of redox-active protein thioredoxin-1 prevents development of chronic pancreatitis in mice.
Gene_expression (Overexpression) of thioredoxin-1 associated with chronic pancreatitis
7) Confidence 0.58 Published 2006 Journal Antioxid. Redox Signal. Section Title Doc Link 16987036 Disease Relevance 1.02 Pain Relevance 0.76
Overexpression of TRX-1 also reduced H(2)O(2)-induced MCP-1 production in isolated pancreatic acinar cells.
Gene_expression (Overexpression) of TRX-1 in acinar cells
8) Confidence 0.58 Published 2006 Journal Antioxid. Redox Signal. Section Abstract Doc Link 16987036 Disease Relevance 0.93 Pain Relevance 0.68
This study aimed to clarify the protective role of thioredoxin-1 (TRX-1), a redox-regulating protein with antioxidative activity, in MCP-1 production and pancreatic fibrosis using a CP model in transgenic mice overexpressing TRX-1 (TRX-1-TG mice) and wildtype C57BL/6 mice.
Gene_expression (overexpressing) of TRX-1 associated with targeted disruption, fibrosis and chronic pancreatitis
9) Confidence 0.58 Published 2006 Journal Antioxid. Redox Signal. Section Abstract Doc Link 16987036 Disease Relevance 1.11 Pain Relevance 0.77
Neurotropin enhanced mRNA expression of the redox-regulating molecules, glutathione peroxidase and catalase and, particularly, TRX, in human lung adenocarcinoma A549 cells.
Gene_expression (expression) of TRX in A549 associated with adenocarcinoma
10) Confidence 0.50 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17585112 Disease Relevance 0.77 Pain Relevance 0.08
Transgenic mice overexpressing thioredoxin (TRX-tg) have been used to evaluate the role of this protein in stress resistance and longevity.
Gene_expression (overexpressing) of TRX associated with stress, targeted disruption and aging
11) Confidence 0.20 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 1.20 Pain Relevance 0.08
Serum TRX levels were elevated in patients with inflammatory bowel disease.
Gene_expression (levels) of TRX in bowel associated with inflammation
12) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.64 Pain Relevance 0.68
We first evaluated whether thioredoxin-1 can be detected on the Granta cell surface.
Gene_expression (detected) of thioredoxin-1
13) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780735 Disease Relevance 0 Pain Relevance 0
In tumor cells, the thioredoxin (Trx)/thioredoxin reductase (TrxR) couple produces a reduced form of extracellular Trx, which acts as a growth factor conferring protection from the NK-lysin, tumor necrosis factor-?
Gene_expression (produces) of Trx associated with necrosis and cancer
14) Confidence 0.02 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.54 Pain Relevance 0
OXT-922 suppressed nuclear factor-kappaB activation and downregulated thioredoxin-1 expression.
Gene_expression (expression) of thioredoxin-1
15) Confidence 0.01 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20627873 Disease Relevance 0.56 Pain Relevance 0.08

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