INT138700

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 24.10
Pain Relevance 9.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 8
macrophage 5
platelet 4
retinas 2
grey matter 2
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 63 99.62 Very High Very High Very High
chemokine 411 99.56 Very High Very High Very High
Inflammation 509 99.04 Very High Very High Very High
ischemia 30 98.80 Very High Very High Very High
Multiple sclerosis 255 97.96 Very High Very High Very High
fibrosis 83 97.32 Very High Very High Very High
rheumatoid arthritis 61 97.16 Very High Very High Very High
Central nervous system 230 95.80 Very High Very High Very High
diabetic neuropathy 7 95.64 Very High Very High Very High
metalloproteinase 35 94.52 High High
Disease Link Frequency Relevance Heat
Adhesions 85 100.00 Very High Very High Very High
Atherosclerosis 84 100.00 Very High Very High Very High
Dementia 4 99.48 Very High Very High Very High
Multiple Sclerosis 402 99.12 Very High Very High Very High
Urological Neuroanatomy 4 99.08 Very High Very High Very High
INFLAMMATION 566 99.04 Very High Very High Very High
Brain Hemorrhage 5 98.80 Very High Very High Very High
Meningitis 13 98.68 Very High Very High Very High
Recurrence 65 98.48 Very High Very High Very High
Necrosis 39 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The consistently observed decrease in CCL2 levels in the CSF during or even prior to a relapse generated alternative considerations.
Negative_regulation (decrease) of Gene_expression (levels) of CCL2 associated with recurrence
1) Confidence 0.57 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.71 Pain Relevance 0.30
In addition, both siRNA treatments showed a significant reduction of gene expression of Ccl2, an active biomaker of inflammation, which was up-regulated in bleomycin stimulated mice (Figure 5B).


Negative_regulation (reduction) of Gene_expression (expression) of Ccl2 associated with inflammation
2) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.61 Pain Relevance 0.17
In addition, a significant reduction of the Ccl2 expression in the siRNA-treated lung tissues also suggests an improvement of inflammation supporting the findings in histological staining.
Negative_regulation (reduction) of Gene_expression (expression) of Ccl2 in lung associated with inflammation
3) Confidence 0.55 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.84 Pain Relevance 0.38
Thus, it is possible that the inhibition of CCL2 production observed in B2-/- mice would lead to lesser activation of infiltrated leucocytes and, hence, stabilization of the severity of clinical signs.
Negative_regulation (inhibition) of Gene_expression (production) of CCL2 in leucocytes
4) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.15 Pain Relevance 0.22
While high numbers of MNCs expressing CCL2 and CCL5 were found in some patients, overall no differences were observed between MS and acute meningitis.
Negative_regulation (numbers) of Gene_expression (expressing) of CCL2 associated with multiple sclerosis and meningitis
5) Confidence 0.41 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.74 Pain Relevance 0.71
Jee et al [15] compared the histological features and MCP-1 (CCL2) and CCR2 expression levels in the lesions of Lewis rats during the acute attack of monophasic EAE and during the first two clinical events of CR-EAE.
Negative_regulation (compared) of Gene_expression (expression) of CCL2 associated with multiple sclerosis
6) Confidence 0.41 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.79 Pain Relevance 0.29
Jee et al [15] compared the histological features and MCP-1 (CCL2) and CCR2 expression levels in the lesions of Lewis rats during the acute attack of monophasic EAE and during the first two clinical events of CR-EAE.
Negative_regulation (compared) of Gene_expression (expression) of MCP-1 associated with multiple sclerosis
7) Confidence 0.41 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.79 Pain Relevance 0.29
B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?
Negative_regulation (reduced) of Gene_expression (expression) of Ccl2 in retinas
8) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.98 Pain Relevance 0.35
We found that, in murine podocytes, expression of monocyte chemoattractant protein 1 (MCP-1) in response to TNF-alpha was suppressed by indomethacin but not by ibuprofen.
Neg (not) Negative_regulation (suppressed) of in podocytes Gene_expression (expression) of MCP-1 in monocyte
9) Confidence 0.40 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.31 Pain Relevance 0.18
Overexpression of TRX-1 also reduced H(2)O(2)-induced MCP-1 production in isolated pancreatic acinar cells.
Negative_regulation (reduced) of Gene_expression (production) of MCP-1 in acinar cells
10) Confidence 0.39 Published 2006 Journal Antioxid. Redox Signal. Section Abstract Doc Link 16987036 Disease Relevance 0.81 Pain Relevance 0.58
Serum levels of MCP-1 and pancreatic expression of transforming growth factor-beta, platelet-derived growth factor, and MCP-1 were reduced in TRX-1-TG mice compared with levels in wild-type mice.
Negative_regulation (reduced) of Gene_expression (expression) of MCP-1 in platelet
11) Confidence 0.39 Published 2006 Journal Antioxid. Redox Signal. Section Abstract Doc Link 16987036 Disease Relevance 1.01 Pain Relevance 0.73
Serum levels of MCP-1 and pancreatic expression of transforming growth factor-beta, platelet-derived growth factor, and MCP-1 were reduced in TRX-1-TG mice compared with levels in wild-type mice.
Negative_regulation (reduced) of Gene_expression (levels) of MCP-1 in platelet
12) Confidence 0.39 Published 2006 Journal Antioxid. Redox Signal. Section Abstract Doc Link 16987036 Disease Relevance 1.02 Pain Relevance 0.74
These inhibitory effects were mirrored by a marked inhibition in the mesenteric tissue protein expression of both MCP-1 and KC, as well as of MPO activity; calculated inhibitions of 65, 80, and 90% were obtained for each marker of inflammation, respectively, when compared with WT mice treated with vehicle and subjected to I/R procedure (data not shown; n=6; P<0.05).
Negative_regulation (inhibition) of Gene_expression (expression) of MCP-1 associated with inflammation and urological neuroanatomy
13) Confidence 0.39 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.69 Pain Relevance 0.27
These findings were confirmed in 5-LO-deficient mice receiving SC-236, which also showed reduced hepatic monocyte chemoattractant protein 1 expression.
Negative_regulation (reduced) of Gene_expression (expression) of hepatic monocyte chemoattractant protein 1 in monocyte
14) Confidence 0.39 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17766677 Disease Relevance 0.72 Pain Relevance 0.32
42 were positively correlated, and in addition, MCP-1 and all species of A?
Negative_regulation (positively) of Gene_expression (correlated) of MCP-1
15) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 0.42 Pain Relevance 0.24
42 were positively correlated, and in addition, MCP-1 and all species of A?
Negative_regulation (species) of Gene_expression (correlated) of MCP-1
16) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 0.42 Pain Relevance 0.24
42 were positively correlated, and in addition, MCP-1 and all species of A?
Negative_regulation (were) of Gene_expression (correlated) of MCP-1
17) Confidence 0.33 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2955708 Disease Relevance 0.42 Pain Relevance 0.24
We found that, in murine podocytes, expression of monocyte chemoattractant protein 1 (MCP-1) in response to TNF-alpha was suppressed by indomethacin but not by ibuprofen.
Neg (not) Negative_regulation (suppressed) of in podocytes Gene_expression (expression) of monocyte chemoattractant protein 1 in monocyte
18) Confidence 0.29 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18799549 Disease Relevance 0.31 Pain Relevance 0.18
In RASFs vasoactive intestinal peptide was able to down-regulate the lipopolysaccharide-induced but not the constitutive expression of TLR4, followed by a decrease in production of CCL2 and CXCL8 chemokines [9].
Negative_regulation (decrease) of Gene_expression (production) of CCL2 associated with chemokine
19) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.87 Pain Relevance 0.45
In human umbilical vein endothelial cells (HUVECs), budlein A also reduced the production of TNF-alpha, monocyte chemoattractant protein-1 (MCP-1), IL-8, nitrites and CAM expression elicited by LPS.
Negative_regulation (reduced) of Gene_expression (production) of monocyte chemoattractant protein-1 in umbilical vein
20) Confidence 0.21 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19524419 Disease Relevance 0.61 Pain Relevance 0.39

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