INT138715

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 6.97
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (POLG) cell death (POLG) aging (POLG)
DNA binding (POLG) nucleotidyltransferase activity (POLG) DNA metabolic process (POLG)
Anatomy Link Frequency
eggs 1
POLG (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 1 94.88 High High
imagery 54 69.08 Quite High
peripheral neuropathy 5 64.24 Quite High
depression 8 62.56 Quite High
fibrosis 6 37.44 Quite Low
Pain 15 20.96 Low Low
headache 8 18.80 Low Low
Inflammation 15 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
Neuropathic pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 96 100.00 Very High Very High Very High
Chronic Progressive External Ophthalmoplegia 40 100.00 Very High Very High Very High
Helminth Infection 552 99.74 Very High Very High Very High
Targeted Disruption 9 99.58 Very High Very High Very High
Stress 16 99.56 Very High Very High Very High
Neurological Disease 1 96.12 Very High Very High Very High
Headache 9 94.88 High High
Epilepsy 22 94.48 High High
Parkinson's Disease 56 93.96 High High
Syndrome 34 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detection of the POLG1 c.2447G>A (p.R722H) mutation
Gene_expression (c.2447G>A) of POLG1
1) Confidence 0.66 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2873323 Disease Relevance 0.08 Pain Relevance 0.03
Analysis of the POLG1, POLG2, ANT1 and Twinkle genes
Gene_expression (genes) of POLG1
2) Confidence 0.66 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2873323 Disease Relevance 0.36 Pain Relevance 0.03
Detection of the POLG1 c.2447G>A (p.R722H) mutation
Gene_expression (Detection) of POLG1
3) Confidence 0.66 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2873323 Disease Relevance 0.08 Pain Relevance 0.03
In addition, environmental temperature both higher (25°C) and lower (15°C) than 20°C present quite a metabolic stress on worms, as we have detected that all different strains, including N2, glp-4(bn2), polg-1(ok1548) and polg-1(ok1548) glp-4(bn2) mutants, had highly increased mtDNA content when grown at those temperatures (Table 2).
Gene_expression (detected) of polg-1 associated with stress, helminth infection and sprains and strains
4) Confidence 0.64 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.74 Pain Relevance 0
polg-1(ok1548)/mIn[dpy10(e128)mIs14]II
Gene_expression (mIs14) of polg-1
5) Confidence 0.64 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.42 Pain Relevance 0
glp-4(bn2)I, polg-1(ok1548)/mIn[dpy10(e128)mIs14]II
Gene_expression (bn2) of polg-1
6) Confidence 0.64 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.40 Pain Relevance 0
Clinically, POLG mutations can present from early neonatal life to late middle age, with a spectrum of phenotypes that includes common neurological disorders such as migraine, epilepsy and Parkinsonism.
Gene_expression (present) of POLG associated with parkinson's disease, epilepsy, neurological disease and migraine
7) Confidence 0.57 Published 2006 Journal Hum. Mol. Genet. Section Abstract Doc Link 16987890 Disease Relevance 0.71 Pain Relevance 0.09
Progeny of polg-1 mutants arrests in the early development
Gene_expression (Progeny) of polg-1
8) Confidence 0.56 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.13 Pain Relevance 0
and for polg-1 forward 5?
Gene_expression (for) of polg-1
9) Confidence 0.56 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.26 Pain Relevance 0
Mitochondrial transcript levels in polg-1 mutants
Gene_expression (mutants) of polg-1
10) Confidence 0.56 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.66 Pain Relevance 0
However, polg-1 deficient animals could produce a handful of eggs that arrested during embryonic development.
Gene_expression (produce) of polg-1 in eggs
11) Confidence 0.56 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.06 Pain Relevance 0
Consideration of all of these reported mutations in PEO1 might be important in deciding which gene to investigate in other families presenting with adPEO.
Gene_expression (presenting) of adPEO
12) Confidence 0.51 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2579934 Disease Relevance 0.59 Pain Relevance 0.03
We recently described a knock-in mouse model that expresses an error-prone version of POLG (mtDNA mutator mice) (2).
Gene_expression (expresses) of POLG associated with targeted disruption
13) Confidence 0.50 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.34 Pain Relevance 0
Autosomal recessive PEO is rarely found.
Gene_expression (found) of PEO associated with chronic progressive external ophthalmoplegia
14) Confidence 0.49 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699981 Disease Relevance 2.15 Pain Relevance 0

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