INT138726

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.73
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Msx1) nucleus (Msx1) DNA binding (Msx1)
Anatomy Link Frequency
pigmentation 2
Msx1 (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 6 98.12 Very High Very High Very High
Central nervous system 45 95.32 Very High Very High Very High
agonist 31 83.52 Quite High
midbrain 20 82.72 Quite High
Dopamine 86 81.28 Quite High
Opioid 12 60.88 Quite High
Enkephalin 6 51.12 Quite High
Dynorphin 3 49.84 Quite Low
antagonist 30 43.68 Quite Low
Kinase C 3 19.52 Low Low
Disease Link Frequency Relevance Heat
Obesity 171 97.56 Very High Very High Very High
Appetite Loss 30 93.88 High High
Syndrome 9 83.48 Quite High
Weight Gain 12 71.92 Quite High
Cancer 2 59.36 Quite High
Ichthyosis 1 58.24 Quite High
Body Weight 9 37.12 Quite Low
Mucocutaneous Lymph Node Syndrome 1 13.64 Low Low
Anorexia 42 5.00 Very Low Very Low Very Low
Sprains And Strains 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that ultraviolet light potently induces expression of MSH in keratinocytes, but fails to stimulate pigmentation in the absence of functional MC1R in red/blonde-haired Mc1r(e/e) mice.
Positive_regulation (induces) of Gene_expression (expression) of MSH in pigmentation associated with melanocortin 1 receptor
1) Confidence 0.53 Published 2006 Journal Nature Section Abstract Doc Link 16988713 Disease Relevance 0.12 Pain Relevance 0.58
The survival of the BG02 hESC line under these conditions was very limited as compared to that of the BG01V2 and BG03 cell lines, and treatment of BG02-derived EBs with SPIE did not result in expression of Msx1.
Neg (not) Positive_regulation (result) of Gene_expression (expression) of Msx1
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.27
-MSH may be the important POMC product in inhibiting feeding centrally in humans [41], but not rodents, as rodents do not produce ?
Positive_regulation (important) of Gene_expression (product) of MSH
3) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.67 Pain Relevance 0.08
-MSH has a higher affinity for the MC4R than ?
Positive_regulation (-) of Gene_expression (has) of MSH
4) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.24 Pain Relevance 0
2-MSH reflects autostimulation of the POMC neurones projecting to the PVN, where POMC products bind to MC4R?
Positive_regulation (autostimulation) of Gene_expression (reflects) of MSH
5) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.71 Pain Relevance 0.27

General Comments

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