INT138730

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Context Info
Confidence 0.09
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.04
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
stromal cells 2
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
Dismenorea 2 95.80 Very High Very High Very High
cytokine 16 94.16 High High
rheumatoid arthritis 67 83.72 Quite High
Arthritis 64 78.16 Quite High
chemokine 2 62.32 Quite High
Inflammation 45 50.00 Quite Low
abatacept 5 50.00 Quite Low
methotrexate 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysmenorrhea 2 95.80 Very High Very High Very High
INFLAMMATION 19 95.60 Very High Very High Very High
Neutropenia 2 88.64 High High
Diarrhoea 1 87.96 High High
Rheumatoid Arthritis 68 83.72 Quite High
Arthritis 62 78.16 Quite High
Synovitis 1 54.48 Quite High
Autoimmune Disease 2 20.00 Low Low
Apoptosis 45 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to improving clinical outcomes measurements as determined by the American College of Rheumatology (ACR) criteria as early as 1 week after oral administration, R406 also reduced the level of serum IL-6 and MMP-3 (stromelysin-1) in the groups receiving 100?
Negative_regulation (reduced) of Negative_regulation (level) of IL-6
1) Confidence 0.09 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.85 Pain Relevance 0.37
Decreased suppression of interleukin-6 after treatment with medroxyprogesterone acetate and danazol in endometrial stromal cells of women with adenomyosis.
Negative_regulation (Decreased) of Negative_regulation (suppression) of interleukin-6 in stromal cells associated with dismenorea
2) Confidence 0.03 Published 2006 Journal Fertil. Steril. Section Title Doc Link 16989825 Disease Relevance 0.10 Pain Relevance 0.24
RESULTS: Following 12 months' treatment, serum levels of interleukin 6 (IL-6), soluble IL-2 receptor, C-reactive protein, soluble E-selectin, and soluble intercellular adhesion molecule-1 were significantly lower in patients receiving abatacept 10 mg/kg versus placebo.
Negative_regulation (lower) of Negative_regulation (levels) of interleukin 6
3) Confidence 0.01 Published 2006 Journal J. Rheumatol. Section Body Doc Link 17014006 Disease Relevance 0.10 Pain Relevance 0

General Comments

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