INT13875

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Context Info
Confidence 0.14
First Reported 1991
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.41
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
hypothalamus 1
spinal cord 1
PVN 1
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 3 99.74 Very High Very High Very High
antagonist 4 97.68 Very High Very High Very High
Spinal cord 5 97.56 Very High Very High Very High
Hippocampus 4 97.56 Very High Very High Very High
Clonidine 4 93.64 High High
agonist 7 93.24 High High
analgesia 1 92.92 High High
Catecholamine 1 91.88 High High
drug abuse 1 83.68 Quite High
Dopamine 6 83.56 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 2 87.16 High High
Drug Dependence 2 83.68 Quite High
Nociception 2 82.88 Quite High
Aids-related Complex 1 79.40 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results supported the previously described PVN alpha 2 adrenergic system.
Transcription (described) of PVN alpha 2 in PVN
1) Confidence 0.14 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1681082 Disease Relevance 0 Pain Relevance 0.61
No differences were found in the mRNA levels of alpha2A- and alpha2C-adrenoceptors in any of the areas examined, however F344 rats exhibited lower levels of alpha2B-adrenoceptor transcripts in the hippocampus and higher levels in the hypothalamus.
Transcription (levels) of alpha2A in hypothalamus associated with hippocampus
2) Confidence 0.02 Published 2006 Journal Life Sci. Section Abstract Doc Link 16139312 Disease Relevance 0.33 Pain Relevance 0.54
Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord.
Transcription (distribution) of alpha2A in spinal cord associated with qutenza and spinal cord
3) Confidence 0.01 Published 1998 Journal J. Neurosci. Section Title Doc Link 9671679 Disease Relevance 0 Pain Relevance 0.74
Though expression of mRNA of alpha2B-, as well as alpha2A- and alpha2C-adrenoceptor subtypes was demonstrated in gastric mucosa of the rat, the hydrophilic ST-91, given peripherally (orally, subcutaneously), failed to exert mucosal protection, in contrast with clonidine and rilmenidine which were also effective.
Transcription (expression) of alpha2A associated with clonidine
4) Confidence 0.01 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17707950 Disease Relevance 0.08 Pain Relevance 0.33

General Comments

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