INT138751

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Context Info
Confidence 0.72
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.51
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR2) signal transduction (ESR2) mitochondrion (ESR2)
nucleus (ESR2) enzyme binding (ESR2) DNA binding (ESR2)
ESR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 7 86.64 High High
agonist 12 5.00 Very Low Very Low Very Low
noradrenaline 5 5.00 Very Low Very Low Very Low
Clonidine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 130 99.56 Very High Very High Very High
Eating Disorder 5 56.52 Quite High
Diabetes Mellitus 6 47.36 Quite Low
Disorder Of Lipid Metabolism 5 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low
Thinness 2 5.00 Very Low Very Low Very Low
Dyslipidemia /

Combined Dyslipidemia

2 5.00 Very Low Very Low Very Low
Endometriosis (extended) 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Common ESR1 gene alleles are unlikely to contribute to obesity in women, whereas a minor importance of ESR2 on severe obesity cannot be excluded.
Localization (importance) of ESR2 associated with obesity
1) Confidence 0.72 Published 2007 Journal BMC Med Genet Section Body Doc Link PMC2238734 Disease Relevance 1.51 Pain Relevance 0.24
Fresh synovial tissue specimens were assessed for the localization as well as the presence of estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) by means of immunohistochemistry, as well as Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively.
Localization (localization) of ER beta
2) Confidence 0.59 Published 2006 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 16990033 Disease Relevance 0 Pain Relevance 0

General Comments

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