INT138764

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.89
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Hsf1) nucleus (Hsf1) DNA binding (Hsf1)
protein complex (Hsf1) cytoplasm (Hsf1)
Anatomy Link Frequency
heart 1
Hsf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 94 96.24 Very High Very High Very High
Inflammatory response 1 80.60 Quite High
anesthesia 7 74.88 Quite High
Inflammation 22 69.24 Quite High
rheumatoid arthritis 22 66.56 Quite High
complementary and alternative medicine 9 7.68 Low Low
cytokine 20 5.00 Very Low Very Low Very Low
methotrexate 14 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 33 100.00 Very High Very High Very High
Injury 6 98.96 Very High Very High Very High
Stress 55 98.34 Very High Very High Very High
Experimental Arthritis 48 96.24 Very High Very High Very High
Fever 12 94.72 High High
Wound Healing 1 85.72 High High
INFLAMMATION 22 80.24 Quite High
Arthritis 69 78.88 Quite High
Hypoxia 1 77.68 Quite High
Rheumatoid Arthritis 22 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of myocardial heat shock protein 72 (HSP72) postexercise is initiated by the activation of heat shock transcription factor 1 (HSF1).
Positive_regulation (activation) of HSF1 associated with shock
1) Confidence 0.69 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.44 Pain Relevance 0.05
However, it remains unknown which physiological stimuli govern myocardial HSF1 activation during exercise.
Positive_regulation (activation) of HSF1
2) Confidence 0.69 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.43 Pain Relevance 0.06
Collectively, these data suggest that HSF1 activation and HSP72 gene transcriptional competence during simulated exercise are linked to elevated heart temperature and are not a direct function of increased cardiac workload.
Positive_regulation (activation) of HSF1 in heart
3) Confidence 0.69 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.39 Pain Relevance 0.07
The expression of myocardial heat shock protein 72 (HSP72) postexercise is initiated by the activation of heat shock transcription factor 1 (HSF1).
Positive_regulation (activation) of heat shock transcription factor 1 associated with shock
4) Confidence 0.69 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.44 Pain Relevance 0.05
These experiments tested the hypothesis that thermal stress and mechanical load, concomitant with simulated exercise, provide independent stimuli for HSF1 activation and ensuing cardiac HSP72 gene expression.
Positive_regulation (activation) of HSF1 associated with stress
5) Confidence 0.69 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16990482 Disease Relevance 0.42 Pain Relevance 0.07
Taking these reports and our present data together, HSP90 is known to play an important role in the reduction of stress-induced gastric mucosal injury in females via an estrogen-HSP90 relationship with HSF1 activation.


Positive_regulation (activation) of HSF1 associated with stress and injury
6) Confidence 0.34 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901766 Disease Relevance 0.74 Pain Relevance 0
Celastrol can lead to the induction of heat-shock protein gene expression by activation of heat-shock factor-1 [14], and the enhanced response to self hsp65 can, in turn, contribute to protection against AA [23,32].
Positive_regulation (activation) of heat-shock factor-1 associated with shock and arthritis
7) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206370 Disease Relevance 1.04 Pain Relevance 0.33

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