INT138779

Context Info Confidence 0.45 First Reported 2005 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 25 Total Number 25 Disease Relevance 11.51 Pain Relevance 4.51

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6) cytoplasm (IRF6)

Anatomy Link Frequency neutrophils 6 macrophages 5 Gut 4 plasma 2 Kupffer cells 2 IRF6 (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 412 99.92 cytokine 279 99.84 corticosteroid 66 98.64 dexamethasone 43 97.80 Inflammation 506 96.50 opioid receptor 84 95.52 Kinase C inhibitor 5 88.56 cINOD 10 86.72 nud 1 85.28 abdominal pain 3 82.32

Disease Link Frequency Relevance Heat Asthma 210 99.92 Adhesions 14 99.90 Chronic Fatigue Syndrome 150 99.82 Acquired Immune Deficiency Syndrome Or Hiv Infection 32 99.70 Nicotine Addiction 233 99.56 Diabetes Mellitus 30 99.28 Mycobacterial Infection 19 97.60 Obesity 351 96.82 Immune Reconstitution Inflammatory Syndrome 31 96.68 Alcoholic Liver Diseases 19 96.56

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R,R-Glycopyrrolate alone did not affect LPS induced TNF-alpha release.

Neg (not) Positive_regulation (induced) of Localization (release) of LPS

1) Confidence 0.45 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16996482 Disease Relevance 0.69 Pain Relevance 0.27

We also show in mature human adipocytes that unlike human monocytes/macrophages (in primary culture or immortalized cell lines), the p42/44 MAP Kinase, JNK or PKA pathways are not implicated in the secretion of LPS induced TNFalpha [11-14,26,27].

Positive_regulation (induced) of Localization (secretion) of LPS in macrophages associated with obesity

2) Confidence 0.25 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.30 Pain Relevance 0

M) strongly increases the activation of LPS induced TNFalpha secretion (more than 2-fold).

Positive_regulation (induced) of Localization (secretion) of LPS

3) Confidence 0.25 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.05 Pain Relevance 0.04

M) strongly increases the activation of LPS induced TNFalpha secretion (more than 2-fold).

Positive_regulation (increases) of Localization (secretion) of LPS

4) Confidence 0.25 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.05 Pain Relevance 0.04

In the work that is presented here, we show in detail the principal activation regulation pathways of the LPS induced secretion of TNFalpha.

Positive_regulation (induced) of Localization (secretion) of LPS

5) Confidence 0.22 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.25 Pain Relevance 0

In line with this, we demonstrated a higher release of IL-8 by LPS stimulated blood cells after smoking, which may have contributed to increased neutrophil chemotaxis.

Positive_regulation (stimulated) of Localization (release) of LPS in neutrophil associated with nicotine addiction

6) Confidence 0.13 Published 2005 Journal Respir Res Section Body Doc Link PMC554761 Disease Relevance 0.81 Pain Relevance 0.03

Effects of low concentration of morphine on LPS-induced IL-8 secretion from human neutrophils were also studied.

Positive_regulation (induced) of Localization (secretion) of LPS in neutrophils associated with morphine

7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.42 Pain Relevance 1.13

The effects of the concentration of morphine found in serum of septic patients on LPS-induced release of IL-8 by human neutrophils were tested.

Positive_regulation (induced) of Localization (release) of LPS in neutrophils associated with morphine

8) Confidence 0.12 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808358 Disease Relevance 0.36 Pain Relevance 1.35

In earlier work, we showed that LPS-induced secretion of cytokines could be blocked by corticosteroids like dexamethasone [16].

Positive_regulation (induced) of Localization (secretion) of LPS associated with corticosteroid, dexamethasone and cytokine

9) Confidence 0.12 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.26 Pain Relevance 0.33

Immune reconstitution inflammatory syndrome in association with HIV/AIDS and tuberculosis: Views over hidden possibilities Gut immune components are severely compromised among persons with AIDS, which allows increased translocation of bacterial lipopolysaccharides (LPS) into the systemic circulation.

Positive_regulation (increased) of Localization (translocation) of LPS in Gut associated with mycobacterial infection, immune reconstitution inflammatory syndrome, inflammation and acquired immune deficiency syndrome or hiv infection

10) Confidence 0.11 Published 2007 Journal AIDS Res Ther Section Title Doc Link PMC2216023 Disease Relevance 1.27 Pain Relevance 0.27

IL-8 release from LPS stimulated blood cells increased more with smoking than without between 0 and 3 hours (table 3).

Positive_regulation (increased) of Localization (release) of LPS in blood cells associated with nicotine addiction

11) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC554761 Disease Relevance 1.04 Pain Relevance 0

Baseline and LPS-stimulated generation of LXA4

Positive_regulation (generation) of Localization (Baseline) of LPS

12) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.78 Pain Relevance 0.08

Cytospins were prepared and stained with Diff Quick (Harleco, Gibbstown, NJ) stain for differential cell count. 5×105 macrophages were isolated by plastic adhesion and stimulated for 18 hours with lipopolysaccaride (LPS, 10 ?

Positive_regulation (stimulated) of Localization (lipopolysaccaride) of LPS in macrophages associated with adhesions

13) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.41 Pain Relevance 0.16

We also show in mature human adipocytes that unlike human monocytes/macrophages (in primary culture or immortalized cell lines), the p42/44 MAP Kinase, JNK or PKA pathways are not implicated in the secretion of LPS induced TNFalpha [11-14,26,27].

Positive_regulation (induced) of in monocytes Localization (secretion) of LPS in macrophages associated with obesity

14) Confidence 0.09 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.30 Pain Relevance 0

This is crucial in the specific ethanol-related scenario that is often dominated by increased translocation of LPS and endotoxins from the gut to the portal circulation (and the consequent effect on Kupffer cells) and with regard to the fact that ethanol-derived oxidative stress can increase the hepatotoxic action of TNF: indeed, in either chronically ethanol fed rats or alcoholics the presence of high titres of IgG against antigens modified by lipid peroxidation or oxidative stress correlate well with increased TNF production and, quite reasonably, the severity of inflammatory infiltrate [249].

Positive_regulation (increased) of Localization (translocation) of LPS in Kupffer cells associated with stress and inflammation

15) Confidence 0.08 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.03 Pain Relevance 0.16

Side-specific LPS-stimulated IL-6 release

Positive_regulation (stimulated) of Localization (release) of LPS

16) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0 Pain Relevance 0

Cultures exposed to LPS via both the amniotic and choriodecidual compartments exhibited elevated concentrations of TNF-?

Positive_regulation (Cultures) of Localization (exposed) of LPS

17) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0 Pain Relevance 0

Side-specific LPS-stimulated IL-10 release

Positive_regulation (stimulated) of Localization (release) of LPS

18) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0 Pain Relevance 0

Whether the priming effect of PAF on LPS-induced IL-8 secretion can be explained solely by the PAF-induced higher level TLR4 expression or whether PAF also had an effect on TLR4 signaling is yet to be determined.

Positive_regulation (induced) of Localization (secretion) of LPS

19) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.41 Pain Relevance 0

Whether the priming effect of PAF on LPS-induced IL-8 secretion can be explained solely by the PAF-induced higher level TLR4 expression or whether PAF also had an effect on TLR4 signaling is yet to be determined.

Positive_regulation (explained) of Localization (secretion) of LPS

20) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.46 Pain Relevance 0

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