INT13878

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Context Info
Confidence 0.33
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.85
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a2) enzyme binding (Ugt1a2)
Anatomy Link Frequency
leukocyte 2
platelet 1
Ugt1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 8 100.00 Very High Very High Very High
b2 receptor 1 100.00 Very High Very High Very High
central sensitization 2 99.64 Very High Very High Very High
qutenza 4 98.80 Very High Very High Very High
bradykinin 12 96.60 Very High Very High Very High
Inflammatory mediators 1 96.28 Very High Very High Very High
Inflammation 26 95.52 Very High Very High Very High
Spinal cord 4 94.16 High High
nociceptor 2 92.00 High High
intrathecal 1 91.28 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 99.60 Very High Very High Very High
Pressure Volume 2 Under Development 4 99.36 Very High Very High Very High
Thyroid Disease 4 97.46 Very High Very High Very High
INFLAMMATION 24 96.28 Very High Very High Very High
Pressure And Volume Under Development 2 90.12 High High
Increased Venous Pressure Under Development 4 87.84 High High
Nociception 1 87.72 High High
Cv General 3 Under Development 2 87.16 High High
Hyperalgesia 1 86.20 High High
Pain 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Misoprostol, when used alone, decreased exudate thromboxane B2 level significantly.
Negative_regulation (decreased) of B2
1) Confidence 0.33 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10225376 Disease Relevance 0.30 Pain Relevance 0.22
Administration of indomethacin (0.25 to 4 mg/kg) 1 h before carrageenan given by the orogastric route reduced the exudate leukocyte count and thromboxane B2 level whereas it increased the exudate leukotriene B4 level dose dependently.
Negative_regulation (reduced) of B2 in leukocyte
2) Confidence 0.33 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10225376 Disease Relevance 0.17 Pain Relevance 0.09
Hypothyroidism induced by iodine 131 (given at age 7 weeks) persistently caused a mild decrease in platelet count (P less than 0.01) and 30% decrease in immunoreactive thromboxane B2 (the hydrolysis product of thromboxane A2) generation per platelet (P less than 0.01) compared with age-matched euthyroid rats.
Negative_regulation (decrease) of B2 in platelet associated with thyroid disease
3) Confidence 0.25 Published 1987 Journal J. Lab. Clin. Med. Section Abstract Doc Link 3668359 Disease Relevance 0.81 Pain Relevance 0.17
Compound I-3 inhibited both thromboxane B2 and prostaglandin I2 formation, suggesting that it has an inhibitory effect on cyclooxygenase.
Negative_regulation (inhibited) of B2
4) Confidence 0.23 Published 1989 Journal Chem. Pharm. Bull. Section Abstract Doc Link 2502320 Disease Relevance 0 Pain Relevance 0.12
B1, B2, or CGRP1 receptor antagonists or desensitization attenuated the transient hypotension and plasma protein and leukocyte infiltration of intestinal wall observed during post-ischemic reperfusion.
Negative_regulation (desensitization) of B2 in leukocyte associated with pressure volume 2 under development and antagonist
5) Confidence 0.20 Published 2001 Journal Peptides Section Abstract Doc Link 11390021 Disease Relevance 0.17 Pain Relevance 0.51
Pergolide treatment also did not decrease thromboxane B2, prostaglandin E2 or leukotriene B4 production, ruling out direct effects on arachnoid acid inflammatory mediators.
Neg (not) Negative_regulation (decrease) of B2 associated with inflammatory mediators
6) Confidence 0.18 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1681083 Disease Relevance 0.66 Pain Relevance 0.64
These effects were abolished by the combination of B2 and CGRP1 blockade as well as by B2 antagonism in capsaicinized rats, while NK1 blockade was ineffective.
Negative_regulation (blockade) of B2
7) Confidence 0.10 Published 2001 Journal Peptides Section Abstract Doc Link 11390021 Disease Relevance 0.18 Pain Relevance 0.47
Primary afferent-evoked central sensitization is, in addition, reduced in B2 receptor knock-out mice.
Negative_regulation (reduced) of B2 associated with targeted disruption, central sensitization and b2 receptor
8) Confidence 0.10 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16135755 Disease Relevance 0.56 Pain Relevance 1.28
In contrast to laccase and bilirubin oxidase, PPO could efficiently operate at pH 7 and was not inhibited by products present in physiological fluids.
Negative_regulation (inhibited) of bilirubin oxidase
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864295 Disease Relevance 0 Pain Relevance 0

General Comments

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