INT138784

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.44
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) extracellular space (Lcn2) extracellular region (Lcn2)
Anatomy Link Frequency
Leukocyte 6
neurons 2
Lcn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 2 99.48 Very High Very High Very High
allodynia 1 99.40 Very High Very High Very High
Dorsal horn neuron 6 99.04 Very High Very High Very High
Hyperalgesia 3 98.24 Very High Very High Very High
Inflammatory response 16 95.12 Very High Very High Very High
intrathecal 2 95.00 High High
Inflammation 29 94.32 High High
Dorsal horn 1 91.04 High High
Pain 1 75.44 Quite High
adenocard 8 42.36 Quite Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 20 99.52 Very High Very High Very High
Cv Unclassified Under Development 2 99.48 Very High Very High Very High
Neuropathic Pain 1 99.40 Very High Very High Very High
Renal Disease 4 99.04 Very High Very High Very High
Ocular Hypertension 1 98.76 Very High Very High Very High
Increased Venous Pressure Under Development 72 98.34 Very High Very High Very High
Hyperalgesia 3 98.24 Very High Very High Very High
Injury 56 97.28 Very High Very High Very High
Pressure Volume 2 Under Development 12 96.84 Very High Very High Very High
Lung Injury 140 96.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found an increase in NGAL tubular expression in rats ventilated with high Vt+Vehicle compared with those ventilated with low Vt+Vehicle, which was blunted by the administration of WW85 or PJ-34 (Figure 6b).
Positive_regulation (increase) of Gene_expression (expression) of NGAL
1) Confidence 0.49 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.34 Pain Relevance 0
Leukocyte accumulation and NGAL expression, detected predominantly in proximal tubule cells in response to tubular epithelial damage, are commonly observed in models of renal injury and dysfunction [43,44].
Positive_regulation (accumulation) of Gene_expression (expression) of NGAL in Leukocyte associated with injury
2) Confidence 0.35 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.62 Pain Relevance 0.08
Leukocyte accumulation and NGAL expression in renal tissue
Positive_regulation (accumulation) of Gene_expression (expression) of NGAL in Leukocyte
3) Confidence 0.35 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.40 Pain Relevance 0
High tidal volume ventilation resulted in lung injury, hypotension, renal hypoperfusion and impaired renal endothelium-dependent vasodilation, associated with renal dysfunction and tissue changes (leukocyte accumulation and increased expression of neutrophil gelatinase-associated lipocalin).
Positive_regulation (increased) of Gene_expression (expression) of gelatinase-associated lipocalin in leukocyte associated with lung injury, pressure volume 2 under development, renal disease and increased venous pressure under development
4) Confidence 0.33 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887157 Disease Relevance 0.78 Pain Relevance 0
In contrast, overexpression of Cdk5, p35 or p25 in primary sensory and dorsal horn neurons significantly enhanced heat hyperalgesia.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p25 in neurons associated with hyperalgesia and dorsal horn neuron
5) Confidence 0.31 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.44 Pain Relevance 0.91
An increase of Clusterin and Lipocalin 2 expression together with that of ceruloplasmin and early growth response 1 (Egr1) is associated with increased apoptosis and immune-inflammatory responses [41,42].
Positive_regulation (increase) of Gene_expression (expression) of Lipocalin 2 associated with inflammatory response and apoptosis
6) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.86 Pain Relevance 0.14

General Comments

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