INT138785

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 17
Disease Relevance 9.88
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) extracellular space (Lcn2) extracellular region (Lcn2)
Anatomy Link Frequency
neutrophil 4
Leukocyte 3
neurons 2
urine 2
liver 1
Lcn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 12 99.84 Very High Very High Very High
allodynia 2 99.40 Very High Very High Very High
ischemia 8 98.44 Very High Very High Very High
Hyperalgesia 6 98.24 Very High Very High Very High
Inflammatory response 31 95.12 Very High Very High Very High
intrathecal 4 95.00 High High
Inflammation 61 93.64 High High
Dorsal horn 2 91.04 High High
anesthesia 17 84.96 Quite High
Pain 2 75.44 Quite High
Disease Link Frequency Relevance Heat
Injury 126 100.00 Very High Very High Very High
Renal Disease 15 99.64 Very High Very High Very High
Neuropathic Pain 2 99.40 Very High Very High Very High
Disorders Of Creatine Metabolism 45 98.84 Very High Very High Very High
Cv Unclassified Under Development 8 98.44 Very High Very High Very High
Hyperalgesia 6 98.24 Very High Very High Very High
Increased Venous Pressure Under Development 162 98.14 Very High Very High Very High
Ocular Hypertension 1 97.72 Very High Very High Very High
Pressure Volume 2 Under Development 27 96.64 Very High Very High Very High
Lung Injury 315 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The difference between the NGAL concentration 2 hours after reperfusion and the baseline NGAL concentration was predictive of AKI in all patients, including patients with preexisting renal dysfunction.
Gene_expression (concentration) of NGAL associated with renal disease and injury
1) Confidence 0.56 Published 2009 Journal Liver Transpl. Section Abstract Doc Link 19938135 Disease Relevance 1.09 Pain Relevance 0.08
The difference between the NGAL concentration 2 hours after reperfusion and the baseline NGAL concentration was predictive of AKI in all patients, including patients with preexisting renal dysfunction.
Gene_expression (concentration) of NGAL associated with renal disease and injury
2) Confidence 0.56 Published 2009 Journal Liver Transpl. Section Abstract Doc Link 19938135 Disease Relevance 1.09 Pain Relevance 0.08
The degree of renal dysfunction was evaluated by measuring neutrophil gelatinase-associated lipocalin (NGAL) in the spot urine samples.
Gene_expression (measuring) of neutrophil gelatinase-associated lipocalin in urine associated with renal disease
3) Confidence 0.56 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20808070 Disease Relevance 0.54 Pain Relevance 0.18
The degree of renal dysfunction was evaluated by measuring neutrophil gelatinase-associated lipocalin (NGAL) in the spot urine samples.
Gene_expression (measuring) of NGAL in urine associated with renal disease
4) Confidence 0.56 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20808070 Disease Relevance 0.54 Pain Relevance 0.18
Leukocyte accumulation and NGAL expression in renal tissue
Gene_expression (expression) of NGAL in Leukocyte
5) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.39 Pain Relevance 0
Indeed, in our study, we can not exclude also an endothelial expression of NGAL.
Gene_expression (expression) of NGAL
6) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.66 Pain Relevance 0.10
Leukocyte accumulation and NGAL expression, detected predominantly in proximal tubule cells in response to tubular epithelial damage, are commonly observed in models of renal injury and dysfunction [43,44].
Gene_expression (expression) of NGAL in Leukocyte associated with injury
7) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.61 Pain Relevance 0.08
We found an increase in NGAL tubular expression in rats ventilated with high Vt+Vehicle compared with those ventilated with low Vt+Vehicle, which was blunted by the administration of WW85 or PJ-34 (Figure 6b).
Gene_expression (expression) of NGAL
8) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.29 Pain Relevance 0
Common leukocyte antigen CD45 (AbD Serotec, Düsseldorf, Germany) or neutrophil gelatinase-associated lipocalin (NGAL) (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA) antibody was incubated 1: 25 in PBS overnight at 4°C and washed three times in PBS with 0.05% Tween (PBST, Sigma-Aldrich, St.
Gene_expression (neutrophil) of NGAL in neutrophil
9) Confidence 0.54 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.08 Pain Relevance 0
Common leukocyte antigen CD45 (AbD Serotec, Düsseldorf, Germany) or neutrophil gelatinase-associated lipocalin (NGAL) (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA) antibody was incubated 1: 25 in PBS overnight at 4°C and washed three times in PBS with 0.05% Tween (PBST, Sigma-Aldrich, St.
Gene_expression (leukocyte) of gelatinase-associated lipocalin in neutrophil
10) Confidence 0.47 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.08 Pain Relevance 0
Common leukocyte antigen CD45 (AbD Serotec, Düsseldorf, Germany) or neutrophil gelatinase-associated lipocalin (NGAL) (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA) antibody was incubated 1: 25 in PBS overnight at 4°C and washed three times in PBS with 0.05% Tween (PBST, Sigma-Aldrich, St.
Gene_expression (neutrophil) of gelatinase-associated lipocalin in neutrophil
11) Confidence 0.47 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.08 Pain Relevance 0
Common leukocyte antigen CD45 (AbD Serotec, Düsseldorf, Germany) or neutrophil gelatinase-associated lipocalin (NGAL) (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA) antibody was incubated 1: 25 in PBS overnight at 4°C and washed three times in PBS with 0.05% Tween (PBST, Sigma-Aldrich, St.
Gene_expression (antigen) of gelatinase-associated lipocalin in neutrophil
12) Confidence 0.47 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.08 Pain Relevance 0
High tidal volume ventilation resulted in lung injury, hypotension, renal hypoperfusion and impaired renal endothelium-dependent vasodilation, associated with renal dysfunction and tissue changes (leukocyte accumulation and increased expression of neutrophil gelatinase-associated lipocalin).
Gene_expression (expression) of gelatinase-associated lipocalin in leukocyte associated with lung injury, pressure volume 2 under development, renal disease and increased venous pressure under development
13) Confidence 0.42 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887157 Disease Relevance 0.78 Pain Relevance 0
In contrast, overexpression of Cdk5, p35 or p25 in primary sensory and dorsal horn neurons significantly enhanced heat hyperalgesia.
Gene_expression (overexpression) of p25 in neurons associated with hyperalgesia and dorsal horn neuron
14) Confidence 0.35 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.44 Pain Relevance 0.91
The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative of p35, could only be detected in the dorsal horn neurons.
Gene_expression (detected) of p25 in neurons associated with dorsal horn neuron
15) Confidence 0.35 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.26 Pain Relevance 0.50
Innovative technologies such as functional genomics and proteomics have facilitated detection of several promising early biomarkers of AKI, such as neutrophil gelatinase-associated lipocalin (NGAL), cystatin C (CyC), liver-type fatty acid binding protein (L-FABP), interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1).
Gene_expression (detection) of NGAL in liver associated with injury
16) Confidence 0.14 Published 2010 Journal Minerva Anestesiol Section Abstract Doc Link 20473256 Disease Relevance 1.01 Pain Relevance 0.16
An increase of Clusterin and Lipocalin 2 expression together with that of ceruloplasmin and early growth response 1 (Egr1) is associated with increased apoptosis and immune-inflammatory responses [41,42].
Gene_expression (expression) of Lipocalin 2 associated with inflammatory response and apoptosis
17) Confidence 0.10 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.84 Pain Relevance 0.14

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