INT138786

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.41
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Lcn2) extracellular space (Lcn2) extracellular region (Lcn2)
Anatomy Link Frequency
neurons 1
dorsal horn 1
Lcn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 12 99.84 Very High Very High Very High
Dorsal horn 2 99.68 Very High Very High Very High
intrathecal 4 98.32 Very High Very High Very High
ischemia 2 97.40 Very High Very High Very High
Hyperalgesia 6 85.04 High High
allodynia 2 82.48 Quite High
Inflammatory response 4 79.52 Quite High
Inflammation 7 75.00 Quite High
Angina 6 75.00 Quite High
Pain 2 53.28 Quite High
Disease Link Frequency Relevance Heat
Injury 32 99.60 Very High Very High Very High
Ocular Hypertension 1 98.60 Very High Very High Very High
Cv General 3 Under Development 6 97.72 Very High Very High Very High
Cv Unclassified Under Development 2 97.40 Very High Very High Very High
Diabetes Mellitus 2 95.28 Very High Very High Very High
Renal Disease 6 94.64 High High
Optic Nerve Injuries 34 94.48 High High
Retina Disease 4 86.08 High High
Hyperalgesia 6 85.04 High High
Death 51 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Persistently increased urinary NGAL and L-FABP may suggest renotubular damage in this population.


Positive_regulation (increased) of NGAL
1) Confidence 0.51 Published 2009 Journal Adv Med Sci Section Body Doc Link 19875355 Disease Relevance 0.08 Pain Relevance 0
We found 90% sensitivity and 74% specificity of serum and 76% sensitivity and 80% specificity of urinary NGAL increase.
Positive_regulation (increase) of NGAL
2) Confidence 0.41 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17566573 Disease Relevance 0.32 Pain Relevance 0.07
We found a significant rise in serum NGAL after 2, 4 and 8 h, and in urinary NGAL after 4, 8 and 24 h after PCI.
Positive_regulation (rise) of NGAL
3) Confidence 0.41 Published 2008 Journal Int. J. Cardiol. Section Abstract Doc Link 17566573 Disease Relevance 0.34 Pain Relevance 0.07
MATERIAL AND METHODS: We measured serum NGAL, urinary NGAL and L-FABP using commercially available kits before and after 2, 4, 12, 24 and 48 hours following PCI in 25 patients.
Positive_regulation (urinary) of NGAL
4) Confidence 0.37 Published 2009 Journal Adv Med Sci Section Body Doc Link 19875355 Disease Relevance 0.10 Pain Relevance 0
The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative of p35, could only be detected in the dorsal horn neurons.
Positive_regulation (derivative) of p25 in neurons associated with dorsal horn neuron
5) Confidence 0.22 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.26 Pain Relevance 0.49
Cdk5 activation in DRG neurons required p35, whereas p25 was required in the dorsal horn.
Positive_regulation (required) of p25 in dorsal horn associated with dorsal horn
6) Confidence 0.22 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.39 Pain Relevance 0.82
Interestingly, clusterin, lipocalin 2, litaf, and TNFR1a are also upregulated by other injuries as elevation of intraocular pressure (IOP) or ischemia [36-40].
Positive_regulation (upregulated) of lipocalin 2 associated with ischemia, injury and ocular hypertension
7) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.93 Pain Relevance 0.12

General Comments

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