INT138789

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Context Info
Confidence 0.76
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 5.19
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (Cdk5) cytoplasm (Cdk5) cytosol (Cdk5)
nucleocytoplasmic transport (Cdk5) cell death (Cdk5) nucleolus (Cdk5)
Anatomy Link Frequency
Nerve 2
neurons 2
neuronal 1
descending colon 1
Cdk5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 14 100.00 Very High Very High Very High
Nerve growth factor 10 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
allodynia 2 99.40 Very High Very High Very High
Dorsal horn neuron 12 99.04 Very High Very High Very High
Pain 6 98.64 Very High Very High Very High
Hyperalgesia 6 98.24 Very High Very High Very High
Spinal cord 2 96.88 Very High Very High Very High
Action potential 1 95.44 Very High Very High Very High
intrathecal 4 95.00 High High
Disease Link Frequency Relevance Heat
Cancer 36 100.00 Very High Very High Very High
Necrosis 28 100.00 Very High Very High Very High
Alzheimer's Dementia 22 99.80 Very High Very High Very High
Neuropathic Pain 4 99.40 Very High Very High Very High
Pain 6 98.64 Very High Very High Very High
Apoptosis 32 98.52 Very High Very High Very High
Hyperalgesia 6 98.24 Very High Very High Very High
Neurodegenerative Disease 13 95.88 Very High Very High Very High
Dementia 1 93.52 High High
INFLAMMATION 16 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative of p35, could only be detected in the dorsal horn neurons.
Gene_expression (expressed) of Cdk5 in neurons associated with dorsal horn neuron
1) Confidence 0.76 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.15 Pain Relevance 0.37
In contrast, overexpression of Cdk5, p35 or p25 in primary sensory and dorsal horn neurons significantly enhanced heat hyperalgesia.
Gene_expression (overexpression) of Cdk5 in neurons associated with hyperalgesia and dorsal horn neuron
2) Confidence 0.76 Published 2007 Journal Pain Section Abstract Doc Link 16996690 Disease Relevance 0.44 Pain Relevance 0.91
The present data indicate a novel target to express the action of Cdk5 on membrane proteins involved in pain perception.
Gene_expression (express) of Cdk5 associated with pain
3) Confidence 0.60 Published 2010 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 19960242 Disease Relevance 0.31 Pain Relevance 0.24
When compared with a baseline reflex activity with a single action potential evoked by the TS before the administration of test agents, MO instillation into the descending colon sensitized the evoked activity characterized by elongated firing in the reflex activity in association with increased protein levels of Cdk5, PSD95, and phosphorylated NR2B (pNR2B) but not of total NR2B (tNR2B) in the spinal cord tissue.
Gene_expression (levels) of Cdk5 in descending colon associated with action potential and spinal cord
4) Confidence 0.57 Published 2009 Journal Pain Section Abstract Doc Link 19167822 Disease Relevance 0.23 Pain Relevance 0.45
Finally, treatment with phenelzine resulted in up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Fyn proto-oncogene), 14 (Nerve growth factor beta, Midkine, Type 1 tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Leptin receptor, Adrenomedullin, Arrestin beta 1, Syntaxin 1A, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, Growth differentiation factor 15, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of four (Immunoglobulin superfamily member 6, Secreted phosphoprotein 1, Phospholipase A2 activating protein, Tumor necrosis factor receptor superfamily member 6), three (Serum amyloid A 4, Apoptosis facilitator Bcl-2-like protein 14, Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after treatment for one, three and seven days, respectively (Table 1 and 2).
Gene_expression (expressed) of Cyclin-dependent kinase 5 in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and apoptosis
5) Confidence 0.49 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.64 Pain Relevance 0.25
Treatment with imipramine resulted in significant up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Tumor necrosis factor member 11), 13 (Nerve growth factor beta, tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Neurotrophic tyrosine kinase receptor type 2, Somatostatin receptor 5, Leptin receptor, Arrestin beta 1, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, RAB6A member RAS oncogene family, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of five (Leukocyte cell derived chemotaxin 1, Phospholipase A2 activating protein, Mitogen-activated protein kinase), one (Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after one, three and seven days of treatment, respectively.
Gene_expression (expressed) of Cyclin-dependent kinase 5 in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and somatostatin
6) Confidence 0.49 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.37 Pain Relevance 0.29
Cyclin-dependent kinase 5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells.
Gene_expression (over-expression) of Cyclin-dependent kinase 5 in neuronal associated with alzheimer's dementia and apoptosis
7) Confidence 0.11 Published 2009 Journal Neuroscience Section Title Doc Link 19362124 Disease Relevance 1.04 Pain Relevance 0.12

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