INT138799

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 7
Reported most in Body
Documents 40
Total Number 47
Disease Relevance 29.42
Pain Relevance 6.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
lipid metabolic process (Ppara)
Anatomy Link Frequency
macrophages 10
livers 6
intestinal cells 2
photoreceptors 2
nucleus 2
Ppara (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 816 100.00 Very High Very High Very High
agonist 768 100.00 Very High Very High Very High
cINOD 81 99.84 Very High Very High Very High
Neuropathic pain 2 99.48 Very High Very High Very High
antagonist 34 99.12 Very High Very High Very High
Eae 4 98.96 Very High Very High Very High
ischemia 29 98.32 Very High Very High Very High
Spinal cord 13 97.04 Very High Very High Very High
cytokine 193 96.72 Very High Very High Very High
Inflammatory marker 4 89.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 921 100.00 Very High Very High Very High
Cancer 693 100.00 Very High Very High Very High
Obesity 329 100.00 Very High Very High Very High
Ocular & Orbital Inflammation 2 99.88 Very High Very High Very High
Stress 230 99.72 Very High Very High Very High
Colitis 80 99.60 Very High Very High Very High
Neuropathic Pain 2 99.48 Very High Very High Very High
Shock 766 99.20 Very High Very High Very High
Injury 154 98.96 Very High Very High Very High
Disease 226 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
showed inversed phase in response to daytime feeding corresponding to altered expression of PPAR?
Regulation (altered) of Gene_expression (expression) of PPAR
1) Confidence 0.60 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.10
ligand on STAT3 activity depend directly on the expression and activation of PPAR-?
Regulation (depend) of Gene_expression (expression) of PPAR
2) Confidence 0.54 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.36 Pain Relevance 0.14
The effects of monotherapy with selective PPAR agonists,
Regulation (effects) of Gene_expression (agonists) of PPAR associated with agonist
3) Confidence 0.45 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 0.59 Pain Relevance 0.15
three PPAR isoforms serve to modulate food intake and energy
Regulation (three) of Gene_expression (isoforms) of PPAR
4) Confidence 0.45 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 0.78 Pain Relevance 0.22
three PPAR isoforms serve to modulate food intake and energy
Regulation (modulate) of Gene_expression (isoforms) of PPAR
5) Confidence 0.45 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 0.79 Pain Relevance 0.22
In addition to modulating nociception, GW7647 and PEA reduced hyperalgesic responses in the chronic constriction injury model of neuropathic pain; these effects were also contingent on PPAR-alpha expression and were observed following either acute or subchronic PPAR-alpha agonist administration.
Regulation (contingent) of Gene_expression (expression) of PPAR-alpha associated with nociception, hyperalgesia, eae, injury, agonist and neuropathic pain
6) Confidence 0.45 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16997973 Disease Relevance 0.66 Pain Relevance 0.66
anti-inflammatory effect of PPAR agonists observed in
Regulation (effect) of Gene_expression (agonists) of PPAR associated with inflammation and agonist
7) Confidence 0.45 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.46 Pain Relevance 0.54
residual anti-inflammatory effect of PPAR agonists observed in
Regulation (effect) of Gene_expression (agonists) of PPAR associated with inflammation and agonist
8) Confidence 0.45 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.58 Pain Relevance 0.66
Circadian clock proteins control PPARs expression by at least two mechanisms: (1) activation of PPAR?
Regulation (control) of Gene_expression (expression) of PPAR
9) Confidence 0.44 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0 Pain Relevance 0.04
These cells, which participate in ocular inflammation, are controlled in their functions by PPAR-?
Regulation (functions) of Gene_expression (controlled) of PPAR associated with inflammation and ocular & orbital inflammation
10) Confidence 0.44 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2964958 Disease Relevance 1.40 Pain Relevance 0.48
been found in numerous PPAR-inducible genes, including acyl-CoA oxidase (ACO)
Regulation (numerous) of Gene_expression (genes) of PPAR-inducible
11) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0 Pain Relevance 0
In the present study, we hypothesized that there were interactions on a genetic level between PPAR?
Regulation (were) of Gene_expression (level) of PPAR
12) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.83 Pain Relevance 0.13
Our previous experiments indicated that WY had minimal effects in the livers of PPAR?
Regulation (effects) of Gene_expression (livers) of PPAR in livers
13) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.64 Pain Relevance 0
Although the possible carcinogenic or toxic effects of PPAR activation remain
Spec (possible) Regulation (effects) of Gene_expression (activation) of PPAR
14) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 1.00 Pain Relevance 0.13
The bases of the protective action of PPAR?
Regulation (bases) of Gene_expression (action) of PPAR
15) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 1.57 Pain Relevance 0.40
approaches to determining the function of PPAR?
Spec (determining) Regulation (determining) of Gene_expression (function) of PPAR
16) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.61 Pain Relevance 0.18
contradicting the notion that PPAR?
Regulation (contradicting) of Gene_expression (notion) of PPAR
17) Confidence 0.40 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 1.10 Pain Relevance 0.04
The exact mechanism through which PPAR-?
Regulation (through) of Gene_expression (mechanism) of PPAR
18) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.37 Pain Relevance 0.18
Many molecular mechanisms and cellular targets play a role in controlling colonic inflammation by PPAR expression and activation in epithelial and various types of immune cells, especially macrophages.
Regulation (controlling) of Gene_expression (expression) of PPAR in macrophages associated with inflammation
19) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.91 Pain Relevance 0.24
By normalizing PPAR expression, 5-ASA elevated STAT3 protein levels (nucleus and cytosol).
Regulation (normalizing) of Gene_expression (expression) of PPAR in nucleus
20) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.52 Pain Relevance 0.10

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