INT1388

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Context Info
Confidence 0.35
First Reported 1977
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.17
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl, Gnrh1) extracellular space (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
follicle 2
Prl (Rattus norvegicus)
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 1 77.08 Quite High
opiate 1 31.60 Quite Low
antagonist 79 31.04 Quite Low
narcan 3 30.16 Quite Low
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 54 5.00 Very Low Very Low Very Low
cytokine 44 5.00 Very Low Very Low Very Low
agonist 44 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 34 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Galactorrhea 7 94.92 High High
Stress 96 5.00 Very Low Very Low Very Low
INFLAMMATION 56 5.00 Very Low Very Low Very Low
Cancer 44 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low
Starvation 20 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 16 5.00 Very Low Very Low Very Low
Natriuresis 14 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have investigated the actions of PRL on the secretion of LHRH and LH and the interaction among PRL, beta-endorphin (beta-EP), and LHRH.
PRL Binding (interaction) of LHRH
1) Confidence 0.35 Published 1985 Journal Endocrinology Section Abstract Doc Link 3157564 Disease Relevance 0.17 Pain Relevance 0
Contrary to findings with LHRH and LH, repeated injections of a small dose (10 ng) of TRH in the afternoon of proestrus abolished PRL and TSH responses to subsequent injection of the neurohormone.
PRL Binding (findings) of LHRH
2) Confidence 0.30 Published 1977 Journal Endocrinology Section Abstract Doc Link 192538 Disease Relevance 0 Pain Relevance 0.08
In 1970, Nakane (83) was the first to report that, indeed, growth hormone (GH), prolactin (PRL), adrenocorticotrophic hormone (ACTH) and thyroid-stimulating hormone (TSH) were stored in separate cell types but that many gonadotrophs showed immunoreactivity for both luteinising hormone (LH) and follicle-stimulating hormone (FSH).
prolactin Binding (immunoreactivity) of luteinising hormone in follicle
3) Confidence 0.12 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
In 1970, Nakane (83) was the first to report that, indeed, growth hormone (GH), prolactin (PRL), adrenocorticotrophic hormone (ACTH) and thyroid-stimulating hormone (TSH) were stored in separate cell types but that many gonadotrophs showed immunoreactivity for both luteinising hormone (LH) and follicle-stimulating hormone (FSH).
PRL Binding (immunoreactivity) of luteinising hormone in follicle
4) Confidence 0.12 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0

General Comments

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