INT138815

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.06
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (COX5A) small molecule metabolic process (COX5A)
Anatomy Link Frequency
platelets 3
vasculature 1
COX5A (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 4 99.92 Very High Very High Very High
Potency 5 98.84 Very High Very High Very High
cINOD 4 97.60 Very High Very High Very High
Neuropathic pain 1 96.92 Very High Very High Very High
Pain 2 96.72 Very High Very High Very High
Inflammation 5 96.36 Very High Very High Very High
Arthritis 1 92.56 High High
Hyperalgesia 1 89.52 High High
COX-2 inhibitor 2 75.00 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 97.04 Very High Very High Very High
Neuropathic Pain 1 96.92 Very High Very High Very High
Pain 2 96.72 Very High Very High Very High
Arthritis 2 92.56 High High
Hyperalgesia 1 89.52 High High
Pressure And Volume Under Development 1 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This compound's unique chemical structure and effect on COX enzyme binding and activity as well as its potency and selectivity may prove useful in treating pain and inflammation.
Regulation (effect) of COX Binding (binding) of associated with pain, inflammation and potency
1) Confidence 0.44 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18457826 Disease Relevance 0.86 Pain Relevance 0.70
Modulation of the interaction between COX products of the vasculature and platelets underlies both the cardioprotection afforded by aspirin and the cardiovascular hazard which characterises specific inhibitors of COX-2.
Regulation (Modulation) of COX Binding (interaction) of in platelets associated with aspirin
2) Confidence 0.26 Published 2006 Journal Handb Exp Pharmacol Section Abstract Doc Link 16999220 Disease Relevance 0.10 Pain Relevance 0.29
Modulation of the interaction between COX products of the vasculature and platelets underlies both the cardioprotection afforded by aspirin and the cardiovascular hazard which characterises specific inhibitors of COX-2.
Regulation (Modulation) of COX in vasculature Binding (interaction) of in platelets associated with aspirin
3) Confidence 0.09 Published 2006 Journal Handb Exp Pharmacol Section Abstract Doc Link 16999220 Disease Relevance 0.10 Pain Relevance 0.29

General Comments

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