INT138833

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Context Info
Confidence 0.46
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 16.08
Pain Relevance 6.40

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cytosol (MTHFR) small molecule metabolic process (MTHFR) oxidoreductase activity (MTHFR)
cellular amino acid metabolic process (MTHFR)
Anatomy Link Frequency
head 2
leukocyte 1
B12 1
MTHFR (Homo sapiens)
MTHFR - C677T (8)
Pain Link Frequency Relevance Heat
Migraine 570 100.00 Very High Very High Very High
depression 94 100.00 Very High Very High Very High
Inflammation 20 98.96 Very High Very High Very High
cannabis 2 98.88 Very High Very High Very High
headache 108 98.52 Very High Very High Very High
metalloproteinase 2 97.04 Very High Very High Very High
Serotonin 2 74.96 Quite High
Dopamine 10 73.76 Quite High
monoamine 4 73.08 Quite High
cytokine 6 72.32 Quite High
Disease Link Frequency Relevance Heat
Headache 642 100.00 Very High Very High Very High
Depression 144 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 40 100.00 Very High Very High Very High
Embolism 10 99.92 Very High Very High Very High
Inflammatory Bowel Disease 47 99.24 Very High Very High Very High
Cardiovascular Disease 36 99.20 Very High Very High Very High
Nicotine Addiction 36 98.52 Very High Very High Very High
Stress 36 98.32 Very High Very High Very High
Epilepsy 31 98.20 Very High Very High Very High
Hemolysis 27 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the 50 variables tested and after Bonferroni correction for multiple testing, migraine diagnosis (P < 0.0001, degree of freedom (df) = 2), unilateral head pain (P = 0.002, df = 2), physical activity discomforts (P < 0.001, df = 2) and stress as a migraine trigger (P = 0.002, df = 2) were all factors that were significantly associated with MTHFR genotype (Table 2).
MTHFR Binding (associated) of in head associated with stress, migraine and headache
1) Confidence 0.46 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 1.42 Pain Relevance 0.72
We examined the association between MTHFR C677T genotype, tHcy and clinical history of ever depression in the Health in Men Study (HIMS) cohort [5].
MTHFR (C677T) Spec (examined) Binding (association) of associated with depression
2) Confidence 0.37 Published 2010 Journal Trials Section Body Doc Link PMC2822769 Disease Relevance 0.46 Pain Relevance 0.34
We then conducted a meta-analysis of studies investigating the association between depression and MTHFR genotype, including our own data from HIMS.
MTHFR Binding (association) of associated with depression
3) Confidence 0.37 Published 2010 Journal Trials Section Body Doc Link PMC2822769 Disease Relevance 0.56 Pain Relevance 0.37
To test for association of the MTHFR C677T variant to migraine, we utilised a combination of traditional and modern case-control study designs.
MTHFR C677T (C677T) Binding (association) of associated with migraine
4) Confidence 0.37 Published 2004 Journal BMC Med Section Body Doc Link PMC375543 Disease Relevance 1.37 Pain Relevance 0.46
These researchers reported that the MTHFR C677T is associated with migraine and also indicated that the T/T genotype specifically increased risk of MA (OR ~10).
MTHFR C677T (C677T) Binding (associated) of associated with migraine with aura and migraine
5) Confidence 0.37 Published 2004 Journal BMC Med Section Body Doc Link PMC375543 Disease Relevance 1.08 Pain Relevance 0.66
That is, inheritance phase was indiscernible in many families and therefore the power to detect the expected association of the MTHFR C677T variant and migraine, as detected in the unrelated case-control analysis, was severely diminished.
MTHFR C677T (C677T) Binding (association) of associated with migraine
6) Confidence 0.37 Published 2004 Journal BMC Med Section Body Doc Link PMC375543 Disease Relevance 0.62 Pain Relevance 0.26
BACKGROUND: Data on the association between the MTHFR 677C>T and ACE D/I polymorphisms and migraine including aura status are conflicting.
MTHFR Binding (association) of associated with epilepsy and migraine
7) Confidence 0.36 Published 2010 Journal Headache Section Abstract Doc Link 19925624 Disease Relevance 0.27 Pain Relevance 0.17
In contrast others showed no association between the MTHFR C677T mutation and CVD [29].
MTHFR (C677T) Neg (no) Binding (association) of associated with cardiovascular disease
8) Confidence 0.36 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570578 Disease Relevance 1.53 Pain Relevance 0.29
Even after correction for multiple testing, analyses indicated the MTHFR genotype to be significantly associated with migraine diagnosis, unilateral head pain, physical activity discomforts, and stress as a migraine trigger.
MTHFR Binding (associated) of in head associated with stress, migraine and headache
9) Confidence 0.35 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 1.68 Pain Relevance 0.99
A genetic association study by Kowa et al. (2000) [31], originally reported a positive association between the MTHFR C677T variant and migraine in a Japanese case-control cohort.
MTHFR C677T (C677T) Binding (association) of associated with migraine
10) Confidence 0.31 Published 2004 Journal BMC Med Section Body Doc Link PMC375543 Disease Relevance 1.26 Pain Relevance 0.72
MTHFR genotypes associated with migraine clinical variables
MTHFR Binding (associated) of associated with migraine
11) Confidence 0.31 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 1.26 Pain Relevance 0.70
As such, further investigations utilising larger populations to clarify the genotype-phenotype interactions of the migraine susceptibility gene MTHFR are warranted.


MTHFR Binding (interactions) of associated with migraine
12) Confidence 0.30 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2919563 Disease Relevance 0.76 Pain Relevance 0.53
To our knowledge, there is no literature report on the association between vitamin B12 deficiency and MTHFR gene mutations as a possible cause of peripheral blood hemolysis.
MTHFR gene Neg (no) Binding (association) of in B12 associated with hemolysis
13) Confidence 0.29 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2626597 Disease Relevance 0.88 Pain Relevance 0
CT: Computed tomography; IBD: Inflammatory bowel disease; LMWH: Low molecular weight heparin; MTHFR: Methyleneterahydrofolate reductase; PLA: Platelet-leukocyte aggregates; TE: Thrombo-embolic; UC: Ulcerative colitis.


MTHFR Binding (aggregates) of in leukocyte associated with inflammatory bowel disease, inflammation and embolism
14) Confidence 0.27 Published 2008 Journal Thromb J Section Body Doc Link PMC2330027 Disease Relevance 1.74 Pain Relevance 0.08
We hypothesized that mutations associated with arterial vasospasm (stromelysin-1 5A/6A, eNOS T-786C) and C677T-A1298C methylene tetrahydrofolate reductase (MTHFR) interacted with cigarette-cannabis smoking, reducing vasodilatory nitric oxide (NO), promoting arterial spasm-thrombosis.
MTHFR (C677T) Binding (associated) of associated with cannabis, nicotine addiction, increased venous pressure under development and thrombosis
15) Confidence 0.16 Published 2006 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 17000887 Disease Relevance 1.14 Pain Relevance 0.09
For instance, the C677T MTHFR variant has been associated with fetal viability [60,61].
C677T MTHFR (C677T) Binding (associated) of
16) Confidence 0.08 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872313 Disease Relevance 0.06 Pain Relevance 0

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