INT138843

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 22
Disease Relevance 33.06
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (CC2D1A) microtubule organizing center (CC2D1A) cytoplasm (CC2D1A)
signal transducer activity (CC2D1A) signal transduction (CC2D1A) nucleolus (CC2D1A)
CC2D1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 52 97.12 Very High Very High Very High
Paracetamol 14 96.72 Very High Very High Very High
Inflammation 28 95.88 Very High Very High Very High
Dopamine 77 87.56 High High
Inflammatory response 85 73.68 Quite High
ischemia 35 45.28 Quite Low
cytokine 12 33.72 Quite Low
withdrawal 12 30.24 Quite Low
agonist 21 5.00 Very Low Very Low Very Low
Morphine 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 3229 100.00 Very High Very High Very High
Critical Illness 76 100.00 Very High Very High Very High
Sepsis 248 99.90 Very High Very High Very High
Cardiovascular Disease 30 99.60 Very High Very High Very High
Burns 311 98.00 Very High Very High Very High
Renal Disease 513 97.96 Very High Very High Very High
Chronic Renal Failure 191 97.92 Very High Very High Very High
INFLAMMATION 143 95.88 Very High Very High Very High
Oliguria 31 95.80 Very High Very High Very High
Acute Renal Failure 38 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Medications associated with AKI, at least in part due to toxic tubular injury, include aminoglycoside antibiotics, intravascular contrast media, amphotericin B, chemotherapeutic agents such as ifosfamide and cisplatin, acyclovir, and acetaminophen, while other medications have been implicated less commonly.
AKI Binding (associated) of associated with paracetamol and injury
1) Confidence 0.33 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.80 Pain Relevance 0.13
Several other drugs have also been associated with AKI, but the incidence of AKI with other drugs is less common.
AKI Binding (associated) of associated with injury
2) Confidence 0.33 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.08 Pain Relevance 0.16
Several candidate polymorphisms have not been shown to be associated with AKI, while other polymorphisms have been found to be associated with AKI.
AKI Binding (associated) of associated with injury
3) Confidence 0.28 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.49 Pain Relevance 0.19
Several candidate polymorphisms have not been shown to be associated with AKI, while other polymorphisms have been found to be associated with AKI.
AKI Binding (associated) of associated with injury
4) Confidence 0.28 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.59 Pain Relevance 0.19
the incidence of AKI is decreasing: true or falsegenetic factors may play a role in the susceptibility to AKI: true or falsehypoxic/ischemic AKI is a rare cause of AKI in children: true or falsenonsteroidal anti-inflammatory therapy is a risk factor for AKI in newborns: true or falseDiagnosis and etiology of AKI in children
AKI Binding (susceptibility) of associated with inflammation and injury
5) Confidence 0.25 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.20 Pain Relevance 0.05
As described above, the definition of AKI in adults and pediatric patients has been quite variable.
AKI Binding (definition) of associated with injury
6) Confidence 0.22 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.44 Pain Relevance 0
neonates, infants, children and adolescents who have recovered from AKI do not need long-term follow up: true or falseAKI that occurs before nephrogenesis is complete may lead to later CKD: true or false



falseAKI Binding (occurs) of associated with chronic renal failure and injury
7) Confidence 0.22 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.45 Pain Relevance 0.04
Only the cardiovascular dysfunction (maximum SOFA) and AKI were associated with mortality.
AKI Binding (associated) of associated with cardiovascular disease and injury
8) Confidence 0.07 Published 2008 Journal Crit Care Section Body Doc Link PMC2592761 Disease Relevance 1.45 Pain Relevance 0
There is robust experimental evidence that AKI is often associated with altered intrarenal microcirculation and oxygenation.
AKI Binding (associated) of associated with injury
9) Confidence 0.07 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 17002677 Disease Relevance 1.52 Pain Relevance 0.08
We found that severe sepsis was associated with AKI, even if not all episodes of severe sepsis caused renal dysfunction.
AKI Binding (associated) of associated with renal disease, injury and sepsis
10) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592761 Disease Relevance 2.79 Pain Relevance 0.10
However, our understanding of AKI is continuously evolving, including an appreciation of the changes in drug pharmacokinetics and pharmacodynamics that occur with AKI.
AKI Binding (occur) of associated with injury
11) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.89 Pain Relevance 0
Median time to reaching respective RIFLE class was 10 days in our AKI group, which is the same as that reported by Lopes and colleagues [20].
AKI Binding (group) of associated with injury
12) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592761 Disease Relevance 0.70 Pain Relevance 0
We found age, TBSA%, and FTB% to be predisposing factors for AKI but were unable to show the corresponding relation for severity of AKI, most probably because of a lack of power.
AKI Neg (unable) Binding (severity) of associated with injury
13) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592761 Disease Relevance 2.01 Pain Relevance 0
This finding indicates that at least some of the time-associated episodes of sepsis and renal dysfunction may also be just time-related rather than the result of cause and effect – a possibility that is usually not discussed in studies of burned patients where AKI is considered to be strongly associated with sepsis [10,12,15,17,19].


AKI Binding (associated) of associated with injury, renal disease and sepsis
14) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592761 Disease Relevance 2.18 Pain Relevance 0
Although this increased incidence may in part be due to critically ill patients representing a larger proportion of patients that are admitted into hospitals and the increased recognition of AKI, this finding is of great concern because AKI has been associated with high rates of in-hospital mortality [3-5].
AKI Binding (recognition) of associated with critical illness and injury
15) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.69 Pain Relevance 0
That study characterized the pharmacokinetics of monomethylaminoantipyrine (MMAAP), which is the pharmacologically active form of dipyrine (metamizol), and its metabolites in critically ill patients with AKI.
AKI Binding (characterized) of associated with critical illness and injury
16) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.66 Pain Relevance 0
Risk factors associated with AKI were investigated through a univariate and multivariate analysis.
AKI Binding (associated) of associated with injury
17) Confidence 0.04 Published 2010 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC3021827 Disease Relevance 0.84 Pain Relevance 0
More research, using adequate design and endpoints, is therefore needed before larger protein loads can be recommended in AKI patients on CRRT.
AKI Binding (recommended) of associated with injury
18) Confidence 0.03 Published 2008 Journal Crit Care Section Body Doc Link PMC2575562 Disease Relevance 0.25 Pain Relevance 0.04
Nephrotoxic drugs account for about 16% of all AKIs most commonly associated with AKI in older children and adolescents.
AKI Binding (associated) of associated with injury
19) Confidence 0.03 Published 2008 Journal Pediatr. Nephrol. Section Abstract Doc Link 18228043 Disease Relevance 1.48 Pain Relevance 0.19
Independent risk factors associated with AKI were abdominal trauma (OR = 3.66, 95% CI = 1.16–11.53, P = 0.027) and use of furosemide (OR = 4.10, 95% CI = 1.18–14.23, P = 0.026).
AKI Binding (associated) of associated with injury
20) Confidence 0.02 Published 2010 Journal Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine Section Body Doc Link PMC3021827 Disease Relevance 2.27 Pain Relevance 0.08

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