INT138844

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 30
Disease Relevance 41.36
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

DNA binding (CC2D1A) microtubule organizing center (CC2D1A) cytoplasm (CC2D1A)
signal transducer activity (CC2D1A) signal transduction (CC2D1A) nucleolus (CC2D1A)
Anatomy Link Frequency
liver 2
blood 1
plasma 1
lung 1
kidney 1
CC2D1A (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 48 99.98 Very High Very High Very High
methotrexate 24 97.88 Very High Very High Very High
cINOD 72 97.32 Very High Very High Very High
aspirin 20 95.64 Very High Very High Very High
Pain scale 12 85.92 High High
vincristine 12 85.44 High High
Inflammation 34 77.92 Quite High
Dopamine 88 77.60 Quite High
Bile 12 77.40 Quite High
Versed 13 60.32 Quite High
Disease Link Frequency Relevance Heat
Injury 3982 100.00 Very High Very High Very High
Hypoxia 263 100.00 Very High Very High Very High
Cv Unclassified Under Development 56 99.98 Very High Very High Very High
Necrosis 198 99.88 Very High Very High Very High
Asphyxia 17 99.72 Very High Very High Very High
Sepsis 167 99.60 Very High Very High Very High
Hemolytic Uremic Syndrome 72 99.44 Very High Very High Very High
Rhabdomyolysis 53 99.40 Very High Very High Very High
Autoimmune Disease 12 99.04 Very High Very High Very High
Increased Venous Pressure Under Development 56 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar epidemiologic studies have not been performed in pediatric patients, but hypoxia/ischemia- and nephrotoxin-induced AKI have been shown to be important causes of AKI in neonates, children and adolescents [1–10].
Positive_regulation (induced) of AKI associated with hypoxia, ischemia and injury
1) Confidence 0.41 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.91 Pain Relevance 0.05
AKI was defined as a creatinine increase of greater than 50%.
Positive_regulation (increase) of AKI
2) Confidence 0.32 Published 2009 Journal Pharmacoepidemiol Drug Saf Section Body Doc Link 19585463 Disease Relevance 0.17 Pain Relevance 0
Cortical necrosis as a cause of AKI is much more common in young children, particularly in neonates.
Positive_regulation (cause) of AKI associated with necrosis and injury
3) Confidence 0.32 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.36 Pain Relevance 0.05
The pathophysiology of hypoxia/ischemia-induced AKI is not well understood, but significant progress in elucidating the cellular, biochemical and molecular events has been made over the past several years.
Positive_regulation (induced) of AKI associated with hypoxia, ischemia and injury
4) Confidence 0.30 Published 2008 Journal Pediatr Nephrol Section Abstract Doc Link PMC2756346 Disease Relevance 1.61 Pain Relevance 0.09
Neonates with severe asphyxia had a higher incidence of AKI, while neonates with moderate asphyxia developed AKI less often [3, 7, 8].
Positive_regulation (incidence) of AKI associated with asphyxia and injury
5) Confidence 0.30 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.82 Pain Relevance 0.19
alterations in blood flow are not thought to play a role in hypoxic/ischemic AKI: true or falsereactive oxygen molecules generated by activated PMNs may play a role in hypoxic/ischemic ATN: true or falseATP depletion is an early response to hypoxic/ischemic AKI: true or falsehypoxic/ischemic AKI is always reversible and has no long-term consequences: true or falseManagement of AKI in children
Positive_regulation (response) of AKI in blood associated with necrosis, hypoxia and injury
6) Confidence 0.30 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.25 Pain Relevance 0.07
While an important cause of AKI in children, HUS will not be further discussed here, as a review of HUS has recently been published [58].


Positive_regulation (cause) of AKI associated with injury and hemolytic uremic syndrome
7) Confidence 0.27 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 2.10 Pain Relevance 0
In a large study of adult patients, the incidence of AKI was 209 per million population, and the most common cause of AKI was pre-renal in 21% of patients and acute tubular necrosis in 45% of patients [11].
Positive_regulation (cause) of AKI associated with necrosis and injury
8) Confidence 0.27 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.81 Pain Relevance 0.04
Prolonged pre-renal injury can result in intrinsic AKI due to hypoxic/ischemic acute tubular necrosis (ATN).
Positive_regulation (result) of AKI associated with necrosis, hypoxia and injury
9) Confidence 0.27 Published 2008 Journal Pediatr Nephrol Section Body Doc Link PMC2756346 Disease Relevance 1.91 Pain Relevance 0.07
The data presented in Table 3 suggest that in the rat model of uranylnitrate induced AKI there is an induction of CYP3A1 [25]; therefore, it would be expected that serum concentrations of drugs metabolized by this pathway, such as clarithromycin and telithromycin, would be decreased.
Positive_regulation (induced) of AKI associated with injury
10) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.75 Pain Relevance 0
AKI induced by nephrotoxins often manifests with a different clinical picture than AKI induced by hypoxia, sepsis, or autoimmune diseases.
Positive_regulation (induced) of AKI associated with autoimmune disease, hypoxia, injury and sepsis
11) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.63 Pain Relevance 0
Specifically, during glycerol-induced AKI in rats, there was a significant increase in CYP3A4 activity in the intestine despite a significant decrease in CYP3A4 activity in the liver.
Positive_regulation (induced) of AKI in liver associated with injury
12) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.03 Pain Relevance 0
Induction of AKI in ischemia-reperfusion rat models demonstrates decreased OAT1 and OAT3 mRNA as well as protein expression [34-36].
Positive_regulation (Induction) of AKI associated with ischemia and injury
13) Confidence 0.09 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.50 Pain Relevance 0.25
However, at present, it is remains unclear whether hypoxia per se or, rather, re-oxygenation (possibly through reactive oxygen species) causes AKI.
Spec (whether) Positive_regulation (causes) of AKI associated with hypoxia and injury
14) Confidence 0.08 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 17002677 Disease Relevance 1.38 Pain Relevance 0.06
We found that AKI was preceded by lung dysfunction in almost all of the cases, as has previously been claimed by Sheridan and colleagues [14].
Positive_regulation (preceded) of AKI in lung associated with injury
15) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2592761 Disease Relevance 1.45 Pain Relevance 0
Mortality increased with increasing AKI class.
Positive_regulation (increasing) of AKI associated with injury
16) Confidence 0.08 Published 2008 Journal Crit Care Section Body Doc Link PMC2592761 Disease Relevance 1.40 Pain Relevance 0
Although the role played by OATs in nonrenal drug clearance has not been characterized, decreased OAT1 and OAT3 activity as a result of AKI could decrease the renal secretion of drugs such as methotrexate, nonsteroidal anti-inflammatory drugs, and acetylsalicylic acid [16].
Positive_regulation (result) of AKI associated with aspirin, inflammation, injury, cinod and methotrexate
17) Confidence 0.07 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.73 Pain Relevance 0.30
These observations indicate that AKI may result in a systemic suppression of P-gp function.
Positive_regulation (result) of AKI associated with injury
18) Confidence 0.07 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 0.24 Pain Relevance 0.11
AKI induced by nephrotoxins often manifests with a different clinical picture than AKI induced by hypoxia, sepsis, or autoimmune diseases.
Positive_regulation (induced) of AKI associated with autoimmune disease, hypoxia, injury and sepsis
19) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.54 Pain Relevance 0
Even drugs that are primarily hepatically eliminated may accumulate during AKI.
Positive_regulation (accumulate) of AKI associated with injury
20) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2646335 Disease Relevance 1.36 Pain Relevance 0.09

General Comments

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