INT13885

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.11
Pain Relevance 5.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adrb2) plasma membrane (Adrb2) nucleus (Adrb2)
cytoplasm (Adrb2) signal transducer activity (Adrb2)
Anatomy Link Frequency
neurons 2
sympathetic 1
locus coeruleus 1
hippocampus 1
Adrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 35 99.68 Very High Very High Very High
bradykinin 4 99.24 Very High Very High Very High
noradrenaline 17 99.12 Very High Very High Very High
Hyperalgesia 5 98.80 Very High Very High Very High
Locus ceruleus 5 98.24 Very High Very High Very High
medulla 4 96.20 Very High Very High Very High
Hippocampus 8 93.24 High High
antagonist 14 92.88 High High
Pyramidal cell 3 92.76 High High
Catecholamine 3 91.80 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 98.80 Very High Very High Very High
Pressure Volume 2 Under Development 4 89.52 High High
Interstitial Cystitis 4 84.04 Quite High
Nociception 3 79.64 Quite High
INFLAMMATION 2 60.72 Quite High
Anxiety Disorder 1 34.64 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Immune System Diseases 1 5.00 Very Low Very Low Very Low
Hypersensitivity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronically elevated levels of epinephrine, occurring after vagotomy, desensitize peripheral beta2-adrenergic receptors and lead to enhancement of bradykinin hyperalgesia.
Positive_regulation (lead) of beta2-adrenergic associated with hyperalgesia and bradykinin
1) Confidence 0.49 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12603283 Disease Relevance 0.68 Pain Relevance 0.85
These results indicate that low doses of clonidine preferentially activate alpha 2-adrenergic autoreceptors on the noradrenaline neurons resulting in a reduction of the tonic inhibitory effect of endogenous noradrenaline on 5-HT neurotransmission, while higher doses of clonidine would decrease 5-HT neurotransmission through the direct activation of alpha 2-adrenergic heteroreceptors on 5-HT terminals.
Positive_regulation (activate) of 2-adrenergic in neurons associated with noradrenaline and clonidine
2) Confidence 0.41 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8097564 Disease Relevance 0 Pain Relevance 1.02
These results indicate that low doses of clonidine preferentially activate alpha 2-adrenergic autoreceptors on the noradrenaline neurons resulting in a reduction of the tonic inhibitory effect of endogenous noradrenaline on 5-HT neurotransmission, while higher doses of clonidine would decrease 5-HT neurotransmission through the direct activation of alpha 2-adrenergic heteroreceptors on 5-HT terminals.
Positive_regulation (activation) of 2-adrenergic in neurons associated with noradrenaline and clonidine
3) Confidence 0.41 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8097564 Disease Relevance 0 Pain Relevance 0.90
The activation of alpha 2-adrenergic heteroreceptors was studied by comparing the effectiveness of the electrical stimulation of the ascending 5-HT pathway in suppressing the firing activity of CA3 dorsal hippocampus pyramidal neurons prior to, and following, the intravenous administration of noradrenergic agents.
Positive_regulation (activation) of 2-adrenergic in hippocampus associated with pyramidal cell and hippocampus
4) Confidence 0.41 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8097564 Disease Relevance 0 Pain Relevance 0.30
Furthermore, the decrease in the effectiveness of stimulation of the locus coeruleus, obtained by increasing the frequency from 1 to 5 Hz, a phenomenon due to an increased activation of terminal alpha 2-adrenergic autoreceptors by endogenous NE, remained unaltered after long-term treatment with tandospirone.
Positive_regulation (activation) of 2-adrenergic in locus coeruleus associated with locus ceruleus
5) Confidence 0.34 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1681447 Disease Relevance 0 Pain Relevance 0.42
RESULTS: The frequency of the Arg/Arg genotype of the ADRB2 gene and the TT genotype of the IL-4 gene were significantly higher in patients with interstitial cystitis than in controls.
Positive_regulation (frequency) of ADRB2 gene
6) Confidence 0.16 Published 2002 Journal J. Urol. Section Body Doc Link 12442007 Disease Relevance 0.08 Pain Relevance 0
The increased beta-adrenoceptor densities on PBMCs in NT after clonidine, returned to baseline values after 2 h.
Positive_regulation (increased) of beta-adrenoceptor associated with clonidine
7) Confidence 0.13 Published 1994 Journal Blood Press. Section Abstract Doc Link 8069405 Disease Relevance 0.17 Pain Relevance 0.74
After clonidine at 30 and 60 min, there was an increase in beta-adrenoceptor density associated with a low affinity in NT.
Positive_regulation (increase) of beta-adrenoceptor associated with clonidine
8) Confidence 0.08 Published 1994 Journal Blood Press. Section Abstract Doc Link 8069405 Disease Relevance 0.17 Pain Relevance 0.68
These data suggest that 1) intravenous Clo only inhibits a subpopulation of RVLM sympathetic premotoneurons, possibly the C1 adrenergic cells, 2) this effect of Clo is due to activation of alpha 2-adrenergic receptors rather than nonadrenergic imidazoline binding sites, and 3) these alpha 2-receptors are located on or close to the Clo-sensitive cells and may be continuously activated by endogenously released catecholamines.
Positive_regulation (activation) of 2-adrenergic in sympathetic associated with catecholamine
9) Confidence 0.04 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7902016 Disease Relevance 0 Pain Relevance 0.21

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