INT138863

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.64
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (ABCC4) plasma membrane (ABCC4) transmembrane transport (ABCC4)
biological_process (ABCC4)
Anatomy Link Frequency
proximal 4
ABCC4 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 22 99.84 Very High Very High Very High
cINOD 12 98.82 Very High Very High Very High
Potency 2 90.40 High High
Inflammation 2 82.72 Quite High
diclofenac 2 55.60 Quite High
Disease Link Frequency Relevance Heat
Disease 2 83.08 Quite High
INFLAMMATION 6 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we studied the effect of various NSAIDs on MTX transport in membrane vesicles isolated from cells overexpressing the proximal tubular apical efflux transporters human multidrug resistance protein (MRP) 2/ABCC2 and MRP4/ABCC4.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of MRP4 in proximal associated with cinod and methotrexate
1) Confidence 0.49 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17005917 Disease Relevance 0.32 Pain Relevance 0.92
Here, we studied the effect of various NSAIDs on MTX transport in membrane vesicles isolated from cells overexpressing the proximal tubular apical efflux transporters human multidrug resistance protein (MRP) 2/ABCC2 and MRP4/ABCC4.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of ABCC4 in proximal associated with cinod and methotrexate
2) Confidence 0.49 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17005917 Disease Relevance 0.32 Pain Relevance 0.92

General Comments

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