INT138871

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.18
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Efemp2) proteinaceous extracellular matrix (Efemp2)
Anatomy Link Frequency
hepatocytes 1
Efemp2 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 3 78.00 Quite High
agonist 7 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 9 99.64 Very High Very High Very High
Hepatocellular Cancer 1 91.56 High High
Liver Disease 6 91.44 High High
Hepatotoxicity 2 88.64 High High
INFLAMMATION 1 76.56 Quite High
Targeted Disruption 10 64.00 Quite High
Epstein-barr Virus 2 60.48 Quite High
Fragile X Syndrome 21 50.00 Quite Low
Intellectual Impairment 9 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Liver injury is caused by the accumulation of alpha(1)-AT mutant Z protein in hepatocytes, which triggers downstream intracellular injury pathways.
Positive_regulation (accumulation) of mutant Z protein in hepatocytes associated with injury
1) Confidence 0.18 Published 2006 Journal Hepatology Section Abstract Doc Link 17006946 Disease Relevance 1.00 Pain Relevance 0.15
Taken together, it seems most likely that the observed decrease in I304N protein levels is due to increased turnover of the mutant protein.
Positive_regulation (increased) of mutant protein
2) Confidence 0.02 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2779495 Disease Relevance 0.11 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox