INT138872

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 30.11
Pain Relevance 4.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SPINK5) extracellular region (SPINK5) endoplasmic reticulum (SPINK5)
extracellular matrix organization (SPINK5) cytoplasm (SPINK5)
Anatomy Link Frequency
other parts 2
enterochromaffin cells 2
hepatocyte 1
pancreas 1
PMN 1
SPINK5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 31 99.98 Very High Very High Very High
Somatostatin 484 99.96 Very High Very High Very High
positron emission tomography 70 98.54 Very High Very High Very High
Dopamine 20 96.88 Very High Very High Very High
ischemia 14 93.20 High High
abdominal pain 65 91.32 High High
imagery 290 90.48 High High
Pain 13 83.04 Quite High
agonist 66 82.48 Quite High
Bile 19 81.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 800 100.00 Very High Very High Very High
Neuroendocrine Cancer 224 100.00 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 14 100.00 Very High Very High Very High
Hepatitis C Virus Infection 10 100.00 Very High Very High Very High
Hepatitis 5 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 99.98 Very High Very High Very High
Targeted Disruption 3 99.88 Very High Very High Very High
Syndrome 209 99.24 Very High Very High Very High
Gastrinoma 133 99.16 Very High Very High Very High
Carcinoid 348 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies of KC depletion in transgenic mice expressing the hepatocyte-specific hepatitis C virus (HCV) nonstructural protein NS5A suggest that hepatocytes can be the primary cellular site of both TLR4 upregulation and its pathologic consequences in HCV infection [70].


Gene_expression (expressing) of NS in hepatocyte associated with targeted disruption, hepatitis c virus infection, infection and hepatitis
1) Confidence 0.58 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.24 Pain Relevance 0.43
Most of these tumors are nonfunctional, with rectal NETs having a better prognosis than NETs in other parts of the colon.


Gene_expression (prognosis) of NETs in other parts associated with cancer
2) Confidence 0.40 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.51 Pain Relevance 0.31
This aids detection of NETs, which often demonstrate early enhancement with washout during the portal venous phase because of their hypervascular nature.
Gene_expression (detection) of NETs associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.40 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 0.35 Pain Relevance 0.15
Most of these tumors are nonfunctional, with rectal NETs having a better prognosis than NETs in other parts of the colon.


Gene_expression (prognosis) of NETs in other parts associated with cancer
4) Confidence 0.40 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.50 Pain Relevance 0.31
Pancreatic NETs account for approximately 30% of pancreatic tumors in patients younger than 20 years.
Gene_expression (account) of NETs associated with pancreatic cancer
5) Confidence 0.40 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.92 Pain Relevance 0.22
Duodenal NETs arise from gastrin cells and tend to produce Zollinger-Ellison syndrome [22].
Gene_expression (produce) of NETs associated with syndrome
6) Confidence 0.40 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.68 Pain Relevance 0.35
Unlike duodenal NETs, jejunal and ileal NETs arise from the serotonin-producing enterochromaffin cells and can cause carcinoid syndrome.
Gene_expression (arise) of NETs in enterochromaffin cells associated with carcinoid, syndrome and serotonin
7) Confidence 0.40 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.53 Pain Relevance 0.33
Unlike duodenal NETs, jejunal and ileal NETs arise from the serotonin-producing enterochromaffin cells and can cause carcinoid syndrome.
Gene_expression (arise) of NETs in enterochromaffin cells associated with carcinoid, syndrome and serotonin
8) Confidence 0.40 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.59 Pain Relevance 0.34
A second mass located in the uncinate process (arrowhead) adjacent to the portal vein was missed on initial reading. c, d FDG-PET axial images demonstrate two metabolically active foci in the pancreas, confirmed to be nonfunctional NETs at surgery

Pulmonary NETs

Gene_expression (confirmed) of NETs in pancreas associated with positron emission tomography
9) Confidence 0.40 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.69 Pain Relevance 0.08
Duodenal NETs arise from gastrin cells and tend to produce Zollinger-Ellison syndrome [22].
Gene_expression (arise) of NETs associated with syndrome
10) Confidence 0.40 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.65 Pain Relevance 0.34
While appendiceal NETs in adults are generally incidentally detected, 78–97% of appendiceal NETs in children are associated with appendicitis (Fig. 8) [18–20].
Gene_expression (detected) of NETs associated with appendicitis
11) Confidence 0.36 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 1.26 Pain Relevance 0.17
Somatostatin receptors have been extensively mapped in different pancreatic tumours by means of autoradiography, reverse-transcription polymerase chain reaction, in situ hybridization and immunohistochemistry; SSTRs 1, 2, 3 and 5 are usually expressed in pancreatic NETS.
Gene_expression (expressed) of NETS associated with pancreatic cancer and somatostatin
12) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.75 Pain Relevance 0.30
GEP NETs express somatostatin receptors (SSTRs), which are bound by somatostatin (SST) or its synthetic analogues, although the subtypes and number of SSTRs expressed is very variable.
Gene_expression (express) of NETs associated with somatostatin
13) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2845555 Disease Relevance 0.72 Pain Relevance 0.29
However, 90% of GEP NETs do not produce biologically active hormones (non functioning tumours) and therefore the diagnosis is often made too late, in presence of symptoms due to the mass effect and/or the presence of metastases, mainly hepatic metastases [1].
Neg (not) Gene_expression (produce) of NETs associated with cancer and metastasis
14) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 2.81 Pain Relevance 0
In a study examining 81 functioning and non-functioning GEP NETs the large parte of the tumours expressed SSTRs 1, 2, 3 and 5, while SSTR 4 was detected only in a small minority [10].
Gene_expression (expressed) of NETs associated with cancer
15) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 1.03 Pain Relevance 0.24
However, it is recommended to search thoroughly for MEN-1, MEN-2 and NF1 in all patients presented with NETs by obtaining family history, clinical examination, appropriate biochemical and radiological investigations and genetic testing [13].
Gene_expression (presented) of NETs associated with neuroendocrine cancer
16) Confidence 0.18 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC2204028 Disease Relevance 2.48 Pain Relevance 0.07
However, it should be noted that most laboratories, including our own, use chromogranin A monoclonal antibody to stain for NETs, therefore NETs expressing chromogranin B may be non-reactive with this antibody, as was the case with our specimen.
Gene_expression (expressing) of NETs
17) Confidence 0.10 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2542373 Disease Relevance 1.27 Pain Relevance 0.03
However, it should be noted that most laboratories, including our own, use chromogranin A monoclonal antibody to stain for NETs, therefore NETs expressing chromogranin B may be non-reactive with this antibody, as was the case with our specimen.
Gene_expression (expressing) of NETs
18) Confidence 0.09 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2542373 Disease Relevance 1.27 Pain Relevance 0.03
However, the term "classical carcinoid" is used synonymously with the term serotonin-producing GEP-NETs [10].
Gene_expression (producing) of NETs associated with carcinoid, neuroendocrine cancer and serotonin
19) Confidence 0.07 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2828985 Disease Relevance 1.47 Pain Relevance 0.14
A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas.
Gene_expression (expressing) of NETs associated with neuroendocrine cancer, syndrome, cancer and gastrinoma
20) Confidence 0.04 Published 2006 Journal World J. Gastroenterol. Section Abstract Doc Link 17006979 Disease Relevance 2.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox