INT138878

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.81
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Cldn5) plasma membrane (Cldn5)
Anatomy Link Frequency
brain 2
Cldn5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
IPN 23 95.04 Very High Very High Very High
Hyperalgesia 3 87.88 High High
Inflammation 12 87.20 High High
Multiple sclerosis 3 68.36 Quite High
Pain 11 25.00 Low Low
Disease Link Frequency Relevance Heat
Inflammatory Pain 23 95.04 Very High Very High Very High
Adhesions 3 92.24 High High
Hyperalgesia 3 87.88 High High
INFLAMMATION 3 87.20 High High
Demyelinating Disease 3 68.36 Quite High
Stroke 3 67.04 Quite High
Disease 3 65.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of the TJ proteins, which control the paracellular pathway, demonstrated decreased claudin-5 expression at 24 h, and an increase at 48 and 72 h post-injection.
Negative_regulation (decreased) of Gene_expression (expression) of claudin-5
1) Confidence 0.37 Published 2006 Journal Brain Res. Section Abstract Doc Link 17007822 Disease Relevance 0.96 Pain Relevance 0.66
The increased claudin-5 expression was not limited to the junction.
Neg (not) Negative_regulation (limited) of Gene_expression (expression) of claudin-5
2) Confidence 0.31 Published 2006 Journal Brain Res. Section Abstract Doc Link 17007822 Disease Relevance 0.75 Pain Relevance 0.49
Analysis of the TJ proteins, which control the paracellular pathway, demonstrated decreased claudin-5 expression at 24 h, and an increase at 48 and 72 h post-injection.
Negative_regulation (decreased) of Gene_expression (expression) of claudin-5
3) Confidence 0.27 Published 2006 Journal Brain Res. Section Abstract Doc Link 17007822 Disease Relevance 0.96 Pain Relevance 0.66
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Negative_regulation (inhibition) of Gene_expression (expression) of claudin-5 in brain
4) Confidence 0.18 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14

General Comments

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