INT138889

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 18.53
Pain Relevance 8.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a2)
Anatomy Link Frequency
spinal cord 4
ascending limbs 2
spinal 1
dentate gyrus 1
neurons 1
Slc12a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 13 99.68 Very High Very High Very High
Spinal cord 233 99.18 Very High Very High Very High
Neuropathic pain 163 98.56 Very High Very High Very High
Inflammation 84 98.48 Very High Very High Very High
Acute pain 1 98.12 Very High Very High Very High
nociceptor 49 97.92 Very High Very High Very High
bDMF 40 97.76 Very High Very High Very High
Hyperalgesia 167 97.40 Very High Very High Very High
Pain 58 97.28 Very High Very High Very High
Hippocampus 44 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Spinal Cord Injury 583 100.00 Very High Very High Very High
Neurological Disease 9 99.52 Very High Very High Very High
Nociception 132 99.24 Very High Very High Very High
Hyperalgesia 391 98.96 Very High Very High Very High
Injury 111 98.60 Very High Very High Very High
Neuropathic Pain 259 98.56 Very High Very High Very High
Chronic Renal Failure 496 98.52 Very High Very High Very High
INFLAMMATION 276 98.48 Very High Very High Very High
Pain 65 98.12 Very High Very High Very High
Epilepsy 92 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation suggests that the enhanced Cl- accumulation is not the consequence of transcriptional upregulation of NKCC1 or the downregulation of KCC2 transcription.
Positive_regulation (upregulation) of NKCC1
1) Confidence 0.65 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.40 Pain Relevance 0.20
After 3 hours, the p-NKCC1 signal was increased by 54% (± 3.3%; p ?
Positive_regulation (increased) of p-NKCC1
2) Confidence 0.57 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.34 Pain Relevance 0.17
Abnormal presynaptic excitation of sensory terminals has been proposed to occur via upregulation of NKCC1 in small diameter afferents after an inflammatory peripheral insult [31].
Positive_regulation (upregulation) of NKCC1 associated with inflammation
3) Confidence 0.52 Published 2007 Journal Mol Pain Section Body Doc Link PMC2093929 Disease Relevance 0.23 Pain Relevance 0.36
We, therefore, investigated expression changes of KCC2 and NKCC1 in the spinal dorsal horn of the rat after the intraplantar injection of formalin as an acute nociceptive stimulus.
Spec (investigated) Positive_regulation (changes) of NKCC1 in spinal associated with nociception and spinal dorsal horn
4) Confidence 0.49 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 17007947 Disease Relevance 0.65 Pain Relevance 0.70
Genetic ablation of the Na+-K+-2Cl- cotransporter NKCC1 was associated with reduced Cl- accumulation in DRG neurons and caused a reduced thermal nociceptive response [13] as well as attenuation of A?
Positive_regulation (caused) of NKCC1 in neurons associated with nociception
5) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.90 Pain Relevance 0.77
To test for the specificity of primary antibodies, preadsorption controls were performed for the NKCC1 (N-16) and the KCC2 (R-14) polyclonal antibodies using a 5-fold excess of blocking peptides (0.05 ?
Positive_regulation (performed) of NKCC1
6) Confidence 0.47 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.07 Pain Relevance 0.11
Moreover, the injured spinal cord tissues exhibit a significant transient upregulation of NKCC1 protein and a concurrent downregulation of KCC2 protein.
Positive_regulation (upregulation) of NKCC1 in spinal cord associated with spinal cord injury and spinal cord
7) Confidence 0.44 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20536931 Disease Relevance 0.85 Pain Relevance 0.70
As shown in Figure 3A, NKCC1 protein level was low in sham control animals and tended to increase on days 2–14 post-SCI, but did not reach statistical significance.
Positive_regulation (increase) of NKCC1 associated with spinal cord injury
8) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.73 Pain Relevance 0.43
NKCC1 was elevated on day 7 post-SCI and increased by ~60% on day 14 post-SCI (p < 0.05).
Positive_regulation (elevated) of NKCC1 associated with spinal cord injury
9) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.11 Pain Relevance 0.36
Immunoblotting showed a significant transient up-regulation of NKCC1 protein in epicenter of the rat spinal cord on day 14 post-SCI, which was accompanied by a concurrent down-regulation of KCC2 protein.
Positive_regulation (regulation) of NKCC1 in spinal cord associated with spinal cord injury and spinal cord
10) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.31 Pain Relevance 0.69
Therefore, elevation of NKCC1 and down-regulation of KCC2 in lesion epicenter may reflect the cellular repair responses following SCI.
Positive_regulation (elevation) of NKCC1 associated with spinal cord injury
11) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.03 Pain Relevance 0.50
Immunoblotting showed a significant transient up-regulation of NKCC1 protein in the lesion epicenter of the rat spinal cord on day 14 post-SCI.
Positive_regulation (regulation) of NKCC1 in spinal cord associated with spinal cord injury and spinal cord
12) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.24 Pain Relevance 1.17
The anti-hyperalgesic effect of NKCC1 inhibition suggests that normal or elevated NKCC1 function and loss of KCC2 function play a role in the development and maintenance of SCI-induced neuropathic pain.



Positive_regulation (elevated) of NKCC1 associated with hyperalgesia, spinal cord injury and neuropathic pain
13) Confidence 0.39 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2561007 Disease Relevance 1.42 Pain Relevance 0.71
Moreover, transient increase in NKCC1 protein and down-regulation of KCC2 expression were detected in the spinal cord following SCI.
Positive_regulation (increase) of NKCC1 in spinal cord associated with spinal cord injury and spinal cord
14) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.50 Pain Relevance 0.87
NKCC1 was elevated on day 7 post-SCI and increased by ~60% on day 14 post-SCI (p < 0.05).
Positive_regulation (increased) of NKCC1 associated with spinal cord injury
15) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.18 Pain Relevance 0.39
In addition, the activation of corresponding ion channels such as NKCC1 plays an important role in increasing the concentration of Na+ ions in ischemic cerebral tissue [33-35].
Positive_regulation (activation) of NKCC1
16) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3004923 Disease Relevance 0.52 Pain Relevance 0.03
Amygdalar kindling of adult rats increased NKCC1 in the piriform cortex [231] and dentate gyrus [232]; decreased KCC1 and Clc2 in the dentate gyrus and Clc2 in the CA1 pyramidal region of the hippocampus, but had no effect on KCC2 [232].
Positive_regulation (increased) of NKCC1 in dentate gyrus associated with hippocampus
17) Confidence 0.24 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.67 Pain Relevance 0.27
Palma et al. independently concluded that cell membranes from human epileptic tissue, when injected into Xenopus oocytes, elicited depolarizing GABAAergic currents, which was linked to upregulation of NKCC1 and downregulation of KCC2 [237].
Positive_regulation (upregulation) of NKCC1 in oocytes associated with epilepsy
18) Confidence 0.24 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.97 Pain Relevance 0.19
Using human brain tissue from patients deceased from non-neurological disorders, similar developmental increase in KCC2 over NKCC1 was identified in the cortex postnatally, suggesting that a similar gradient of GABAAergic responses may occur [65].
Positive_regulation (increase) of NKCC1 in cortex associated with neurological disease
19) Confidence 0.24 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.10 Pain Relevance 0.03
Members of the serine-threonine kinase WNK (With No lysine (K)), SPAK (Serine Proline Alanine lysine (K) rich), and oxidative stress responsive (OSR) kinase families have drawn much focus in related research, showing that they are important, cooperatively or independently, in the activation of NKCC1, NKCC2, NCCs and de-activation of KCCs [77, 86, 134] [259] [57].
Positive_regulation (activation) of NKCC1 associated with stress
20) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.10 Pain Relevance 0.19

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox