INT138891

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2008
Negated 1
Speculated 3
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 4.83
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a2)
Anatomy Link Frequency
proximal 4
spinal 2
spinal cord 2
Slc12a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 138 100.00 Very High Very High Very High
spinal dorsal horn 3 99.68 Very High Very High Very High
Hyperalgesia 66 99.32 Very High Very High Very High
Spinal cord 62 99.16 Very High Very High Very High
Inflammation 57 98.80 Very High Very High Very High
Acute pain 1 98.56 Very High Very High Very High
bradykinin 15 97.64 Very High Very High Very High
Lasting pain 1 94.20 High High
Pain 19 94.04 High High
antagonist 19 92.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 201 100.00 Very High Very High Very High
Chronic Renal Failure 372 99.84 Very High Very High Very High
Spinal Cord Injury 144 99.56 Very High Very High Very High
Hyperalgesia 122 99.32 Very High Very High Very High
Pain 19 98.56 Very High Very High Very High
Nociception 51 96.20 Very High Very High Very High
Neuropathic Pain 68 91.32 High High
Hypertrophy 33 75.48 Quite High
Ganglion Cysts 6 50.00 Quite Low
Hypersensitivity 4 47.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the changes in NKCC1 and KCC2 expression are consistent with increased Cl- accumulation, the time course of the expression changes lags behind the rise in [Cl-]i.
Regulation (changes) of Gene_expression (expression) of NKCC1
1) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.15 Pain Relevance 0.08
These data demonstrate that NKCC1 and KCC2 expression levels remain unchanged over 2 hr of treatment with inflammatory mediators.
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of NKCC1 associated with inflammatory mediators
2) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.17 Pain Relevance 0.08
We, therefore, investigated expression changes of KCC2 and NKCC1 in the spinal dorsal horn of the rat after the intraplantar injection of formalin as an acute nociceptive stimulus.
Spec (investigated) Regulation (changes) of Spec (investigated) Gene_expression (expression) of NKCC1 in spinal associated with nociception and spinal dorsal horn
3) Confidence 0.26 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 17007947 Disease Relevance 0.65 Pain Relevance 0.70
We studied the effects of inflammatory mediators on the intracellular Cl- concentration as well as on the expression of NKCC1 and KCC2.
Regulation (effects) of Gene_expression (expression) of NKCC1 associated with inflammatory mediators
4) Confidence 0.25 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.53 Pain Relevance 0.48
We investigated changes in NKCC1 protein levels in the epicenter of spinal cord tissue harvested at 2, 7, and 14 days post-SCI.
Spec (investigated) Regulation (changes) of Gene_expression (levels) of NKCC1 in spinal cord associated with spinal cord injury and spinal cord
5) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.09 Pain Relevance 0.42
Taken together, expression of NKCC1 and KCC2 proteins was differentially altered following SCI.
Regulation (altered) of Gene_expression (expression) of NKCC1 associated with spinal cord injury
6) Confidence 0.23 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2561007 Disease Relevance 1.48 Pain Relevance 0.74
In the present study, we aimed to examine the effects of AngII AT1 receptor blockade on the expression of major renal sodium transporters (NHE3, BSC-1, and TSC) and vasopressin-regulated aquaporin-2 (AQP2) in rats with an early stage of CRF induced by 5/6 nephrectomy.
Spec (examine) Regulation (effects) of Spec (examine) Gene_expression (expression) of BSC-1 associated with chronic renal failure
7) Confidence 0.09 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.30 Pain Relevance 0.14
Moreover, candesartan treatment potentiated the upregulation of BSC-1 protein expression in CRF rats, and this is also compatible with the view that BSC-1 expression is regulated by the prolonged increase in the NaCl load delivered to the TAL due to both hyperfiltration and altered expression in the proximal tubule sodium transporters in remnant kidneys.
Regulation (regulated) of Gene_expression (expression) of BSC-1 in proximal associated with chronic renal failure
8) Confidence 0.09 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.23 Pain Relevance 0
Moreover, candesartan treatment potentiated the upregulation of BSC-1 protein expression in CRF rats, and this is also compatible with the view that BSC-1 expression is regulated by the prolonged increase in the NaCl load delivered to the TAL due to both hyperfiltration and altered expression in the proximal tubule sodium transporters in remnant kidneys.
Regulation (upregulation) of Gene_expression (expression) of BSC-1 in proximal associated with chronic renal failure
9) Confidence 0.09 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.22 Pain Relevance 0

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