INT138910

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 95 89.84 High High
chemokine 6 79.24 Quite High
cINOD 4 75.00 Quite High
aspirin 2 75.00 Quite High
cytokine 34 63.76 Quite High
Inflammatory response 7 53.84 Quite High
agonist 10 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 105 89.84 High High
Inflammatory Bowel Disease 47 88.72 High High
Colitis 31 82.80 Quite High
Disease 20 82.16 Quite High
Cancer 28 60.64 Quite High
Repression 5 23.00 Low Low
Metastasis 3 6.44 Low Low
Toxicity 13 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that sulindac selectively inhibited IFNgamma-inducible gene expression without inhibiting STAT1 activation.
Negative_regulation (inhibiting) of Positive_regulation (activation) of STAT1
1) Confidence 0.57 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.25 Pain Relevance 0.22
We have initiated a detailed investigation into the molecular mechanism of suppression of STAT1 activation by PEO that will be described elsewhere in the future.
Negative_regulation (suppression) of Positive_regulation (activation) of STAT1
2) Confidence 0.37 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.33 Pain Relevance 0.03
interacts with the protein inhibitor of the activated transcription factor, STAT-1 (PIAS1).
Negative_regulation (inhibitor) of Positive_regulation (activated) of STAT-1
3) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.23 Pain Relevance 0.14

General Comments

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