INT138913

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.22
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl9)
Anatomy Link Frequency
lung 4
macrophages 2
leukocytes 2
tonsil 2
T cells 2
Cxcl9 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 150 100.00 Very High Very High Very High
cINOD 2 99.72 Very High Very High Very High
aspirin 2 99.54 Very High Very High Very High
Inflammation 106 97.64 Very High Very High Very High
Inflammatory stimuli 1 88.76 High High
Crohn's disease 52 88.72 High High
interstitial cystitis 82 80.60 Quite High
cytokine 78 75.04 Quite High
Inflammatory mediators 3 52.56 Quite High
Pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 108 99.62 Very High Very High Very High
Colitis 142 98.76 Very High Very High Very High
Pharyngitis 1 98.12 Very High Very High Very High
Mycobacterial Infection 293 98.08 Very High Very High Very High
Cellulitis 1 97.88 Very High Very High Very High
Infection 288 96.88 Very High Very High Very High
Cancer 14 95.60 Very High Very High Very High
Disease 123 93.44 High High
Cystitis 140 88.56 High High
Bacterial Infection 4 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac, a nonsteroidal anti-inflammatory drug, selectively inhibits interferon-gamma-induced expression of the chemokine CXCL9 gene in mouse macrophages.
Negative_regulation (inhibits) of Gene_expression (expression) of CXCL9 in macrophages associated with chemokine, inflammation and cinod
1) Confidence 0.58 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 17010317 Disease Relevance 0.39 Pain Relevance 0.28
Furthermore, tonsil fluid collected from patients with Streptococcus pyogenes pharyngitis contains CXCL9 concentrations exceeding those required to kill S. pyogenes in vitro, and the inhibition of CXCL9 expression reduces antimicrobial activity against this organism at the surface of inflamed pharyngeal cells [38].
Negative_regulation (inhibition) of Gene_expression (expression) of CXCL9 in tonsil associated with pharyngitis and cellulitis
2) Confidence 0.49 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.84 Pain Relevance 0.22
Anti-CXCL10 Ab treatment significantly decreased the expression of CXCL9 and CXCR3 mRNAs by iliac lymph node leukocytes and reduced the production of CXCL9, CXCL10, CXCL11, and CXCR3 mRNAs by urinary bladder leukocytes.
Negative_regulation (reduced) of Gene_expression (production) of CXCL9 in leukocytes
3) Confidence 0.42 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.53 Pain Relevance 0.15
However, increases in serum CXCL10 (and CXCL9) concentrations were significantly reduced following CXCL10 blockade in mice that received CYP.
Negative_regulation (reduced) of Gene_expression (blockade) of CXCL9
4) Confidence 0.41 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.02 Pain Relevance 0.24
Sulindac, but not aspirin or sodium salicylate, inhibited IFNgamma-induced expression of the CXC ligand 9 (CXCL9) mRNA, a chemokine for activated T cells, whereas the interferon-induced expression of CXCL10 or IFN regulatory factor-1 was not affected by sulindac.
Negative_regulation (inhibited) of Gene_expression (expression) of ligand 9 in T cells associated with chemokine and aspirin
5) Confidence 0.37 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.32 Pain Relevance 0.25
The numbers of MLN and LP DCs subsets expressing CXCL9 and CXCL11 after the onset of colitis were significantly increased during live Mycobacteria-enhanced colitis than in the other groups with the exception of MLN CXCL10+ myeloid DCs that were elevated following live bacterial challenge.
Negative_regulation (numbers) of Gene_expression (expressing) of CXCL9 associated with colitis
6) Confidence 0.32 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.62 Pain Relevance 0.06
In the present study, we show that CXCL9 and CXCL11 are predominantly produced by DCs in the MLN as well as in PP and to a lesser degree in the intestinal LP.
Negative_regulation (degree) of Gene_expression (produced) of CXCL9
7) Confidence 0.31 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.48 Pain Relevance 0.08
This hypothesis is tested by depleting neutrophils between D10–15 and we show that this results in decreased expression of CXCL9 mRNA expression and reduced accumulation of Th1 cells in the M.tuberculosis-infected lung on D21.
Negative_regulation (decreased) of Gene_expression (expression) of CXCL9 mRNA in lung associated with mycobacterial infection and infection
8) Confidence 0.26 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 1.04 Pain Relevance 0.04
This hypothesis is tested by depleting neutrophils between D10–15 and we show that this results in decreased expression of CXCL9 mRNA expression and reduced accumulation of Th1 cells in the M.tuberculosis-infected lung on D21.
Negative_regulation (decreased) of Gene_expression (expression) of CXCL9 mRNA in lung associated with mycobacterial infection and infection
9) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020951 Disease Relevance 0.99 Pain Relevance 0.04

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