INT138914

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.02
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 20 90.72 High High
chemokine 2 88.36 High High
aspirin 1 84.12 Quite High
Central nervous system 6 75.28 Quite High
cINOD 2 75.00 Quite High
Nerve growth factor 2 57.20 Quite High
Bioavailability 1 54.56 Quite High
cytokine 8 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 8 95.04 Very High Very High Very High
INFLAMMATION 24 90.72 High High
Alzheimer's Dementia 3 81.92 Quite High
Disease 11 81.20 Quite High
Cancer 100 69.76 Quite High
Stress 3 67.40 Quite High
Necrosis 2 51.68 Quite High
Apoptosis 27 5.00 Very Low Very Low Very Low
Metastasis 19 5.00 Very Low Very Low Very Low
Dna Damage 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For calculation of the IFN/STAT1 pathway expression score (ES) we used the equation , where Gi?
Regulation (calculation) of Positive_regulation (/) of STAT1
1) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
Surprisingly, sulindac had no inhibitory effect on IFNgamma-induced STAT1 activation; however, constitutive nuclear factor kappaB activity was suppressed by the drug.
Neg (no) Regulation (effect) of Positive_regulation (activation) of STAT1
2) Confidence 0.44 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.28 Pain Relevance 0.23
Apigenin and luteolin's mechanism of action appears to be targeted at regulating STAT1 activation.
Regulation (regulating) of Positive_regulation (activation) of STAT1
3) Confidence 0.24 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.74 Pain Relevance 0.25

General Comments

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