INT138915

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2006
Last Reported 2010
Negated 6
Speculated 5
Reported most in Body
Documents 144
Total Number 150
Disease Relevance 69.53
Pain Relevance 5.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
lung 27
macrophage 2
liver 2
nucleus 2
spleen 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 638 100.00 Very High Very High Very High
chemokine 76 99.76 Very High Very High Very High
addiction 217 99.26 Very High Very High Very High
fibrosis 505 98.98 Very High Very High Very High
rheumatoid arthritis 66 98.60 Very High Very High Very High
Paracetamol 122 98.08 Very High Very High Very High
Multiple sclerosis 66 97.68 Very High Very High Very High
cytokine 692 95.68 Very High Very High Very High
Central nervous system 167 95.44 Very High Very High Very High
aspirin 7 93.04 High High
Disease Link Frequency Relevance Heat
Cancer 10734 100.00 Very High Very High Very High
Apoptosis 2451 100.00 Very High Very High Very High
INFLAMMATION 677 100.00 Very High Very High Very High
Targeted Disruption 637 100.00 Very High Very High Very High
Renal Cancer 108 99.84 Very High Very High Very High
Metastasis 2184 99.32 Very High Very High Very High
Lymphatic System Cancer 153 99.28 Very High Very High Very High
Head & Neck Cancer 108 99.16 Very High Very High Very High
Dna Damage 1080 99.00 Very High Very High Very High
Inflammatory Bowel Disease 224 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we reported that constitutive overexpression of the STAT1 pathway is associated with suppression of caspases 8, 9, and 3 and therefore with suppression of the apoptotic response in radiation and interferon resistant tumor cells [44].
Gene_expression (overexpression) of STAT1 associated with cancer and apoptosis
1) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.93 Pain Relevance 0
Thus, an increase in the frequency of the STAT1H cell lines and an increase in the mean level of STAT1 expression scores occurs during the progression from P1 to P3 (Figure 3A-C).
Gene_expression (expression) of STAT1
2) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.15 Pain Relevance 0
Expression of the IFN/STAT1 pathway was measured relative to B16F1 monoculture as described above.


Gene_expression (Expression) of STAT1
3) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.15 Pain Relevance 0
These results demonstrate that tumor clones with increased expression of the IFN/STAT1 pathway possess an aggressive phenotype with an enhanced ability to colonize the lungs.
Gene_expression (expression) of STAT1 in lungs associated with cancer
4) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.28 Pain Relevance 0
We were then able to identify relationships between expression levels of the IFN/STAT1 pathway, resistance of tumor clones to cytotoxic agents, and the ability of tumor clones to colonize lungs.
Gene_expression (expression) of STAT1 in lungs associated with cancer
5) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.38 Pain Relevance 0
However, the biological significance of overexpression of the IFN/STAT1 pathway remained unclear.
Gene_expression (overexpression) of STAT1
6) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.82 Pain Relevance 0
Here we report that clones of B16F1 tumors grown in the lungs of syngeneic C57BL/6 mice demonstrate variable transcriptional levels of IFN/STAT1 pathway expression.
Gene_expression (expression) of STAT1 in lungs associated with cancer
7) Confidence 0.77 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688034 Disease Relevance 0.87 Pain Relevance 0
Overexpression of the IFN/STAT1 pathway is also associated with poor prognosis in different types of cancer and may have predictive value in breast cancer patients selected for the adjuvant chemotherapy [24], [25].
Gene_expression (Overexpression) of STAT1 associated with cancer and breast cancer
8) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.86 Pain Relevance 0
Fryknas et al [22] showed that overexpression of the IFN/STAT1 pathway in myeloma cell lines is associated with cross-resistance to IR and Dox.
Gene_expression (overexpression) of STAT1
9) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.38 Pain Relevance 0.03
The observation that constitutive overexpression of the IFN/STAT1 pathway confers aggressive and therapy resistant tumor clones leaves several unanswered questions which need to be explored including the mechanisms by which activation of the IFN/STAT1 pathway switches the pathway from “cytotoxic” to “pro-survival” and the mechanisms that underlie this switch.
Gene_expression (overexpression) of STAT1 associated with cancer
10) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.79 Pain Relevance 0.03
Consistent with our observations are recent reports indicating that constitutive overexpression of STAT1 and STAT1-dependent genes is associated with protection of tumor cells from genotoxic stress following treatment with fludarabine [19], doxorubicin (Dox) [20], cisplatin [21], and the combination of IR and Dox [22], [23].
Gene_expression (overexpression) of STAT1 associated with dna damage and cancer
11) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.81 Pain Relevance 0
To quantify IFN/STAT1 pathway expression levels in multiple samples using QRT-PCR, we used a five gene marker set (STAT1, IFIT1, IFIT3, IFITM1, and MX1) (see [18]).
Gene_expression (expression) of STAT1
12) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
In this regard, we asked whether overexpression of the IFN/STAT1 pathway provides such a selective advantage to tumor cells, thereby leading to improved lung colonization.
Spec (whether) Gene_expression (overexpression) of STAT1 in lung associated with cancer
13) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 1.02 Pain Relevance 0.07
The two cell lines from the P2H panel with the highest STAT1 expression score, P2M3C (expression score?
Gene_expression (expression) of STAT1
14) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.09 Pain Relevance 0
We previously demonstrated an association between an IR-resistant phenotype and overexpression of IFN/STAT1 pathway in head and neck cancer cell lines [17].
Gene_expression (overexpression) of STAT1 in neck associated with head & neck cancer
15) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.77 Pain Relevance 0
The individual lung colonies, which are believed to be the progeny of a single lung colonizing tumor cell [52], were used to establish cell lines in which we examined levels of expression of the IFN/STAT1 pathway.
Gene_expression (expression) of STAT1 in lung associated with cancer
16) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.60 Pain Relevance 0.03
We used a similar approach but focused on expression of the IFN/STAT1 pathway (Figure 4A).
Gene_expression (expression) of STAT1
17) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.22 Pain Relevance 0
We followed the model of experiments from Fidler and colleagues [26] with the addition of screening established cell lines for expression of IFN/STAT1 pathway genes.
Gene_expression (expression) of STAT1
18) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.34 Pain Relevance 0.04
These results indicate that B16F1 lung colony forming efficiency is significantly associated with expression levels of the IFN/STAT1 pathway.


Gene_expression (expression) of STAT1 in lung
19) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.18 Pain Relevance 0
Most recently Hui et al [24] found overexpression of STAT1 in renal cell carcinoma relative to normal kidney cells and were subsequently able to radiosensitize tumor cells in vitro by suppressing STAT1 using siRNA or fludarabine.
Gene_expression (overexpression) of STAT1 in kidney associated with cancer and renal cancer
20) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.72 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox