INT138916

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 9.88
Pain Relevance 3.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl9)
Anatomy Link Frequency
T cells 3
lymph node 2
coronary artery 1
lymphocytes 1
GCT 1
Cxcl9 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 153 99.60 Very High Very High Very High
cytokine 104 99.20 Very High Very High Very High
aspirin 2 99.00 Very High Very High Very High
Inflammation 192 98.80 Very High Very High Very High
rheumatoid arthritis 204 98.64 Very High Very High Very High
Osteoarthritis 100 97.80 Very High Very High Very High
fibrosis 39 95.60 Very High Very High Very High
interstitial cystitis 205 91.36 High High
cINOD 4 75.00 Quite High
Lasting pain 5 65.08 Quite High
Disease Link Frequency Relevance Heat
Respiratory Syncytial Virus 102 99.46 Very High Very High Very High
Coronary Artery Disease 24 99.44 Very High Very High Very High
INFLAMMATION 191 98.80 Very High Very High Very High
Rheumatoid Arthritis 204 98.64 Very High Very High Very High
Osteoarthritis 100 97.80 Very High Very High Very High
Cystitis 350 96.90 Very High Very High Very High
Atherosclerosis 6 96.36 Very High Very High Very High
Fibrosis 37 95.60 Very High Very High Very High
Interstitial Cystitis 205 91.36 High High
Disease 108 86.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac, but not aspirin or sodium salicylate, inhibited IFNgamma-induced expression of the CXC ligand 9 (CXCL9) mRNA, a chemokine for activated T cells, whereas the interferon-induced expression of CXCL10 or IFN regulatory factor-1 was not affected by sulindac.
Transcription (expression) of CXCL9 in T cells associated with chemokine and aspirin
1) Confidence 0.68 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.32 Pain Relevance 0.25
Sulindac, but not aspirin or sodium salicylate, inhibited IFNgamma-induced expression of the CXC ligand 9 (CXCL9) mRNA, a chemokine for activated T cells, whereas the interferon-induced expression of CXCL10 or IFN regulatory factor-1 was not affected by sulindac.
Transcription (expression) of ligand 9 in T cells associated with chemokine and aspirin
2) Confidence 0.59 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.32 Pain Relevance 0.25
We demonstrate that CXCR3 as well as CXCL9, CXCL10 and CXCL11 mRNA were significantly expressed by urinary bladder lymphocytes, while CXCR3 and CXCL9 transcripts were significantly expressed by iliac lymph node leukocytes following CYP treatment.
Transcription (expressed) of CXCL9 in lymphocytes
3) Confidence 0.51 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.54 Pain Relevance 0.34
We demonstrate that CXCR3 as well as CXCL9, CXCL10 and CXCL11 mRNA were significantly expressed by urinary bladder lymphocytes, while CXCR3 and CXCL9 transcripts were significantly expressed by iliac lymph node leukocytes following CYP treatment.
Transcription (expressed) of CXCL9 in lymph node
4) Confidence 0.51 Published 2008 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC2583981 Disease Relevance 0.55 Pain Relevance 0.35
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Transcription (transcripts) of CXCL9 in T cell
5) Confidence 0.51 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.19 Pain Relevance 0.40
CYP-induced cystitis in mice led to substantial increases in the expression of CXCL10, CXCL11, and CXCR3 mRNA by urinary bladder leukocytes as well as modest increases in the expression of CXCL9 and CXCR3 transcripts by iliac lymph node lymphocytes than compared to normal, untreated mice (Figure 3A).
Transcription (expression) of CXCL9 in lymph node associated with cystitis
6) Confidence 0.51 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.62 Pain Relevance 0.08
In the present study, we found that RSV reduces V2O5-induced mRNA levels of type I IFNs, CXCL9 and CXCL10.
Transcription (levels) of CXCL9 associated with respiratory syncytial virus
7) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.27 Pain Relevance 0.31
CXCL9 mRNA was detected after 29 cycles with the primers 5'-GGA GTG CAA GGA ACC CCA GTA-3' and 5'-CTT TTG GCT GAC CTG TTT CTC-3', and CXCL10 mRNA was amplified using 26 cycles with the primers 5'-ATT TGC TGC CTT ATC TTT CTG-3' and 5'-GAC ATC TCT TCT CAC CCT TCT-3', at annealing temperatures of 52°C and 55°C, respectively.
Transcription (detected) of CXCL9 in GCT
8) Confidence 0.43 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0 Pain Relevance 0
Concomitantly, significantly increased mRNA levels of CXCL9 and CXCL10 were also detected in RA synovial tissue.
Transcription (levels) of CXCL9 associated with rheumatoid arthritis
9) Confidence 0.43 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 1.28 Pain Relevance 0.72
Urinary bladder histology as well as mucosal (iliac lymph node and urinary bladder) and peripheral (spleen) leukocyte expression of CXCR3, CXCL9, CXCL10, and CXCL11 mRNA transcripts as well as CD4+ T cell, mast cell, and NK/NKT cell numbers were compared among naïve and CYP-treated mice given control or anti-CXCL10 Abs.
Transcription (transcripts) of CXCL9 in mast cell
10) Confidence 0.17 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.19 Pain Relevance 0.40
Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group.
Transcription (expression) of CXCL9 associated with coronary artery disease
11) Confidence 0.13 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.95 Pain Relevance 0.30
We evaluated mRNA expression and protein production of CCL2, CXCL8, CXCL9, CXCL10, IFN-gamma and IL-10 in vitro as well as the expression of the CCR2 and CXCR3 receptors in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls in the presence or absence of oxidized LDL (oxLDL).
Transcription (expression) of CXCL9 in coronary artery associated with coronary artery disease
12) Confidence 0.13 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.69 Pain Relevance 0.26
Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group.
Transcription (expression) of CXCL9 associated with coronary artery disease
13) Confidence 0.13 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.95 Pain Relevance 0.30

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