INT138917

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 63
Total Number 67
Disease Relevance 36.76
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
lung 24
macrophage 4
neck 3
nucleus 2
mesenchymal cells 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 118 100.00 Very High Very High Very High
fibrosis 101 95.72 Very High Very High Very High
aspirin 4 93.04 High High
Inflammation 82 89.48 High High
cytokine 279 89.36 High High
metalloproteinase 4 87.08 High High
chemokine 19 84.72 Quite High
cINOD 5 75.00 Quite High
ketamine 59 8.12 Low Low
palliative 60 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 5749 100.00 Very High Very High Very High
Apoptosis 1226 100.00 Very High Very High Very High
Lymphatic System Cancer 81 99.92 Very High Very High Very High
Renal Cancer 59 99.84 Very High Very High Very High
Inflammatory Bowel Disease 76 99.60 Very High Very High Very High
Metastasis 1185 99.32 Very High Very High Very High
Head & Neck Cancer 59 99.16 Very High Very High Very High
Dna Damage 590 99.00 Very High Very High Very High
Breast Cancer 374 97.56 Very High Very High Very High
Stress 132 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, stable transfection of STAT1 in the radiosensitive SCC61 cell line led to the formation of an IR- and IFN-resistant phenotype, thus confirming that constitutive overexpression of STAT1 conferred resistance to genotoxic stress.
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1 associated with dna damage
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.73 Pain Relevance 0
Fryknas et al [22] showed that overexpression of the IFN/STAT1 pathway in myeloma cell lines is associated with cross-resistance to IR and Dox.
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1
2) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.38 Pain Relevance 0.03
Overexpression of the IFN/STAT1 pathway is also associated with poor prognosis in different types of cancer and may have predictive value in breast cancer patients selected for the adjuvant chemotherapy [24], [25].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of STAT1 associated with cancer and breast cancer
3) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.86 Pain Relevance 0
The observation that constitutive overexpression of the IFN/STAT1 pathway confers aggressive and therapy resistant tumor clones leaves several unanswered questions which need to be explored including the mechanisms by which activation of the IFN/STAT1 pathway switches the pathway from “cytotoxic” to “pro-survival” and the mechanisms that underlie this switch.
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1 associated with cancer
4) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.79 Pain Relevance 0.03
In this regard, we asked whether overexpression of the IFN/STAT1 pathway provides such a selective advantage to tumor cells, thereby leading to improved lung colonization.
Spec (whether) Positive_regulation (overexpression) of Spec (whether) Gene_expression (overexpression) of STAT1 in lung associated with cancer
5) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 1.02 Pain Relevance 0.07
Most recently Hui et al [24] found overexpression of STAT1 in renal cell carcinoma relative to normal kidney cells and were subsequently able to radiosensitize tumor cells in vitro by suppressing STAT1 using siRNA or fludarabine.
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1 in kidney associated with cancer and renal cancer
6) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.72 Pain Relevance 0.04
Thus, an increase in the frequency of the STAT1H cell lines and an increase in the mean level of STAT1 expression scores occurs during the progression from P1 to P3 (Figure 3A-C).
Positive_regulation (increase) of Gene_expression (expression) of STAT1
7) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.15 Pain Relevance 0
Recently, we reported that constitutive overexpression of the STAT1 pathway is associated with suppression of caspases 8, 9, and 3 and therefore with suppression of the apoptotic response in radiation and interferon resistant tumor cells [44].
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1 associated with cancer and apoptosis
8) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.93 Pain Relevance 0
Consistent with our observations are recent reports indicating that constitutive overexpression of STAT1 and STAT1-dependent genes is associated with protection of tumor cells from genotoxic stress following treatment with fludarabine [19], doxorubicin (Dox) [20], cisplatin [21], and the combination of IR and Dox [22], [23].
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1 associated with dna damage and cancer
9) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.81 Pain Relevance 0
An increase in STAT1 expression and activation in human UC was observed by Schreiber et al., [27].
Positive_regulation (increase) of Gene_expression (expression) of STAT1 associated with inflammatory bowel disease
10) Confidence 0.60 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.33 Pain Relevance 0.08
In the current report we show that the ability to colonize the lungs is associated with constitutive overexpression of the IFN/STAT1 pathway (STAT1H genotype).
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1 in lungs
11) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.17 Pain Relevance 0
We demonstrate the pre-existence of clones in the B16F1 tumor cell population that overexpress the IFN/STAT1 pathway.
Positive_regulation (overexpress) of Gene_expression (overexpress) of STAT1 associated with cancer
12) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.67 Pain Relevance 0.04
Furthermore, stable transfection of STAT1 in the radiosensitive SCC61 cell line led to the formation of an IR- and IFN-resistant phenotype, thus confirming that constitutive overexpression of STAT1 conferred resistance to genotoxic stress.
Positive_regulation (transfection) of Gene_expression (transfection) of STAT1 associated with dna damage
13) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.76 Pain Relevance 0
The two cell lines from the P2H panel with the highest STAT1 expression score, P2M3C (expression score?
Positive_regulation (highest) of Gene_expression (expression) of STAT1
14) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.09 Pain Relevance 0
Therefore, consistent with our previous observations [17], [18], tumors overexpressing the IFN/STAT1 pathway are resistant to both IR and IFN?.


Positive_regulation (overexpressing) of Gene_expression (overexpressing) of STAT1 associated with cancer
15) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.79 Pain Relevance 0
Tumor cells that constitutively overexpress the IFN/STAT1 pathway (STAT1H genotype) are selected by the lung microenvironment.
Positive_regulation (overexpress) of Gene_expression (overexpress) of STAT1H in lung associated with cancer
16) Confidence 0.50 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688034 Disease Relevance 0.88 Pain Relevance 0
led to constitutive overexpression of the IFN/STAT1 pathway and development of resistance to IR [18].
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1
17) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.42 Pain Relevance 0
Here we report that tumor cells that constitutively overexpress the IFN/STAT1 pathway, and are thus resistant to the cytotoxic effects of this pathway, are preferentially selected for colonization by the lung microenvironment.
Positive_regulation (overexpress) of Gene_expression (overexpress) of STAT1 in lung associated with cancer
18) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.64 Pain Relevance 0
Based on these findings, we hypothesized that in vivo selection of developing tumor clones would be associated with the ability of tumor cells to overexpress the IFN/STAT1 pathway while resisting IFN?
Positive_regulation (overexpress) of Gene_expression (overexpress) of STAT1 associated with cancer
19) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.79 Pain Relevance 0
To test the hypothesis that overexpression of the IFN/STAT1 pathway in B16F1 cells correlates with IFN?
Positive_regulation (overexpression) of Gene_expression (overexpression) of STAT1
20) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.19 Pain Relevance 0

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