INT138919

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Context Info
Confidence 0.60
First Reported 2006
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 4.58
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
macrophage 4
lungs 4
heart 4
liver 1
spleen 1
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 2 93.04 High High
Inflammation 2 91.44 High High
chemokine 4 84.72 Quite High
cINOD 2 75.00 Quite High
cytokine 20 5.00 Very Low Very Low Very Low
addiction 10 5.00 Very Low Very Low Very Low
palliative 5 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 482 99.84 Very High Very High Very High
Apoptosis 103 99.40 Very High Very High Very High
Targeted Disruption 195 97.36 Very High Very High Very High
Dislocations 5 95.36 Very High Very High Very High
Dna Damage 50 93.64 High High
INFLAMMATION 4 91.44 High High
Experimental Melanoma 5 88.24 High High
Dilated Cardiomyopathy 15 75.48 Quite High
Death 28 70.52 Quite High
Hypersensitivity 6 67.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the effect of sulindac on intracellular signaling pathways in host immune cells such as macrophages, we investigated the effect of the drug on interferon gamma (IFNgamma)-induced expression of signal transducer and activator of transcription 1 (STAT1) and other genes in mouse macrophage-like cell line RAW264.7 cells.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of STAT1 in macrophage
1) Confidence 0.60 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.35 Pain Relevance 0.25
For calculation of the IFN/STAT1 pathway expression score (ES) we used the equation , where Gi?
Regulation (calculation) of Gene_expression (expression) of STAT1
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
To test the effects of IFN/STAT1 pathway expression levels on the apoptotic response to Dox we used three STAT1H cell lines (P3m2a, P2m3c, P3m5a) and three STAT1L cell lines (P2m3, P2m6b, and P2m5b).
Regulation (effects) of Gene_expression (expression) of STAT1 associated with apoptosis
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.60 Pain Relevance 0
These data indicate that the expression level of the IFN/STAT1 pathway affects the ability of B16F1 cells to colonize the lungs following IV injection.


Regulation (affects) of Gene_expression (expression) of STAT1 in lungs
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.22 Pain Relevance 0
Here we report that clones of B16F1 tumors grown in the lungs of syngeneic C57BL/6 mice demonstrate variable transcriptional levels of IFN/STAT1 pathway expression.
Regulation (levels) of Gene_expression (expression) of STAT1 in lungs associated with cancer
5) Confidence 0.45 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688034 Disease Relevance 0.87 Pain Relevance 0
Subsequently, cell lines were designated STAT1H if their IFN/STAT1 pathway expression score was?
Regulation (score) of Gene_expression (expression) of STAT1
6) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.17 Pain Relevance 0
To determine the effect of sulindac on intracellular signaling pathways in host immune cells such as macrophages, we investigated the effect of the drug on interferon gamma (IFNgamma)-induced expression of signal transducer and activator of transcription 1 (STAT1) and other genes in mouse macrophage-like cell line RAW264.7 cells.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of signal transducer and activator of transcription 1 in macrophage
7) Confidence 0.44 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.35 Pain Relevance 0.25
Real-time PCR analysis of the mRNA of OSA1 and STAT1 failed to detect changes in the expression levels of these two genes in the heart, spleen, and liver in the transgenic line 8 (Figure 5), indicating no interferon response in these transgenic mice.
Regulation (changes) of Gene_expression (expression) of STAT1 in heart associated with targeted disruption
8) Confidence 0.43 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.67 Pain Relevance 0
Real-time PCR analysis of the mRNA of OSA1 and STAT1 failed to detect changes in the expression levels of these two genes in the heart, spleen, and liver in the transgenic line 8 (Figure 5), indicating no interferon response in these transgenic mice.
Regulation (changes) of in liver Gene_expression (expression) of STAT1 in heart associated with targeted disruption
9) Confidence 0.15 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.67 Pain Relevance 0
Real-time PCR analysis of the mRNA of OSA1 and STAT1 failed to detect changes in the expression levels of these two genes in the heart, spleen, and liver in the transgenic line 8 (Figure 5), indicating no interferon response in these transgenic mice.
Regulation (changes) of in spleen Gene_expression (expression) of STAT1 in heart associated with targeted disruption
10) Confidence 0.15 Published 2006 Journal PLoS Genet Section Body Doc Link PMC1358942 Disease Relevance 0.67 Pain Relevance 0

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