INT138920

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 5.72
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cxcl10) extracellular space (Cxcl10) extracellular region (Cxcl10)
Anatomy Link Frequency
T cells 4
retinas 2
spleen 2
Cxcl10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 11 100.00 Very High Very High Very High
chemokine 49 99.60 Very High Very High Very High
cytokine 80 99.30 Very High Very High Very High
ischemia 19 99.20 Very High Very High Very High
interstitial cystitis 82 98.32 Very High Very High Very High
aspirin 3 96.78 Very High Very High Very High
Inflammation 235 95.24 Very High Very High Very High
Inflammatory mediators 4 85.56 High High
cINOD 7 75.00 Quite High
agonist 10 67.44 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 243 100.00 Very High Very High Very High
Disease 82 100.00 Very High Very High Very High
Eye Disease 63 99.72 Very High Very High Very High
Brain Hemorrhage 3 99.20 Very High Very High Very High
Interstitial Cystitis 82 98.32 Very High Very High Very High
Cystitis 140 95.56 Very High Very High Very High
Ocular & Orbital Inflammation 1 95.24 Very High Very High Very High
Thyroid Disease 4 93.80 High High
Injury 14 91.00 High High
Cancer 157 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B-regulated expression of Tnf, Il6, Ccl2, Ccl5, Cxcl10, and Icam1 [22] were significantly reduced in Tlr4 KO versus WT retinas, suggesting that the neuroprotective effect is in part due to Tlr4-NF-?
Regulation (regulated) of Gene_expression (expression) of Cxcl10 in retinas
1) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956702 Disease Relevance 0.97 Pain Relevance 0.35
Our results show that CXCL10 blockade does not affect the percentage of CD4+ T cells in the spleen of naïve mice, but inhibition of CXCL10 in CYP-treated mice with cystitis lead to an increase in the percentage of T helper splenocytes.
Neg (not) Regulation (affect) of Gene_expression (blockade) of CXCL10 in spleen associated with cystitis
2) Confidence 0.43 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.77 Pain Relevance 0.35
Taken together, the higher expression of CXCL9 in man and CXCL10 in mouse, during clinical and experimental disease, respectively, could be explained by these promoter differences or the imperfect correlation between clinical disease and the experimental mouse model used in this study.
Regulation (explained) of Gene_expression (expression) of CXCL10 associated with disease
3) Confidence 0.43 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.15 Pain Relevance 0.53
Sulindac, but not aspirin or sodium salicylate, inhibited IFNgamma-induced expression of the CXC ligand 9 (CXCL9) mRNA, a chemokine for activated T cells, whereas the interferon-induced expression of CXCL10 or IFN regulatory factor-1 was not affected by sulindac.
Neg (not) Regulation (affected) of Gene_expression (expression) of CXCL10 in T cells associated with chemokine and aspirin
4) Confidence 0.39 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.31 Pain Relevance 0.25
Out of these 7 responding genes, concentration-dependent changes in IL6, CXCL10 and STAT1 (signal transducer and activator of transcription1) expressions have been confirmed using real time RT-PCR (Fig 4) and Western Blot analyses respectively (Fig 5).
Spec (analyses) Regulation (changes) of Gene_expression (expressions) of CXCL10
5) Confidence 0.18 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.44 Pain Relevance 0.11
A recent study found that orbital fibroblasts from TED patients may modulate the activity of T lymphocytes through the production of CXCL10 [35].
Spec (may) Regulation (modulate) of Gene_expression (production) of CXCL10 in T lymphocytes associated with eye disease
6) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2266979 Disease Relevance 1.32 Pain Relevance 0.11
, have been found to stabilize a significant number of cytokines and chemokines including CXCL-10 (IP-10), GRO proteins, and fractalkine (SCYD1), and several genes involved in regulation of inflammatory responses such as TNFAIP3, NF?
Regulation (regulation) of Gene_expression (responses) of IP-10 associated with chemokine, inflammatory response and cytokine
7) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.76 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox