INT138922

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 57
Total Number 59
Disease Relevance 28.35
Pain Relevance 7.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Anatomy Link Frequency
lung 3
T cells 3
macrophages 2
fibroblasts 2
adipose tissue 2
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 43 100.00 Very High Very High Very High
agonist 33 99.88 Very High Very High Very High
Paracetamol 23 99.40 Very High Very High Very High
fibrosis 310 97.84 Very High Very High Very High
Inflammation 696 97.56 Very High Very High Very High
cytokine 438 97.22 Very High Very High Very High
cINOD 92 97.16 Very High Very High Very High
adenocard 11 95.12 Very High Very High Very High
Inflammatory response 66 90.24 High High
ischemia 31 90.08 High High
Disease Link Frequency Relevance Heat
Apoptosis 564 100.00 Very High Very High Very High
Lymphatic System Cancer 88 99.92 Very High Very High Very High
Hepatotoxicity 9 99.70 Very High Very High Very High
Dna Damage 190 99.60 Very High Very High Very High
Disease 440 99.52 Very High Very High Very High
Breast Cancer 130 99.52 Very High Very High Very High
Cancer 2551 99.42 Very High Very High Very High
Alzheimer's Dementia 14 99.28 Very High Very High Very High
Targeted Disruption 403 99.26 Very High Very High Very High
Obesity 84 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior studies demonstrate that activation of the IFN/STAT1 pathway can be measured by PCR-based quantification of gene expression using marker ISGs [33]–[36].
Positive_regulation (activation) of STAT1
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.17 Pain Relevance 0
These results indicate that sulindac selectively inhibited IFNgamma-inducible gene expression without inhibiting STAT1 activation.
Positive_regulation (activation) of STAT1
2) Confidence 0.68 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.25 Pain Relevance 0.22
We have initiated a detailed investigation into the molecular mechanism of suppression of STAT1 activation by PEO that will be described elsewhere in the future.
Positive_regulation (activation) of STAT1
3) Confidence 0.60 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.33 Pain Relevance 0.03
In macrophages we also observed a novel dose-dependent decrease of activated STAT1 (pSTAT1) in the nucleus by PEO/PEITC (Fig 5).
Positive_regulation (activated) of STAT1 in macrophages
4) Confidence 0.60 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.28 Pain Relevance 0.04
Activation of STAT1 that is harmful in liver injury was augmented in SOCS3Tg hepatocytes.
Positive_regulation (Activation) of STAT1 in liver associated with injury
5) Confidence 0.54 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.89 Pain Relevance 0.53
In macrophages we also observed a novel dose-dependent decrease of activated STAT1 (pSTAT1) in the nucleus by PEO/PEITC (Fig 5).
Positive_regulation (activated) of pSTAT1 in macrophages
6) Confidence 0.52 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.28 Pain Relevance 0.04
Thus, an increase in the frequency of the STAT1H cell lines and an increase in the mean level of STAT1 expression scores occurs during the progression from P1 to P3 (Figure 3A-C).
Positive_regulation (increase) of STAT1
7) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.15 Pain Relevance 0
Finally, to provide mechanistic evidence of the dependence of STAT1 on the observed aggressive STAT1H genotype, we generated stable STAT1 knockdowns in the P2M5A cell line, which was the highest overexpressor of STAT1H in the P2 passage (Figure 3).
Positive_regulation (dependence) of STAT1 associated with addiction
8) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.40 Pain Relevance 0.05
The two cell lines from the P2H panel with the highest STAT1 expression score, P2M3C (expression score?
Positive_regulation (highest) of STAT1
9) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.09 Pain Relevance 0
Emerging functions of a constitutively activated IFN/STAT1 pathway suggest an association with an aggressive tumor phenotype.
Positive_regulation (activated) of STAT1 associated with cancer
10) Confidence 0.50 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688034 Disease Relevance 0.58 Pain Relevance 0
Based on these findings, we hypothesized that in vivo selection of developing tumor clones would be associated with the ability of tumor cells to overexpress the IFN/STAT1 pathway while resisting IFN?
Positive_regulation (/) of STAT1 associated with cancer
11) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.79 Pain Relevance 0
For calculation of the IFN/STAT1 pathway expression score (ES) we used the equation , where Gi?
Positive_regulation (/) of STAT1
12) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
Development of tumor clones proficient in lung colonization and resistant to genotoxic stress is mechanistically connected to STAT1
Positive_regulation (connected) of STAT1 in lung associated with dna damage and cancer
13) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.87 Pain Relevance 0
To quantify IFN/STAT1 pathway expression levels in multiple samples using QRT-PCR, we used a five gene marker set (STAT1, IFIT1, IFIT3, IFITM1, and MX1) (see [18]).
Positive_regulation (/) of STAT1
14) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0 Pain Relevance 0
The observation that constitutive overexpression of the IFN/STAT1 pathway confers aggressive and therapy resistant tumor clones leaves several unanswered questions which need to be explored including the mechanisms by which activation of the IFN/STAT1 pathway switches the pathway from “cytotoxic” to “pro-survival” and the mechanisms that underlie this switch.
Positive_regulation (activation) of STAT1 associated with cancer
15) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.84 Pain Relevance 0
IFN-mediated STAT1 transcriptional induction results in the transcription of several hundred genes designated the Interferon-Stimulated Genes (ISG; see [8], [31], [32] for reviews).
Positive_regulation (induction) of STAT1
16) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.14 Pain Relevance 0
The mean STAT1 expression score shows a progressive increase from the P1 to the P3 passage with a significant difference between the P1 and P3 panels of cell lines (Student's two-tailed t-test; p?
Positive_regulation (mean) of STAT1
17) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.07 Pain Relevance 0
To test this hypothesis, we compared two cell lines derived from second generation lung colonies (P2) in which P2M3C was derived from pooled P1 STAT1H cell lines (P2H) and P2M6B was derived from pooled P1 STAT1L cell lines (P2L) (Figure 3 and Figure S2).
Positive_regulation (pooled) of STAT1H in lung
18) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.47 Pain Relevance 0
Indeed, in an ex vivo co-culture model it was demonstrated that stromal fibroblasts can secrete IFNs, activating the IFN/STAT1 pathway in breast cancer cells, and that this pathway is associated with poor prognosis in patients with breast cancer due to the development of metastases [48].
Positive_regulation (activating) of STAT1 in fibroblasts associated with breast cancer and metastasis
19) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.67 Pain Relevance 0
These observations lead us to hypothesize that the development of tumor clones overexpressing the IFN/STAT1 pathway is associated with selection against IFNs, and perhaps other STAT1-activating ligands, secreted by the host microenvironment leading to the selection of cells resistant to the cytotoxic effects of transient STAT1 activation.
Positive_regulation (activation) of STAT1 associated with cancer
20) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.78 Pain Relevance 0

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