INT138927

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Context Info
Confidence 0.29
First Reported 2006
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.70
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng) nucleolus (Stat1)
nucleus (Stat1) enzyme binding (Stat1) DNA binding (Stat1)
Anatomy Link Frequency
macrophage 4
Ifng (Mus musculus)
Stat1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 2 93.04 High High
Inflammation 2 90.56 High High
chemokine 4 84.72 Quite High
cINOD 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 4 93.68 High High
INFLAMMATION 4 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the effect of sulindac on intracellular signaling pathways in host immune cells such as macrophages, we investigated the effect of the drug on interferon gamma (IFNgamma)-induced expression of signal transducer and activator of transcription 1 (STAT1) and other genes in mouse macrophage-like cell line RAW264.7 cells.
interferon gamma Spec (investigated) Positive_regulation (induced) of Gene_expression (expression) of STAT1 in macrophage
1) Confidence 0.29 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.35 Pain Relevance 0.25
To determine the effect of sulindac on intracellular signaling pathways in host immune cells such as macrophages, we investigated the effect of the drug on interferon gamma (IFNgamma)-induced expression of signal transducer and activator of transcription 1 (STAT1) and other genes in mouse macrophage-like cell line RAW264.7 cells.
IFNgamma Spec (investigated) Positive_regulation (induced) of Gene_expression (expression) of STAT1 in macrophage
2) Confidence 0.29 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17010317 Disease Relevance 0.35 Pain Relevance 0.25

General Comments

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