INT13893

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Context Info
Confidence 0.36
First Reported 1982
Last Reported 1994
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.78
Pain Relevance 9.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cubn) Golgi apparatus (Cubn) endoplasmic reticulum (Cubn)
protein complex (Cubn) cytoplasm (Cubn)
Anatomy Link Frequency
nucleus accumbens 1
cerebral cortex 1
caudate-putamen 1
kidney 1
Cubn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 47 100.00 Very High Very High Very High
agonist 24 100.00 Very High Very High Very High
antagonist 19 100.00 Very High Very High Very High
Morphine 26 99.98 Very High Very High Very High
dopamine receptor 10 99.44 Very High Very High Very High
withdrawal 3 98.36 Very High Very High Very High
Analgesic 3 98.24 Very High Very High Very High
opiate 19 98.08 Very High Very High Very High
analgesia 8 97.24 Very High Very High Very High
Nucleus accumbens 3 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 6 96.24 Very High Very High Very High
Hypotension 14 95.64 Very High Very High Very High
Nociception 1 90.40 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence is presented in this report to show that morphine acts presynaptically to acutely inhibit DA release, and thus, that morphine inhibition of DA receptor mediated responses is indirect, being the result of an inhibition of pre-synaptic DA release rather than a direct effect exerted on post-synaptic DA receptors themselves.
Negative_regulation (inhibition) of DA receptor associated with dopamine and morphine
1) Confidence 0.36 Published 1982 Journal Subst Alcohol Actions Misuse Section Abstract Doc Link 6764309 Disease Relevance 0 Pain Relevance 1.30
Therefore in the present study the effect of DE gamma E was examined on DA receptor agonist-induced inhibition of the electrically evoked release of previously accumulated [3H]DA from rat nucleus accumbens slices in vitro.
Spec (examined) Negative_regulation (inhibition) of DA receptor in nucleus accumbens associated with nucleus accumbens, dopamine and agonist
2) Confidence 0.26 Published 1987 Journal Brain Res. Section Abstract Doc Link 2961411 Disease Relevance 0 Pain Relevance 0.90
The mixed dopamine receptor antagonist, RS-sulpiride and the selective DA2-receptor antagonist, S-sulpiride, antagonized the cardiovascular actions of quinpirole.
Negative_regulation (antagonist) of DA2-receptor associated with antagonist and dopamine receptor
3) Confidence 0.23 Published 1985 Journal J Auton Pharmacol Section Abstract Doc Link 2869041 Disease Relevance 0.86 Pain Relevance 0.38
These selective dopamine receptor agonists and the selective DA1-receptor antagonist, SCH 23390 offer novel pharmacological probes for characterization of dopamine receptor subtypes in the kidney and other peripheral organs.
Negative_regulation (antagonist) of DA1-receptor in kidney associated with antagonist, dopamine receptor and agonist
4) Confidence 0.23 Published 1985 Journal J Auton Pharmacol Section Abstract Doc Link 2869041 Disease Relevance 0.68 Pain Relevance 0.45
We found a decrease of DA2 receptor density in the target areas of the mesolimbocortical system (ventral n. caudate-putamen, cerebral cortex except for the anterior cingulate at the most anterior level and the n. accumbens) and a decrease of opiate and benzodiazepine receptors in the cerebral cortex and in the olfactory tubercle.
Negative_regulation (decrease) of DA2 receptor in caudate-putamen associated with opiate, anterior cingulate and cerebral cortex
5) Confidence 0.21 Published 1991 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 1851615 Disease Relevance 0 Pain Relevance 0.52
Co-administration of CLG with morphine attenuated these DA receptor changes at 24 hours which is consistent with the peptide's effect on stereotyped behavior.
Negative_regulation (attenuated) of DA receptor associated with dopamine and morphine
6) Confidence 0.16 Published 1987 Journal Alcohol Drug Res Section Abstract Doc Link 2431697 Disease Relevance 0 Pain Relevance 1.36
To study the effect of DA receptor blockade on the antiopiate properties of Tyr-MIF-1, the opiate form of footshock-induced analgesia was elicited in the rat.
Negative_regulation (blockade) of DA receptor associated with dopamine, opiate and analgesia
7) Confidence 0.13 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1681456 Disease Relevance 0.09 Pain Relevance 0.63
Since DA antagonists do not act by binding opiate receptors, it is quite likely that morphine and other opiate mu receptor agonists may at least partially induce many of their acute central effects by means of an inhibition of postsynaptic DA receptor arousal.
Negative_regulation (inhibition) of DA receptor associated with dopamine, antagonist, agonist, opiate and morphine
8) Confidence 0.07 Published 1984 Journal Neuropsychobiology Section Abstract Doc Link 6090975 Disease Relevance 0 Pain Relevance 2.00
We found a decrease of DA2 receptor density in the target areas of the mesolimbocortical system (ventral n. caudate-putamen, cerebral cortex except for the anterior cingulate at the most anterior level and the n. accumbens) and a decrease of opiate and benzodiazepine receptors in the cerebral cortex and in the olfactory tubercle.
Negative_regulation (decrease) of DA2 receptor in cerebral cortex associated with opiate, anterior cingulate and cerebral cortex
9) Confidence 0.07 Published 1991 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 1851615 Disease Relevance 0 Pain Relevance 0.52
These effects are related to the blockade of the central DA receptor.
Negative_regulation (blockade) of DA receptor
10) Confidence 0.00 Published 1994 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 7834858 Disease Relevance 0 Pain Relevance 1.16

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