INT138939

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.89
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
brain 4
spinal 2
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 7 98.02 Very High Very High Very High
Somatostatin 1 95.28 Very High Very High Very High
Inflammation 14 94.72 High High
Pain 3 94.60 High High
Antinociceptive 2 83.44 Quite High
Nerve growth factor 2 82.08 Quite High
analgesia 1 75.00 Quite High
antinociception 3 64.40 Quite High
Analgesic 1 53.28 Quite High
Neuropathic pain 2 42.88 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 94.72 High High
Pain 1 94.60 High High
Nociception 4 80.44 Quite High
Neuropathic Pain 2 42.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that mRNA expression levels of alpha-calcitonin gene-related peptides, tropomyosin-related kinase-A (trkA), p75 neurotrophin receptor (p75(NTR)), and brain-derived neurotrophic factor (BDNF) elevated significantly after CFA treatment.
Positive_regulation (elevated) of Transcription (levels) of p75 in brain
1) Confidence 0.43 Published 2007 Journal J Pain Section Abstract Doc Link 17010673 Disease Relevance 0.40 Pain Relevance 0.20
Our results showed that mRNA expression levels of alpha-calcitonin gene-related peptides, tropomyosin-related kinase-A (trkA), p75 neurotrophin receptor (p75(NTR)), and brain-derived neurotrophic factor (BDNF) elevated significantly after CFA treatment.
Positive_regulation (elevated) of Transcription (levels) of p75 in brain
2) Confidence 0.43 Published 2007 Journal J Pain Section Abstract Doc Link 17010673 Disease Relevance 0.40 Pain Relevance 0.20
We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA.
Positive_regulation (increasing) of Transcription (transcript) of neurotrophin receptor in spinal associated with paracetamol and somatostatin
3) Confidence 0.12 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17088403 Disease Relevance 0.09 Pain Relevance 0.91

General Comments

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