INT138941

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
nerve 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 100.00 Very High Very High Very High
bDMF 32 95.68 Very High Very High Very High
Nucleus accumbens 8 94.08 High High
Hippocampus 17 92.44 High High
Raphe 6 89.76 High High
midbrain 1 88.80 High High
Inflammation 7 88.72 High High
Eae 23 77.44 Quite High
Neurotransmitter 13 69.76 Quite High
depression 84 68.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 88.72 High High
Depression 91 68.88 Quite High
Nociception 1 66.76 Quite High
Neuropathic Pain 1 63.68 Quite High
Depressive Disorder 1 63.12 Quite High
Targeted Disruption 27 50.00 Quite Low
Neurodegenerative Disease 7 35.64 Quite Low
Stress 10 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, there was no change in mRNA expression levels for neurotrophin-4/5, beta-nerve growth factor (beta-NGF), trkB, glial cell line-derived neurotrophin factor, and receptor protein tyrosine kinase protein.
Neg (no) Regulation (change) of Transcription (expression) of trkB in nerve associated with nerve growth factor
1) Confidence 0.47 Published 2007 Journal J Pain Section Abstract Doc Link 17010673 Disease Relevance 0.51 Pain Relevance 0.33
Biarylpropylsulfonamide AMPA receptor potentiator (LY404187) and its active isomer (LY451646) showed a dose and time-dependent modulation of BDNF and TrkB mRNA expression [180].
Regulation (modulation) of Transcription (expression) of TrkB
2) Confidence 0.23 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.25 Pain Relevance 0.62

General Comments

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