INT138954

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Context Info
Confidence 0.27
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
nerve 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 100.00 Very High Very High Very High
Inflammation 12 96.00 Very High Very High Very High
Neuropathic pain 1 70.96 Quite High
Neurotransmitter 1 62.88 Quite High
metalloproteinase 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 10 96.00 Very High Very High Very High
Neuropathic Pain 1 70.96 Quite High
Nociception 1 66.76 Quite High
Breast Cancer 1 65.68 Quite High
Acute Coronary Syndrome 49 61.12 Quite High
Genetic Predisposition To Disease 3 60.40 Quite High
Disorder Of Lipid Metabolism 5 50.36 Quite High
Nicotine Addiction 4 49.32 Quite Low
Diabetes Mellitus 3 23.20 Low Low
Hypertension 3 22.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcription of the EGFR gene is regulated by two enhancer elements.
Regulation (regulated) of Transcription (Transcription) of EGFR gene
1) Confidence 0.27 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2515827 Disease Relevance 0.29 Pain Relevance 0
In contrast, there was no change in mRNA expression levels for neurotrophin-4/5, beta-nerve growth factor (beta-NGF), trkB, glial cell line-derived neurotrophin factor, and receptor protein tyrosine kinase protein.
Neg (no) Regulation (change) of Transcription (levels) of receptor protein tyrosine kinase protein in nerve associated with nerve growth factor
2) Confidence 0.02 Published 2007 Journal J Pain Section Abstract Doc Link 17010673 Disease Relevance 0.53 Pain Relevance 0.35

General Comments

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